Skip to main content
DNA Labs India

ARSI Gene SPG66, ARSI related NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

ARSI Gene SPG66, ARSI related NGS Genetic Test

Short Name: ARSI Gene SPG66 Test

Also known as: ARSI-related SPG66, Hereditary Spastic Paraplegia 66

ARSI Gene SPG66, ARSI related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the ARSI gene to confirm the diagnosis of Hereditary Spastic Paraplegia Type 66 (SPG66), aiding in clinical management and genetic counseling.

Test Code
1822
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Ensure proper sample handling and documentation of clinical history. Genetic counselling recommended.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Sample collected by trained phlebotomist using aseptic technique.

Step 3

Report Delivery

Sample sent to laboratory for DNA extraction and NGS analysis.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counselling session to draw a pedigree chart and discuss implications. Provide clinical history.
2
During the Test:Blood sample drawn for DNA extraction and Next-Generation Sequencing (NGS) analysis of the ARSI gene.
3
After the Test:Results available in 3-4 weeks; discuss findings with a healthcare provider for management and counseling.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the ARSI gene to confirm the diagnosis of Hereditary Spastic Paraplegia Type 66 (SPG66), aiding in clinical management and genetic counseling.

How to Prepare

  • Use aseptic technique
  • Label sample correctly with patient details
  • Transport at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is crucial for early diagnosis and management of SPG66, enabling personalized care and genetic counseling for affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood stable at 2-8°C for 48 hours
FTA card stable at room temperature for extended periods
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect sample type
  • Damaged FTA card

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the ARSI gene, guiding diagnosis of SPG66.
📊

Pathogenic variant detected

Confirmatory diagnosis of SPG66; genetic counseling recommended

📊

No pathogenic variant detected

SPG66 unlikely, but clinical correlation needed; further testing may be considered

⚠️ When to Consult a Doctor:

Consult a geneticist or neurologist if symptoms suggestive of SPG66 are present, such as leg weakness or spasticity, or if there is a family history of the disorder.

Limitations

  • ⚠Detection limited to known variants
  • ⚠May not detect all types of mutations
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or discomfort
  • ●No significant risks associated with genetic testing itself

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Improper sample storage

Frequently Asked Questions

What is ARSI Gene SPG66?
ARSI Gene SPG66 is a rare genetic disorder caused by mutations in the ARSI gene, leading to hereditary spastic paraplegia type 66, affecting the nervous system.
What are the common symptoms of SPG66?
Common symptoms include weakness in legs, spasticity, difficulty walking, tremors, developmental delays, and intellectual disability.
How is SPG66 diagnosed?
SPG66 is diagnosed through genetic testing, specifically Next-Generation Sequencing (NGS), to detect mutations in the ARSI gene.
What is the cost of the ARSI Gene SPG66 NGS Genetic Test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available.
How is the genetic test performed?
A blood sample or extracted DNA is analyzed using NGS technology to identify mutations in the ARSI gene.
Is fasting required for this test?
No, fasting is not required. The test can be done at any time.
How long does it take to get the results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What should I do before the test?
A genetic counselling session is recommended to discuss clinical history and draw a family pedigree chart.
How accurate is this test?
The test uses NGS technology, which is highly accurate for detecting known mutations, but results should be correlated with clinical findings.
Can this test detect all mutations in the ARSI gene?
The test detects a wide range of mutations, but may not identify all possible variants due to limitations in current technology.
What are the risks associated with this test?
Risks are minimal, primarily related to blood draw, such as bruising. Genetic testing itself poses no physical risks.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.