Skip to main content
DNA Labs India

APOE Gene Alzheimer Disease Type 2 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

APOE Gene Alzheimer Disease Type 2 NGS Genetic Test

Short Name: APOE NGS Alzheimer Risk

Also known as: APOE Gene Alzheimer Disease Type 2 NGS Test, APOE e4 Genetic Risk Test, ApoE Gene Variant Analysis for Alzheimer's

APOE Gene Alzheimer Disease Type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The main purpose of this test is to determine an individual's APOE genotype and identify the presence of the ε4 risk allele. The APOE ε4 allele is the strongest single genetic risk factor for late-onset Alzheimer disease. This NGS-based test provides precise allele detection to help clinicians assess disease susceptibility, plan early interventions, and initiate appropriate counselling. The test is especially useful for patients with a family history of Alzheimer's disease or early cognitive decline.

Test Code
3867
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are typically delivered within 3 to 4 weeks from sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting or dietary restriction is required. A genetic counseling session may be scheduled before the test to draw a pedigree chart. Please bring any relevant family history information.

Method: Venipuncture, FTA card blood spot, or saliva collection as per laboratory protocol

Step 2

Laboratory Analysis

Depending on the chosen method, a blood sample will be drawn by a trained phlebotomist, or a drop of blood will be placed on an FTA card, or a saliva sample collected.

Step 3

Report Delivery

No special precautions are required. You may resume normal activities immediately.

Timeline: Reports are typically delivered within 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:No fasting or dietary restriction is required. A genetic counseling session may be scheduled before the test to draw a pedigree chart. Please bring any relevant family history information.
2
During the Test:Depending on the chosen method, a blood sample will be drawn by a trained phlebotomist, or a drop of blood will be placed on an FTA card, or a saliva sample collected.
3
After the Test:No special precautions are required. You may resume normal activities immediately.

About This Test

Who Should Get This Test

The main purpose of this test is to determine an individual's APOE genotype and identify the presence of the ε4 risk allele. The APOE ε4 allele is the strongest single genetic risk factor for late-onset Alzheimer disease. This NGS-based test provides precise allele detection to help clinicians assess disease susceptibility, plan early interventions, and initiate appropriate counselling. The test is especially useful for patients with a family history of Alzheimer's disease or early cognitive decline.

How to Prepare

  • Choose blood sampling, FTA card blood spot, or saliva collection based on your preference and laboratory guidance.
  • Ensure the sample tube or card is labeled with your full name and date of birth.
  • Inform the laboratory if you have undergone a bone marrow transplant, as it may affect results.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for APOE alleles can offer risk stratification for patients presenting with early cognitive impairment, particularly when a family history of Alzheimer disease is present. Physicians often request this test to complement clinical and radiological evaluation and to guide counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture, FTA card blood spot, or saliva collection as per laboratory protocol

Sample Stability

Whole blood: stable for up to 48 hours at ambient temperature
FTA card: stable for years at room temperature
Extracted DNA: stable for 6 months at -20°C
Sample Rejection Criteria:
  • Sample received in an unlabeled or improperly labeled container
  • Grossly hemolyzed or clotted blood sample
  • Quantity not sufficient for DNA extraction
  • FTA card not air-dried before sealing

Understanding Your Results

The APOE gene analysis identifies the ε2, ε3 and ε4 alleles. The ε3/ε3 genotype is the most common and carries an average risk. One ε4 allele raises risk about 2-3 times, and two ε4 alleles about 8-12 times. However, these risk estimates vary among populations and must be interpreted by a clinician.
📊

Protective genotype; lower likelihood of developing Alzheimer disease.

📊

Lower risk compared to ε3/ε3.

📊

Risk may be similar to ε3/ε3; consult with genetic counselor.

📊

Most common genotype; population average for late-onset Alzheimer disease.

📊

Carrying one ε4 allele increases the risk of Alzheimer disease approximately 2-3 fold.

📊

Carrying two ε4 alleles is associated with a significantly increased risk, but not every carrier develops the disease.

⚠️ When to Consult a Doctor:

Consult a physician or genetic counsellor if you experience cognitive changes, have a family history of Alzheimer's disease, or wish to understand your APOE test results in the context of your health.

Limitations

  • ⚠The test identifies only the APOE ε2/ε3/ε4 alleles and does not cover all genes that may influence Alzheimer's disease risk.
  • ⚠A positive APOE ε4 result indicates increased risk, not a diagnosis of Alzheimer's disease.
  • ⚠Negative APOE ε4 status does not exclude the possibility of developing Alzheimer's disease.

Risks & Considerations

  • ●Minor pain or discomfort at the venipuncture site
  • ●Small bruise or hematoma
  • ●Unlikely risk of infection

Interfering Factors

  • ●Bone marrow transplantation or stem cell transplant leading to mixed DNA profile
  • ●Recent allogeneic blood transfusion
  • ●Sample cross-contamination during collection

Frequently Asked Questions

What is the APOE gene test?
The APOE gene test identifies the ?2, ?3 and ?4 alleles in the APOE gene. The ?4 allele is a known genetic risk factor for late-onset Alzheimer disease type 2. DNA Labs India performs this test using Next-Generation Sequencing (NGS) to accurately detect the APOE variants.
What is the cost of the APOE gene NGS genetic test?
The cost of the APOE Gene Alzheimer Disease Type 2 NGS Genetic Test at DNA Labs India is INR 20,000. This includes the test, free home sample collection, and a genetic counselling session.
What is the sample type required?
The test can be performed on a blood sample, extracted DNA sample, or a single drop of blood on an FTA card. Saliva may also be accepted in certain cases.
Is fasting required before the test?
No, fasting is not required for this genetic test. You can eat and drink normally before sample collection.
How long do we receive the test report?
The reports are available within 3 to 4 weeks from sample submission.
Can this test diagnose Alzheimer's disease?
No, this test does not diagnose Alzheimer's disease. It detects the APOE ?4 risk variant, which indicates increased susceptibility. The clinical diagnosis is made by a neurologist based on medical evaluation and brain imaging.
Who should undergo this test?
Individuals with a family history of Alzheimer disease, early memory problems, or those seeking risk stratification as part of preventive health can consider this test. Genetic counselling is recommended.
Does health insurance cover this test?
Genetic tests are usually not covered under standard health insurance policies. However, coverage may vary depending on the provider and policy. We recommend checking with your insurance company.
Are there any risks associated with the test?
The test involves a simple blood collection or finger-prick, which carries minimal risk such as slight bruising at the puncture site.
How does NGS improve the test accuracy?
Next-Generation Sequencing allows high-throughput and accurate analysis of the APOE gene region, ensuring precise zygosity and allele identification compared to older methods.
Can a positive ?4 result be changed by lifestyle?
APOE ?4 is a genetic risk factor; lifestyle changes such as physical activity, diet, and cognitive engagement may help delay the onset of symptoms but cannot alter the genotype. Discuss preventive strategies with your doctor.
What does a negative result mean?
A negative result for the ?4 allele indicates that the common risk allele is absent. This does not guarantee that you will never develop Alzheimer's disease, but the risk is relatively lower.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.