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XPC Gene Xeroderma pigmentosum, group C NGS Genetic Test

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XPC Gene Xeroderma pigmentosum, group C NGS Genetic Test

Short Name: XPC Gene XP-C NGS Test

Also known as: XP-C, Xeroderma Pigmentosum Group C, XPC Gene Test

XPC Gene Xeroderma pigmentosum, group C NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood, Extracted DNA, or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose Xeroderma Pigmentosum Group C by detecting mutations in the XPC gene using NGS technology, enabling early intervention and management to reduce skin cancer risk.

Test Code
5178
Price
₹20,000
Sample Type
Blood, Extracted DNA, or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with Xeroderma Pigmentosum.

Method: Venipuncture for blood

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or use of FTA card for one drop of blood.

Step 3

Report Delivery

Sample is labeled, stored at ambient room temperature, and sent to the laboratory for NGS analysis.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test implications, informed consent, and collection of clinical history.
2
During the Test:Blood sample collection via venipuncture or FTA card, followed by laboratory processing for NGS analysis.
3
After the Test:Report generation within 3-4 weeks, with delivery via online portal, email, or WhatsApp. Post-test genetic counseling recommended.

About This Test

Who Should Get This Test

To diagnose Xeroderma Pigmentosum Group C by detecting mutations in the XPC gene using NGS technology, enabling early intervention and management to reduce skin cancer risk.

How to Prepare

  • Ensure proper sample handling and labeling
  • Use sterile equipment for blood collection
  • Follow standard phlebotomy procedures

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"As a dermatologist, I recommend this test for patients with symptoms of Xeroderma Pigmentosum, such as extreme UV sensitivity or unusual skin lesions, to confirm diagnosis and guide management strategies for skin cancer prevention."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, or One drop Blood on FTA Card
Collection MethodVenipuncture for blood

Sample Stability

Blood samples stable at room temperature for up to 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of mutations in the XPC gene and other genes associated with Xeroderma Pigmentosum, aiding in the diagnosis of XP-C.
Positive: Pathogenic mutation detected in the XPC gene, confirming diagnosis of Xeroderma Pigmentosum Group C.
Negative: No pathogenic variants detected, but clinical correlation is necessary as symptoms may persist.
Variant of uncertain significance (VUS): Genetic variant identified with unknown clinical impact; further testing or family studies may be required.
Carrier status: Mutation detected in one copy of the gene, indicating carrier status for autosomal recessive inheritance.
⚠️ When to Consult a Doctor:

If symptoms such as extreme UV sensitivity, unusual skin lesions, or family history of XP persist, consult a dermatologist or geneticist for evaluation and management.

Limitations

  • ⚠Test may not detect all possible mutations or variants of uncertain significance
  • ⚠Requires genetic counseling for proper interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risks from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results, including anxiety or stress
  • ●Potential for uncertain results requiring further investigation

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Insufficient DNA quantity
  • ●Hemolyzed blood samples

Compare With Similar Tests

TestXPC Gene Xeroderma pigmentosum, group C NGS Genetic TestXPA Gene Xeroderma Pigmentosum Group A NGS TestXPB Gene Xeroderma Pigmentosum Group B NGS TestXPD Gene Xeroderma Pigmentosum Group D NGS TestXPE Gene Xeroderma Pigmentosum Group E NGS Test
ComparisonXPC Gene Xeroderma pigmentosum, group C NGS Genetic Test

Frequently Asked Questions

What is Xeroderma Pigmentosum Group C (XP-C)?
XP-C is a rare genetic disorder caused by mutations in the XPC gene, leading to extreme sensitivity to UV radiation and increased risk of skin cancer.
What are the symptoms of XP-C?
Symptoms include freckles, pigmentation changes, dry and rough skin, premature aging, and skin cancers in sun-exposed areas, often appearing in childhood.
How is XP-C diagnosed?
Diagnosis involves genetic testing, such as the NGS Genetic Test, to detect mutations in the XPC gene, along with clinical evaluation and family history assessment.
What does the NGS Genetic Test involve?
The test uses Next-Generation Sequencing to analyze the XPC gene and other XP-related genes from a blood sample or extracted DNA.
What is the cost of the XPC Gene NGS Genetic Test?
The test costs INR 20000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get results?
Results are typically delivered within 3-4 weeks via online portal, email, or WhatsApp.
What should I do if the test is positive?
A positive result confirms XP-C diagnosis; consult a dermatologist or geneticist for management strategies, including UV protection and regular skin cancer screenings.
Is genetic counseling necessary before and after the test?
Yes, genetic counseling is recommended to understand test implications, draw a family pedigree chart, and interpret results accurately.
Can this test detect other types of Xeroderma Pigmentosum?
The test primarily targets the XPC gene but may include analysis of other XP-associated genes for comprehensive diagnosis.
Is the test covered by insurance?
Coverage varies by insurance provider; it is not typically covered under government schemes like PMJAY or CGHS. Check with your insurer for details.
How accurate is the NGS Genetic Test for XP-C?
NGS technology provides high accuracy for detecting mutations, but results should be correlated with clinical findings and may require confirmation in some cases.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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