Whole Exome Sequencing in India: Cost, Benefits & Booking
At a Glance
- Sample Required: Peripheral blood (2-3 ml) in EDTA tube
- Fasting Rules: No fasting required
- Turnaround Time: 4-5 weeks
- Base Cost: ₹20,000
What is Whole Exome Sequencing?
Whole Exome Sequencing (WES) is a cutting-edge genetic test designed to identify disease-causing mutations across thousands of genes. The exome, which represents the protein-coding regions of the genome (~1% of the human genome), contains around 85% of all disease-related mutations. By focusing on these coding regions, WES provides a highly efficient method to uncover the genetic basis of rare and complex disorders.
WES sequences ~20,000 protein-coding genes using Next-Generation Sequencing (NGS) technology, offering precise, comprehensive, and actionable insights for patients with unexplained medical conditions.
Clinical Indications for WES
Whole Exome Sequencing is especially beneficial for:
- Individuals with complex, unspecific genetic disorders.
- Genetically heterogeneous disorders where multiple genes could be responsible.
- Suspected genetic disorders without a specific available test.
- Cases where previous genetic testing was inconclusive.
Compared to single-gene tests, WES provides a fast, cost-effective, and comprehensive solution, reducing the need for multiple stepwise tests and improving the chances of accurate diagnosis. It is particularly effective when performed alongside parents or first-degree relatives for better interpretation.
Advantages of Whole Exome Sequencing
- High diagnostic yield (20-60% depending on the condition).
- Detects rare and complex genetic variants in a single test.
- Speeds up diagnosis and guides personalized treatment.
- Reduces unnecessary testing and healthcare costs.
WES vs. Targeted Panels vs. Whole Genome Sequencing
Understanding the differences between genomic testing options helps in selecting the most appropriate test. The table below compares key features:
| Feature | Whole Exome Sequencing (WES) | Targeted Gene Panel | Whole Genome Sequencing (WGS) |
|---|---|---|---|
| Genes Analyzed | ~20,000 protein-coding genes | 10-500 genes (disease-specific) | Entire genome (~3 billion base pairs) |
| Diagnostic Yield | 20-60% depending on phenotype | 10-30% depending on panel | 30-50% (includes non-coding regions) |
| Cost (India) | ~₹20,000 | ₹10,000-₹30,000 | ₹50,000-₹1,00,000+ |
| Turnaround Time | 4-5 weeks | 2-4 weeks | 6-8 weeks |
Where to Get Whole Exome Sequencing in India
DNA Labs India is a leading molecular diagnostics company providing Whole Exome Sequencing across 180+ cities in India, including:
- New Delhi, Mumbai, Kolkata, Chennai, Bangalore, Hyderabad, Ahmedabad
We offer home sample collection or lab-based collection, ensuring convenience, confidentiality, and safety.
How to Book Your Whole Exome Sequencing Test
- Visit www.dnalabsindia.com
- Call the city-specific helpline numbers listed below.
- Our trained sample collectors will visit your home at your convenient time slot.
City Contact Numbers:
- New Delhi: (011) 40849842
- Mumbai: (022) 48937160
- Kolkata: (033) 40836441
- Chennai: (044) 48137110
- Bangalore: (080) 45684079
- Hyderabad: (040) 49171772
- Ahmedabad: (079) 49107674
Conclusion
Whole Exome Sequencing is a powerful, comprehensive genetic tool for identifying the root cause of complex genetic disorders. With expert guidance, advanced NGS technology, and convenient sample collection, DNA Labs India ensures accurate, reliable, and timely results to help you make informed healthcare decisions.