Ataxia Comprehensive Panel NGS Genetic Test
Short Name: Ataxia NGS Panel
Also known as: Ataxia Comprehensive Panel, Hereditary Ataxia NGS Panel, Spinocerebellar Ataxia Gene Panel
Ataxia Comprehensive Panel NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or FTA Card samples. Results in The normal turnaround time is 3 to 4 weeks. This duration is necessary to complete high-throughput sequencing, bioinformatics analysis, variant curation, and clinical review.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the Ataxia Comprehensive Panel NGS Genetic Test is to detect pathogenic genetic variants that may explain the clinical symptoms of ataxia. A definitive molecular diagnosis is essential for accurate genetic counselling, predicting disease course, guiding symptomatic management, and enabling family members to make informed decisions about their health.
- Test Code
- 3848
- ICD Code
- G11
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or FTA Card
- Result Time
- The normal turnaround time is 3 to 4 weeks. This duration is necessary to complete high-throughput sequencing, bioinformatics analysis, variant curation, and clinical review.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting or special preparation is required. Please provide a detailed clinical history and any available family pedigree. Genetic counselling prior to the test is mandatory and will be arranged by DNA Labs India.
Method: Peripheral venipuncture / FTA card blood spot
Laboratory Analysis
A professionally trained phlebotomist will collect 2-3 ml of venous blood in an EDTA tube. Alternatively, a single drop of blood can be placed on the FTA card. The sample is labelled and transported to the laboratory at ambient temperature.
Report Delivery
You can resume normal activities immediately. There are no post-procedure restrictions. Reports will be prepared and shared within 3 to 4 weeks through the chosen delivery channel.
Timeline: The normal turnaround time is 3 to 4 weeks. This duration is necessary to complete high-throughput sequencing, bioinformatics analysis, variant curation, and clinical review.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Ataxia Comprehensive Panel NGS Genetic Test is to detect pathogenic genetic variants that may explain the clinical symptoms of ataxia. A definitive molecular diagnosis is essential for accurate genetic counselling, predicting disease course, guiding symptomatic management, and enabling family members to make informed decisions about their health.
How to Prepare
- No fasting is required.
- Notify the laboratory if you have received a blood transfusion or bone marrow transplant in the past 6 months.
- Wear comfortable clothing for easy access to the antecubital vein.
- An appointment with the genetic counsellor will be scheduled before sample collection.
- For FTA card sampling, ensure the card is dry after blood spot before packing.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for ataxia is critical because a precise molecular diagnosis can provide closure to families, guide surveillance and management, and enable informed family planning. As a neurologist, I ensure genetic counselling is embedded in every step of this process."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted blood sample
- Insufficient sample volume
- Hemolyzed blood sample
- Mislabeled or unlabeled sample
- FTA card with insufficient blood spot
- Sample with suspected degradation or contamination
Understanding Your Results
Positive
A pathogenic or likely pathogenic variant is identified. This establishes a molecular diagnosis for ataxia and confirms the genetic cause. Genetic counselling for the patient and at-risk relatives is strongly recommended.
Variant of Uncertain Significance (VUS)
A sequence variant was found, but its effect on health is currently unknown. Additional family testing, bioinformatics evaluation, or functional studies may be needed to reclassify this variant.
Negative
No clinically significant variants were found in the analyzed ataxia genes. A hereditary cause cannot be entirely ruled out. Further testing such as whole exome sequencing or assessment for repeat expansion may be considered.
Consult a neurologist or genetic specialist if you notice any signs of ataxia, including unsteady walking, frequent falls, clumsiness, difficulty speaking or swallowing, or if you have relatives with a diagnosed ataxic disorder. Early diagnosis can significantly improve care.
Limitations
- ⚠NGS-based panels may not reliably detect large trinucleotide repeat expansions typical of some SCA subtypes; repeat-primed analysis or PCR may be needed.
- ⚠Point mutations and small indels are covered, but intronic or regulatory variants beyond target regions will not be detected.
- ⚠A negative result does not exclude hereditary ataxia; other genetic or non-genetic causes may be responsible.
- ⚠Variants of uncertain significance (VUS) may require additional family segregation studies.
- ⚠Clinical correlation and genetic counselling are essential for correct interpretation.
Risks & Considerations
- ●Minor bruising or bleeding at the blood collection site
- ●Mild pain or discomfort during venipuncture
- ●Rare local infection or nerve injury (very uncommon)
Interfering Factors
- ●Low-quality or degraded DNA
- ●Recent allogeneic bone marrow transplant (may cause mixed DNA profile)
- ●Presence of pseudogenes causing mapping ambiguity
- ●Very large repeat expansions not accurately assessed by NGS
- ●Mosaicism may reduce variant detection sensitivity
Compare With Similar Tests
| Test | Ataxia Comprehensive Panel NGS Genetic Test | Targeted Sanger Sequencing | Whole Exome Sequencing (WES) | Repeat Expansion PCR |
|---|---|---|---|---|
| Comparison | Ataxia Comprehensive Panel NGS Genetic Test | Sanger sequencing is used when a specific familial variant is known. It cannot evaluate multiple genes simultaneously as NGS panel does. | WES sequences all coding regions of the genome, which is larger and more expensive, but may identify variants in genes not included in the ataxia panel. | Repeat-specific PCR is essential for detecting large trinucleotide repeat expansions, which are difficult to assess by NGS. It is performed as a complement to the panel. |
Frequently Asked Questions
What is the Ataxia Comprehensive Panel NGS Genetic Test?
What is the cost of this test at DNA Labs India?
Which genes are included in this panel?
Do I need to fast before the test?
What type of sample is needed for this test?
How long does it take to get the test report?
Is home sample collection available?
What is NGS technology?
Will genetic counselling be provided?
Can this test detect trinucleotide repeat expansions such as those in SCA1 or SCA2?
What does a negative result mean?
Is this test covered by medical insurance?
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