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ADAM10 Gene Alzheimer Disease Type 18, Susceptibility to NGS Genetic Test

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ADAM10 Gene Alzheimer Disease Type 18, Susceptibility to NGS Genetic Test

Short Name: ADAM10 NGS Test

Also known as: ADAM10 Gene Mutation Test, Alzheimer Susceptibility Genetic Test, ADAM10 NGS Panel, Alzheimer Disease Type 18 Risk Assessment

ADAM10 Gene Alzheimer Disease Type 18, Susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Whole Blood (EDTA) samples. Results in Reports will be available approximately 3 to 4 weeks after the sample is received at the laboratory. Reports are delivered online, by email and through WhatsApp.. Free home collection in 300+ cities across India.

NGS Genetic TestAdults (18+)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify clinically significant variants in the ADAM10 gene that are associated with susceptibility to Alzheimer disease type 18. NGS enables high-throughput, high-resolution analysis of the ADAM10 coding sequence and splice junctions. This may help clarify whether an individual has a genetic predisposition, assist family members in understanding their inherited risk, and support informed discussions about future care planning. It is not a diagnostic test for dementia; it is a susceptibility and risk assessment test and should be interpreted together with clinical history, cognitive assessment and family pedigree.

Test Code
3868
Price
₹20,000
Sample Type
Whole Blood (EDTA)
Result Time
Reports will be available approximately 3 to 4 weeks after the sample is received at the laboratory. Reports are delivered online, by email and through WhatsApp.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. Pre-test genetic counselling is mandatory to discuss the purpose, benefits, limitations and possible implications of the test. Please bring a valid government ID, clinical referral or previous investigative reports if available.

Method: Peripheral venous blood draw by trained phlebotomist

Step 2

Laboratory Analysis

A qualified phlebotomist will collect a venous blood sample into an EDTA tube. The procedure usually takes about 10 minutes. You may feel a mild pinprick or temporary discomfort at the site.

Step 3

Report Delivery

There is no restriction on daily activities after blood collection. The sample will be processed in the laboratory for DNA extraction and NGS analysis. You will receive electronic acknowledgement and a report link once results are ready.

Timeline: Reports will be available approximately 3 to 4 weeks after the sample is received at the laboratory. Reports are delivered online, by email and through WhatsApp.

Patient Instructions

1
Before the Test:Pre-test genetic counselling is required. The counsellor will review the family history, draw a pedigree chart and explain the implications of the result. No special preparation or fasting is needed.
2
During the Test:A blood sample is collected from a vein in the arm. The sample is sent to the laboratory where DNA is isolated and the ADAM10 gene is analysed using Next Generation Sequencing.
3
After the Test:You can resume normal activities immediately. The laboratory will process the sample and the report will be shared within 3 to 4 weeks. A post-test genetic counselling session is recommended to explain the result.

About This Test

Who Should Get This Test

The purpose of this test is to identify clinically significant variants in the ADAM10 gene that are associated with susceptibility to Alzheimer disease type 18. NGS enables high-throughput, high-resolution analysis of the ADAM10 coding sequence and splice junctions. This may help clarify whether an individual has a genetic predisposition, assist family members in understanding their inherited risk, and support informed discussions about future care planning. It is not a diagnostic test for dementia; it is a susceptibility and risk assessment test and should be interpreted together with clinical history, cognitive assessment and family pedigree.

How to Prepare

  • Pre-test genetic counselling session is required before sample collection.
  • Fasting is not required for this test.
  • Inform the phlebotomist if you have a bleeding disorder or are taking anticoagulant medication.
  • Only the EDTA tube provided by DNA Labs India should be used.
  • Ensure the sample tube is labelled with your unique barcode and identity details.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"A positive ADAM10 result is not a diagnosis of Alzheimer disease; it provides susceptibility information. Clinical correlation and genetic counselling are mandatory."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood (EDTA)
Sample Volume2-3 mL
ContainerEDTA lavender-top tube
Collection MethodPeripheral venous blood draw by trained phlebotomist

Sample Stability

Whole blood at room temperature: process within 8 hours of collection
Whole blood at 2-8°C: stable for up to 24 hours
Extracted DNA at 2-8°C: stable for up to 7 days
Extracted DNA at -20°C: stable for long-term storage
Sample Rejection Criteria:
  • Clotted or haemolysed sample
  • Sample received after more than 24 hours without cold chain
  • Incorrectly labelled or unlabelled sample
  • Sample collected in a sodium heparin or non-EDTA tube

Understanding Your Results

This NGS genetic test identifies variants in the ADAM10 gene that may increase susceptibility to Alzheimer disease type 18. The report should be interpreted by a neurologist or clinical geneticist in the context of the patient's clinical picture, family history and the results of genetic counselling.
📊

Susceptibility to ADAM10-related Alzheimer disease type 18 is increased. The variant is not deterministic; clinical follow-up, counselling and family testing should be considered.

Result type: Pathogenic/likely pathogenic variant detected

📊

The clinical significance is not yet known. Additional family segregation studies or functional evidence may be needed before clinical action.

Result type: Variant of uncertain significance (VUS) detected

📊

No reportable ADAM10 susceptibility variant was found. This does not exclude Alzheimer disease caused by other genes or non-genetic factors.

Result type: No pathogenic/likely pathogenic variant detected

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist if you have progressive memory loss, functional decline, behavioural changes, a positive genetic risk result, or a family history of early-onset Alzheimer disease.

Limitations

  • ⚠Targeted NGS may not reliably detect large deletions, duplications, repeat expansions or deep intronic variants.
  • ⚠A negative result does not exclude all genetic or non-genetic causes of Alzheimer disease.
  • ⚠A variant of uncertain significance may be reported; it should not be used alone for clinical decisions.
  • ⚠The test evaluates only ADAM10 and does not cover other genes associated with Alzheimer disease.
  • ⚠Positive susceptibility results do not predict age of onset or severity.

Risks & Considerations

  • ●Mild pain, redness or bruising at the venipuncture site
  • ●Slight dizziness or fainting during blood collection
  • ●Psychological anxiety or stress related to genetic risk information

Interfering Factors

  • ●Inadequate DNA quantity or quality
  • ●Contamination of the blood sample
  • ●Presence of variants outside the targeted coding and splice-site regions
  • ●Grossly haemolysed or clotted sample

Frequently Asked Questions

What is the ADAM10 gene and why is it tested?
ADAM10 encodes a metallopeptidase involved in the regulated cleavage of amyloid precursor protein. Some ADAM10 variants have been reported in families with Alzheimer disease, and this NGS test sequences the gene to detect such variants.
What is Alzheimer disease type 18?
Alzheimer disease type 18 is a genetic classification used for ADAM10-related susceptibility to Alzheimer's disease. The term susceptibility means the variant may increase the lifetime risk but does not guarantee that the disease will occur.
Does this test diagnose Alzheimer disease?
No. This is a susceptibility and risk assessment test. It evaluates the ADAM10 gene for variants associated with a higher chance of developing Alzheimer disease. The clinical diagnosis is made by a neurologist using medical history, neurological examination, cognitive testing and sometimes imaging or biomarkers.
Who should consider this test?
People with a family history of early-onset Alzheimer disease, a known ADAM10 variant in the family, or unexplained progressive cognitive decline may be offered this test by a clinical geneticist or neurologist after pre-test counselling.
What is the cost of this test?
The price of the ADAM10 Gene Alzheimer Disease Type 18 Susceptibility to NGS Genetic Test at DNA Labs India is INR 20,000. This includes genetic counselling, NGS analysis and the interpretation report. Free home sample collection is available for online bookings.
What sample is needed?
A whole blood sample in an EDTA tube is collected from a vein. No fasting is required. The sample is sent to the laboratory for DNA extraction and targeted NGS analysis.
How long does this test take?
The usual turnaround time is 3 to 4 weeks from the date the sample is received at the laboratory. Reports are delivered online, by email or WhatsApp.
What could a positive result mean?
A positive result means a pathogenic or likely pathogenic ADAM10 variant has been found. It indicates increased susceptibility to Alzheimer disease type 18, but it does not mean the disease is certain. A clinical geneticist or neurologist should discuss the result and plan follow-up.
What does a negative result mean?
A negative result means no clinically significant ADAM10 variant was detected in the gene regions tested. It does not exclude all genetic or non-genetic causes of Alzheimer disease. Sporadic late-onset Alzheimer disease can still occur.
Can a variant of uncertain significance be reported?
Yes. NGS may identify DNA changes whose effect is not yet clear. This is called a variant of uncertain significance, or VUS. A VUS should not be treated as a disease-causing variant. Family studies or further clinical evaluation may help clarify its significance.
Do I need genetic counselling before the test?
Pre-test genetic counselling is recommended and is part of the DNA Labs India process. A genetic counsellor reviews the family history, draws a pedigree, explains the benefits and limitations, and obtains informed consent before testing.
Is this test covered by insurance?
Insurance coverage varies by policy and provider. Government schemes such as PMJAY, CGHS, ECHS and ESIC generally do not cover predictive genetic susceptibility tests. You should confirm with your insurer for pre-authorisation before undergoing testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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