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ANG Gene Amyotrophic Lateral Sclerosis Type 9 NGS Genetic Test

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ANG Gene Amyotrophic Lateral Sclerosis Type 9 NGS Genetic Test

Short Name: ANG Gene ALS9 NGS Test

Also known as: ANG Gene ALS Test, ALS9 Genetic Test, Angiogenin Gene Mutation Test

ANG Gene Amyotrophic Lateral Sclerosis Type 9 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger sequencing for variant validation on Blood / Extracted DNA / One drop blood on FTA card samples. Results in Samples are processed upon receipt. Reports are typically delivered within 21–28 working days. Delays due to repeat testing or Sanger confirmation may occur.. Free home collection in 300+ cities across India.

NGS Genetic TestAll ages with symptoms or familial risk🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of the ANG Gene ALS Type 9 NGS Genetic Test is to identify pathogenic variants in the ANG gene that cause Amyotrophic Lateral Sclerosis Type 9. It is used to confirm a clinical diagnosis, support familial risk assessment, and aid in early intervention and management planning.

Test Code
3885
CPT Code
81406
ICD Code
G12.21
Price
₹20,000
Sample Type
Blood / Extracted DNA / One drop blood on FTA card
Result Time
Samples are processed upon receipt. Reports are typically delivered within 21–28 working days. Delays due to repeat testing or Sanger confirmation may occur.
Fasting Required
No
Method
Next Generation Sequencing (NGS), Sanger sequencing for variant validation
Step 1

Sample Collection

No special preparation is required. A genetic counseling session is recommended before testing to draw a three-generation pedigree and discuss possible outcomes and limitations.

Method: Venipuncture or Finger prick for FTA card

Step 2

Laboratory Analysis

The sample is collected by a trained phlebotomist. For FTA card, a simple finger-prick is performed. Minimal discomfort may occur.

Step 3

Report Delivery

No restrictions after sample collection. You may resume normal activities immediately.

Timeline: Samples are processed upon receipt. Reports are typically delivered within 21–28 working days. Delays due to repeat testing or Sanger confirmation may occur.

Patient Instructions

1
Before the Test:You will meet a genetic counselor who will explain the purpose, benefits, and limitations of the test. A detailed family history is reviewed. No medical preparation required.
2
During the Test:A small blood sample or FTA card blood spot is collected from you. The process takes about 10 minutes. You can remain seated throughout.
3
After the Test:You will receive the report within 3-4 weeks. A post-test genetic counseling session is recommended to discuss the results and their implications.

About This Test

Who Should Get This Test

The purpose of the ANG Gene ALS Type 9 NGS Genetic Test is to identify pathogenic variants in the ANG gene that cause Amyotrophic Lateral Sclerosis Type 9. It is used to confirm a clinical diagnosis, support familial risk assessment, and aid in early intervention and management planning.

How to Prepare

  • EDTA blood sample should be mixed gently to prevent clotting.
  • FTA card samples should be air-dried and stored in a sterile pouch.
  • Do not refrigerate or freeze FTA cards.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for ALS type 9 is important for confirming diagnosis, risk assessment for family members, and counseling family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood / Extracted DNA / One drop blood on FTA card
Sample Volume2 mL blood or One FTA card spot
ContainerEDTA tube / FTA card
Collection MethodVenipuncture or Finger prick for FTA card

Sample Stability

Whole blood (EDTA): Stable for 48 hours at ambient temperature, 7 days at 2-8°C
Extracted DNA: Stable for 6 months at -20°C
FTA card: Stable for years at room temperature in a dry environment
Sample Rejection Criteria:
  • Hemolyzed blood sample
  • Clotted EDTA sample
  • Incorrect or missing patient identification
  • Improperly transported or leaking sample

Understanding Your Results

The interpretation of ANG gene genetic testing is performed by clinical geneticists and molecular pathologists. Results are categorized based on standardized variant classification guidelines.
📊

Negative (No pathogenic variant detected)

No disease-causing mutation was found in the ANG gene. ALS Type 9 is less likely, but other genetic or non-genetic causes should be considered.

Action: Discuss further genetic testing options with your clinician or genetic counselor.

📊

Positive (Pathogenic variant detected)

A known disease-causing mutation in the ANG gene was identified. This confirms the genetic diagnosis of ALS Type 9 in the appropriate clinical context.

Action: Early intervention, symptom management, and family cascade screening should be initiated.

📊

Variant of Uncertain Significance (VUS)

A genetic change was found but its association with ALS is not yet established. It may require further research and family segregation analysis.

Action: Consult a genetic counselor for further testing of family members and eventual reclassification.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience any symptoms suggestive of ALS, such as progressive muscle weakness, difficulty swallowing or breathing, or if you have a first-degree relative with ALS. Early diagnosis can help in managing symptoms and planning for clinical care.

Limitations

  • ⚠NGS may not detect large gene deletions, duplications, or repeat expansions
  • ⚠Mutations in non-coding regulatory regions may not be identified by standard NGS
  • ⚠A variant of uncertain significance (VUS) may require additional family studies and follow-up
  • ⚠A negative result does not rule out ALS caused by other genes
  • ⚠Results are not intended to replace clinical neurological diagnosis

Risks & Considerations

  • ●No significant physical risks from sample collection
  • ●Potential psychological distress from discovering a genetic predisposition
  • ●Risk of genetic discrimination from employers or insurers if results are misused
  • ●Incidental findings may be reported if consent is given

Interfering Factors

  • ●Poor DNA quality or insufficient sample quantity
  • ●Contamination during DNA extraction
  • ●Presence of rare benign polymorphisms that may complicate interpretation
  • ●Sample mix-up or labeling errors

Compare With Similar Tests

TestANG Gene Amyotrophic Lateral Sclerosis Type 9 NGS Genetic TestSOD1 Gene ALS Type 1 NGS TestC9orf72 Gene ALS/FTD NGS TestTARDBP Gene ALS Type 10 NGS TestFUS Gene ALS Type 6 NGS Test
ComparisonANG Gene Amyotrophic Lateral Sclerosis Type 9 NGS Genetic Test

Frequently Asked Questions

What is the ANG gene?
The ANG gene provides instructions for making a protein called angiogenin, which plays a role in the formation of blood vessels and helps protect nerve cells. Mutations in this gene are associated with familial ALS Type 9.
What is Amyotrophic Lateral Sclerosis Type 9?
ALS Type 9 is a rare inherited form of ALS caused by mutations in the ANG gene. It is characterized by progressive degeneration of motor neurons, leading to muscle weakness and paralysis.
Who should consider this genetic test?
Individuals with symptoms suggestive of ALS, those with a family history of ALS, or people seeking to confirm a diagnosis of ALS Type 9 after clinical evaluation may consider this test.
How is the test performed?
A small blood sample is collected in an EDTA tube, or a blood spot is collected on an FTA card. Alternatively, extracted DNA can be submitted. The sample is analyzed using next-generation sequencing (NGS).
Is fasting required before the test?
No. Fasting is not required for this genetic test. You can eat and drink normally before sample collection.
How long will it take to get the report?
Reports are usually delivered within 3 to 4 weeks (21-28 days) after the sample reaches the laboratory.
What does a positive ANG result mean?
A positive result means a disease-causing pathogenic variant was identified in the ANG gene. This confirms the genetic diagnosis of ALS Type 9 in the appropriate clinical context and allows family screening.
What does a negative result mean?
A negative result means no pathogenic variant was found in the ANG gene. However, it does not completely exclude ALS caused by other genetic or non-genetic factors, so your doctor may recommend further testing.
Could insurance cover this test?
Genetic tests are often not covered by standard insurance plans in India. Coverage depends on your policy and the clinical indication. It is best to check with your insurance provider.
Is genetic counseling available?
Yes, genetic counseling is available before and after the test. A clinical geneticist can help you understand the implications of the result and guide you on next steps.
What are the benefits of early diagnosis?
Early diagnosis allows better planning of care, access to clinical trials, and proactive management of symptoms. It also provides important information for family members who may be at risk.
How much does the ANG gene test cost at DNA Labs India?
The ANG Gene ALS Type 9 NGS Genetic Test costs INR 20,000. Free home sample collection is included for online bookings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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