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DNA Labs India

ZIC3 Gene Heterotaxy, visceral type 1 NGS Genetic Test

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ZIC3 Gene Heterotaxy, visceral type 1 NGS Genetic Test

Short Name: ZIC3 Heterotaxy Test

Also known as: ZIC3 Gene Heterotaxy Test, Visceral Heterotaxy Type 1 Genetic Test, ZIC3 NGS Test

ZIC3 Gene Heterotaxy, visceral type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

🩺 Medically Reviewed By

Overview

The purpose of this test is to detect mutations in the ZIC3 gene that cause heterotaxy, visceral type 1, enabling accurate diagnosis, guiding treatment strategies, and facilitating genetic counseling for families.

Test Code
5760
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Ensure proper identification and consent.

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or using FTA card for one drop of blood.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store sample as instructed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session recommended to discuss test implications and draw a pedigree chart.
2
During the Test:Sample collection and analysis performed in a certified laboratory using NGS technology.
3
After the Test:Results delivered in 3 to 4 weeks. Follow-up consultation advised for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the ZIC3 gene that cause heterotaxy, visceral type 1, enabling accurate diagnosis, guiding treatment strategies, and facilitating genetic counseling for families.

How to Prepare

  • Use sterile equipment
  • Label sample correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic testing for ZIC3 mutations is crucial for diagnosing heterotaxy, guiding management, and informing family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the ZIC3 gene. Positive results confirm a diagnosis of heterotaxy, visceral type 1, while negative results may require further testing.
Positive result: Mutation detected, indicating genetic cause for heterotaxy.
Negative result: No mutation detected, but clinical correlation is needed.
Variant of uncertain significance: Requires additional family studies and clinical evaluation.
⚠️ When to Consult a Doctor:

Consult a genetic specialist or pediatrician if symptoms persist, for family planning advice, or to understand test results and management options.

Limitations

  • May not detect all genetic variants
  • Requires genetic counseling for interpretation
  • Results may not predict disease severity

Risks & Considerations

  • Minimal risk from blood draw, such as bruising or infection

Interfering Factors

  • Sample contamination
  • Degraded DNA
  • Improper sample handling

Frequently Asked Questions

What is ZIC3 Gene Heterotaxy, Visceral Type 1?
It is a genetic disorder caused by mutations in the ZIC3 gene, leading to abnormal arrangement of internal organs such as the heart, lungs, liver, and spleen.
What are the symptoms of this disorder?
Symptoms include abnormal organ placement, heart defects, lung abnormalities, liver and spleen issues, and digestive problems.
How is the test performed?
The test uses Next-Generation Sequencing (NGS) to analyze DNA from a blood sample or extracted DNA for mutations in the ZIC3 gene.
What is the cost of the test?
The cost is INR 20000.0, which includes home sample collection across India.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Who should consider this test?
Individuals with symptoms of heterotaxy, family history of the disorder, or unexplained organ abnormalities should consider this test.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What does a positive result mean?
A positive result indicates a mutation in the ZIC3 gene, confirming a genetic cause for heterotaxy, which guides treatment and management.
Can this test be used for prenatal diagnosis?
This test is typically for postnatal diagnosis; consult a genetic counselor for prenatal options.
Is genetic counseling provided?
Yes, a genetic counseling session is recommended before and after the test to discuss implications and results.
What are the limitations of the test?
The test may not detect all genetic variants, and results require clinical correlation and genetic counseling for interpretation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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Your medical data is protected under Indian law.

Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

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