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Amyotrophic Lateral Sclerosis (ALS) Panel NGS Genetic Test

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Amyotrophic Lateral Sclerosis (ALS) Panel NGS Genetic Test

Short Name: ALS Panel NGS

Also known as: ALS Genetic Panel, Lou Gehrig's Disease Genetic Test, Motor Neuron Disease Genetic Panel, ALS Mutation Screening

Amyotrophic Lateral Sclerosis (ALS) Panel NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or Dried Blood Spot (FTA Card) samples. Results in Reports are typically available 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

This test is intended to detect pathogenic variants in genes associated with amyotrophic lateral sclerosis. It assists healthcare providers in confirming a genetic etiology, guiding management, and offering risk assessment to family members.

Test Code
3842
Price
₹20,000
Sample Type
Blood or Extracted DNA or Dried Blood Spot (FTA Card)
Result Time
Reports are typically available 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting required. Please bring prior medical records and a valid ID. Genetic counseling is recommended before testing to understand the implications.

Method: Venipuncture or Finger-prick

Step 2

Laboratory Analysis

A small sample of blood will be collected or an FTA card (dried blood spot) may be used. The process is quick and minimally painful.

Step 3

Report Delivery

No restrictions. You can resume normal activities immediately.

Timeline: Reports are typically available 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Before the test, review your family history with a counselor. Understand what the test can and cannot tell you. Provide informed consent.
2
During the Test:You will provide a small blood sample or dried blood spot. No pain other than a slight prick.
3
After the Test:Wait for reports in 3-4 weeks. A genetic counselor will explain your results if you opt for the counseling session.

About This Test

Who Should Get This Test

This test is intended to detect pathogenic variants in genes associated with amyotrophic lateral sclerosis. It assists healthcare providers in confirming a genetic etiology, guiding management, and offering risk assessment to family members.

How to Prepare

  • No special preparation or fasting is required.
  • Inform the laboratory if you have undergone bone marrow transplantation.
  • For FTA card collection, clean fingertip with alcohol and allow to dry before pricking.
  • Ensure the sample is labeled clearly with name and date of birth.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for ALS can be transformative for families with a hereditary component. It provides clarity on recurrence risks and helps individuals make informed reproductive choices. I always emphasize genetic counseling before and after testing."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or Dried Blood Spot (FTA Card)
Sample VolumeWhole Blood: 2 mL; DNA: 1-2 µg; FTA Card: 1 drop
ContainerEDTA vial, DNA tube, or FTA card
Collection MethodVenipuncture or Finger-prick

Sample Stability

Whole blood in EDTA: 24-48 hours at 2-8°C
Extracted DNA: 1 week at 2-8°C; long-term at -20°C
Dried blood spot (FTA card): stable at room temperature for several months
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Incorrectly labeled sample
  • Insufficient sample volume
  • Sample in wrong container (e.g., serum tube instead of EDTA)
  • Poorly stored FTA card (exposed to moisture or extreme heat)

Understanding Your Results

Results should be interpreted by a qualified geneticist in the context of clinical findings and family history.
Pathogenic variant detected: Indicates a genetic cause may be responsible; discuss clinical implications and family risk.
Variant of uncertain significance (VUS): Insufficient evidence to determine causality; further analysis may be needed.
No pathogenic variant detected: Reduces the likelihood of a genetic cause, but does not rule out ALS.
Negative result in an asymptomatic relative of an affected proband: Confirms low risk if the familial mutation is ruled out.
⚠️ When to Consult a Doctor:

If you receive results, schedule an appointment with your physician or a genetic counselor to discuss the medical and psychological impact. Also if symptoms progress or new symptoms appear, consult your neurologist.

Limitations

  • ⚠NGS may not detect large deletions/duplications, certain repeat expansions, or mitochondrial variants
  • ⚠Results may include variants of uncertain significance (VUS)
  • ⚠A negative result does not exclude the possibility of ALS
  • ⚠Genetic testing cannot replace clinical diagnosis of ALS
  • ⚠Panel content may not include every gene associated with ALS

Risks & Considerations

  • ●No physical risks beyond slight pain or bruising at the blood draw site.
  • ●Psychological impact of receiving positive risk information.
  • ●Potential to discover unsuspected or secondary findings.
  • ●Risk of genetic discrimination if not guided by legislation.

Interfering Factors

  • ●Poor DNA quality from hemolyzed or clotted samples
  • ●Low DNA concentration
  • ●Presence of PCR inhibitors
  • ●Genetic rearrangement or structural variant not detected by NGS
  • ●Mutations in deep intronic or regulatory regions not covered by panel

Compare With Similar Tests

TestAmyotrophic Lateral Sclerosis (ALS) Panel NGS Genetic TestALS Panel NGSWhole Exome Sequencing (WES)Single Gene Testing
ComparisonAmyotrophic Lateral Sclerosis (ALS) Panel NGS Genetic Test

Frequently Asked Questions

What is the ALS Panel NGS Genetic Test?
This is a next-generation sequencing test that analyzes multiple genes linked to amyotrophic lateral sclerosis (ALS) to detect harmful genetic mutations.
How is the ALS genetic test performed?
A small blood sample or dried blood spot is collected and sent to the lab where NGS technology sequences the ALS-associated genes.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, and free home sample collection is available in many cities.
Do I need to fast for this test?
No, fasting is not required. You can eat and drink normally before the test.
What sample is needed for the test?
Samples can include whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card.
How long does it take to get the reports?
Your report is usually delivered within 3 to 4 weeks after the sample is received by the laboratory.
Who should consider this genetic test?
People with ALS symptoms, a family history of ALS, or physicians seeking to confirm a genetic cause may consider testing.
Can this test diagnose ALS?
No. It detects genetic variants linked to ALS, but diagnosis is still based on clinical examination and other tests.
What does a positive test result mean?
A positive result means a disease-causing mutation was found, indicating a possible genetic component in the person's ALS.
What does a negative test result mean?
A negative result means no disease-causing variants were found in the genes analyzed. However, it does not rule out ALS.
Are there any risks involved?
The physical risks are minimal, limited to discomfort from a blood draw. Psychological and family risks should be discussed with a counselor.
How do I book the test?
You can book online on the DNA Labs India website, and we will arrange free home sample collection at your convenience.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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