ADGRG1 Gene Polymicrogyria bilateral frontoparietal NGS Genetic Test
Short Name: ADGRG1 Polymicrogyria NGS
Also known as: ADGRG1 Gene Mutation Test, Bilateral Frontoparietal Polymicrogyria Genetic Test, Polymicrogyria NGS Panel
ADGRG1 Gene Polymicrogyria bilateral frontoparietal NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of this test is to identify disease-causing variants in the ADGRG1 gene that are associated with bilateral frontoparietal polymicrogyria. This genetic confirmation helps in: 1) Establishing a definitive diagnosis in individuals with clinical features suggestive of polymicrogyria, 2) Differentiating from other genetic causes of polymicrogyria, 3) Providing accurate recurrence risk for family planning, 4) Guiding management and surveillance strategies, 5) Enabling prenatal diagnosis in future pregnancies if a pathogenic variant is identified.
- Test Code
- 5909
- CPT Code
- 81407
- ICD Code
- Q04.8
- Price
- ₹20,000
- Sample Type
- Blood
- Result Time
- Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a genetic counseling session is recommended before the test to discuss the implications and obtain informed consent.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.
Report Delivery
You can resume normal activities immediately. The sample will be sent to the laboratory for analysis.
Timeline: Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this test is to identify disease-causing variants in the ADGRG1 gene that are associated with bilateral frontoparietal polymicrogyria. This genetic confirmation helps in: 1) Establishing a definitive diagnosis in individuals with clinical features suggestive of polymicrogyria, 2) Differentiating from other genetic causes of polymicrogyria, 3) Providing accurate recurrence risk for family planning, 4) Guiding management and surveillance strategies, 5) Enabling prenatal diagnosis in future pregnancies if a pathogenic variant is identified.
How to Prepare
- No fasting required.
- Inform the lab if you have had a blood transfusion in the past 3 months.
- Ensure the sample is collected in the provided EDTA tube.
- For home collection, keep the sample at room temperature until pickup.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for ADGRG1 is crucial for confirming polymicrogyria diagnosis, guiding prognosis, and enabling accurate genetic counseling for families."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Incorrect tube used (e.g., heparin instead of EDTA)
- Sample received after more than 72 hours at room temperature
- Insufficient sample volume
Understanding Your Results
Positive (Pathogenic variant detected)
Confirms the diagnosis of ADGRG1-related polymicrogyria. Genetic counseling is recommended for the family.
Negative (No pathogenic variant detected)
Does not rule out polymicrogyria; other genetic or non-genetic causes may be considered. Further testing may be advised.
Variant of Uncertain Significance (VUS)
A variant was found but its clinical significance is unknown. Additional testing or family studies may be needed.
Consult your healthcare provider if you or your child experience symptoms such as developmental delay, seizures, or abnormal brain MRI findings. Genetic counseling is recommended before and after the test.
Limitations
- ⚠This test only analyzes the ADGRG1 gene; other genes associated with polymicrogyria are not covered.
- ⚠It does not detect large chromosomal rearrangements or copy number variations.
- ⚠Variants of uncertain significance (VUS) may be reported; further testing may be required.
- ⚠Negative results do not exclude a genetic cause; other genes or non-genetic etiologies may be responsible.
- ⚠This test is not intended for prenatal diagnosis without prior genetic counseling.
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of receiving genetic results
- ●Potential for uncertain results (VUS) requiring further testing
Interfering Factors
- ●Contamination of blood sample during collection
- ●Insufficient DNA quantity or quality
- ●Presence of maternal cell contamination in prenatal samples
- ●Rare genetic variants in non-coding regions not covered by this test
- ●Large deletions/duplications not detected by standard NGS sequencing
Compare With Similar Tests
| Test | ADGRG1 Gene Polymicrogyria bilateral frontoparietal NGS Genetic Test | Polymicrogyria Gene Panel (Multiple Genes) | Whole Exome Sequencing (WES) | Chromosomal Microarray (CMA) |
|---|---|---|---|---|
| Comparison | ADGRG1 Gene Polymicrogyria bilateral frontoparietal NGS Genetic Test | This panel tests multiple genes associated with polymicrogyria, including ADGRG1, GPR56, and others. It is more comprehensive but may be more expensive. | WES analyzes all coding regions of the genome, providing a broader diagnostic yield. It is more expensive and may take longer. | CMA detects copy number variations and is useful for identifying deletions/duplications. It does not detect single nucleotide variants. |
Frequently Asked Questions
What is the cost of the ADGRG1 gene polymicrogyria NGS genetic test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get the results?
What does a positive result mean?
Can this test be done for prenatal diagnosis?
Is home sample collection available?
What is the turnaround time for outstation samples?
Are there any risks associated with the test?
Will insurance cover this test?
What is the difference between this test and a full gene panel?
Can I get a genetic counseling session before the test?
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