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AFG3L2 Gene Spinocerebellar ataxia type 28, autosomal dominant NGS Genetic Test

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AFG3L2 Gene Spinocerebellar ataxia type 28, autosomal dominant NGS Genetic Test

Short Name: AFG3L2 SCA28 NGS Test

Also known as: SCA28, Spinocerebellar ataxia type 28

AFG3L2 Gene Spinocerebellar ataxia type 28, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic TestAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Spinocerebellar ataxia type 28 (SCA28) by detecting mutations in the AFG3L2 gene using next-generation sequencing. It helps confirm clinical suspicion, guide treatment options, and facilitate genetic counseling for patients and their families.

Test Code
1839
Price
₹20,000
Sample Type
Blood
Result Time
3-4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and genetic counseling information.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counseling recommended. Provide detailed clinical and family history.
2
During the Test:Blood sample drawn and sent for NGS analysis in the laboratory.
3
After the Test:Wait for results. Genetic counseling session advised for result interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Spinocerebellar ataxia type 28 (SCA28) by detecting mutations in the AFG3L2 gene using next-generation sequencing. It helps confirm clinical suspicion, guide treatment options, and facilitate genetic counseling for patients and their families.

How to Prepare

  • Ensure patient identification is verified
  • Use sterile techniques for blood collection
  • Label the sample correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This NGS genetic test is essential for confirming SCA28 diagnosis, guiding management decisions, and enabling genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume5-10 mL
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Store blood sample at 2-8°C
Stable for up to 24 hours before processing
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate whether pathogenic variants in the AFG3L2 gene are detected, which are associated with SCA28.
Negative result: No pathogenic variant detected; clinical correlation recommended
Positive result: Pathogenic variant detected; confirms diagnosis of SCA28
Variant of uncertain significance (VUS): Further testing or family studies may be needed
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of ataxia, have a family history of SCA28, or receive a positive test result for management and genetic counseling.

Limitations

  • ⚠Test may not detect all possible mutations in the AFG3L2 gene
  • ⚠Results require interpretation by a genetic counselor or specialist
  • ⚠Test does not predict disease severity or progression

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Very rare risk of infection

Compare With Similar Tests

TestAFG3L2 Gene Spinocerebellar ataxia type 28, autosomal dominant NGS Genetic TestATXN1 Gene Spinocerebellar ataxia type 1 NGS TestATXN3 Gene Spinocerebellar ataxia type 3 NGS Test
ComparisonAFG3L2 Gene Spinocerebellar ataxia type 28, autosomal dominant NGS Genetic Test

Frequently Asked Questions

What is the AFG3L2 Gene SCA28 NGS Genetic Test?
This test uses next-generation sequencing to detect mutations in the AFG3L2 gene, which causes Spinocerebellar ataxia type 28 (SCA28), a rare neurological disorder.
What are the common symptoms of SCA28?
Symptoms include difficulty with balance and coordination, trouble walking, muscle stiffness, speech difficulties, loss of fine motor skills, and memory problems.
How is SCA28 diagnosed?
Diagnosis involves clinical examination, genetic testing for AFG3L2 mutations, and imaging studies like MRI. The NGS test is the most reliable method.
What is the cost of this genetic test at DNA Labs India?
The cost is INR 20,000, including sample collection, DNA extraction, sequencing, and analysis.
Is the test covered by insurance?
Typically, genetic testing for SCA28 is not covered by insurance in most cases. Check with your provider for specific coverage.
How long does it take to get results?
Results are usually available within 3-4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What sample type is required for this test?
A blood sample is required, collected via venipuncture.
Is fasting required before the test?
No, fasting is not required for this genetic test.
What are the risks associated with the test?
Risks are minimal, including minor bruising or discomfort at the blood draw site. Serious complications are very rare.
Who should consider getting this test?
Individuals with symptoms of ataxia, a family history of SCA28, or those seeking genetic counseling for neurological conditions.
What happens if the test result is positive?
A positive result confirms SCA28 diagnosis. Consult a healthcare provider for management, treatment options, and genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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