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ARL6IP1 Gene SPG61 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

ARL6IP1 Gene SPG61 NGS Genetic Test

Short Name: SPG61 NGS Genetic Test

Also known as: HSP Genetic Test, ARL6IP1 Mutation Analysis, SPG61 DNA Test

ARL6IP1 Gene SPG61 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric and Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Hereditary Spastic Paraplegia caused by ARL6IP1 gene mutations and to provide genetic counseling for family planning and risk assessment.

Test Code
1814
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks from sample receipt
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session recommended to discuss test implications and draw a family pedigree chart.

Method: Venipuncture for blood collection

Step 2

Laboratory Analysis

Standard blood draw procedure using sterile technique; alternative sample types accepted as per guidelines.

Step 3

Report Delivery

Sample securely packaged and sent to the laboratory for NGS analysis; results interpreted by genetic specialists.

Timeline: 3 to 4 Weeks from sample receipt

Patient Instructions

1
Before the Test:Undergo genetic counseling to understand the test purpose, implications, and provide informed consent; family pedigree chart may be drawn.
2
During the Test:Blood sample collection via venipuncture or alternative sample types; procedure is quick and minimally invasive.
3
After the Test:Wait for 3 to 4 weeks for report generation; receive results via online portal, email, or WhatsApp, followed by counseling session.

About This Test

Who Should Get This Test

To diagnose Hereditary Spastic Paraplegia caused by ARL6IP1 gene mutations and to provide genetic counseling for family planning and risk assessment.

How to Prepare

  • Ensure proper patient identification and labeling
  • Use sterile collection equipment
  • Follow sample handling protocols to avoid contamination
  • Store samples at appropriate temperature until dispatch

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for diagnosing Hereditary Spastic Paraplegia and guiding management and family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood for whole blood samples
ContainerEDTA tube for blood or FTA card
Collection MethodVenipuncture for blood collection

Sample Stability

Whole blood sample stable for 48 hours at room temperature
Extracted DNA stable for up to 6 months at -20°C
FTA card samples stable for extended periods at room temperature
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or clotted blood sample
  • Improperly labeled or contaminated samples
  • Sample degradation due to storage issues

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the ARL6IP1 gene, which are associated with Hereditary Spastic Paraplegia.
📊

Positive for pathogenic variant

Confirms genetic diagnosis of HSP; indicates risk of transmission to offspring and guides management.

📊

Negative for pathogenic variants

No mutations detected in ARL6IP1 gene; HSP less likely but clinical correlation advised due to genetic heterogeneity.

⚠️ When to Consult a Doctor:

If you experience symptoms of HSP such as leg stiffness, walking difficulties, or muscle spasms, or if you have a family history of neurological disorders, consult a neurologist for evaluation and testing.

Limitations

  • ⚠Cannot detect all genetic variants or mutations in other genes
  • ⚠Results must be correlated with clinical symptoms and family history
  • ⚠Not applicable for prenatal diagnosis without additional validation

Risks & Considerations

  • ●Minimal risks from blood draw such as bruising or infection
  • ●Psychological impact of genetic results, requiring counseling support

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Hemolyzed blood sample
  • ●Improper sample storage or transport

Compare With Similar Tests

TestARL6IP1 Gene SPG61 NGS Genetic Test
ComparisonARL6IP1 Gene SPG61 NGS Genetic Test

Frequently Asked Questions

What is the ARL6IP1 Gene SPG61 NGS Genetic Test?
It is a genetic test that uses NGS technology to identify mutations in the ARL6IP1 gene, which is linked to Hereditary Spastic Paraplegia (HSP).
Who should consider getting this test?
Individuals with symptoms of HSP, such as leg stiffness, walking difficulties, or muscle spasms, or those with a family history of HSP or similar neurological disorders.
What are the symptoms of Hereditary Spastic Paraplegia?
Symptoms include stiffness and weakness in the legs, difficulty walking, uncontrollable muscle spasms, urinary urgency and incontinence, and balance issues.
How is the test performed?
The test is performed using Next-Generation Sequencing on a blood sample, extracted DNA, or a blood drop on an FTA card collected via standard procedures.
What is the cost of the ARL6IP1 Gene SPG61 NGS Genetic Test?
The cost is INR 20,000 at DNA Labs India, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample receipt, delivered via online portal, email, or WhatsApp.
What does a positive test result mean?
A positive result indicates the presence of a pathogenic variant in the ARL6IP1 gene, confirming a genetic diagnosis of HSP and indicating risk of transmission to offspring.
Is genetic counseling provided with this test?
Yes, genetic counseling sessions are recommended before and after testing to discuss implications, results, and family planning.
Can this test be used for prenatal diagnosis?
No, this test is not validated for prenatal diagnosis; consult a genetic counselor for appropriate prenatal testing options.
What are the risks associated with this genetic test?
Risks are minimal, primarily related to blood draw (e.g., bruising), but psychological impact may occur, necessitating counseling support.
Is the test covered by insurance?
Coverage depends on your insurance policy; check with your provider. DNA Labs India offers affordable pricing regardless of insurance status.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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