Skip to main content
DNA Labs India

ATL3 Gene Neuropathy, hereditary sensory, type 1F NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

ATL3 Gene Neuropathy, hereditary sensory, type 1F NGS Genetic Test

Short Name: ATL3 HSN1F NGS Test

Also known as: Hereditary Sensory Neuropathy Type 1F Genetic Test, ATL3 Gene Mutation NGS Analysis, ATL3 Neuropathy NGS Test

ATL3 Gene Neuropathy, hereditary sensory, type 1F NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks after sample submission.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Vasudeva Rao Pandurangi Sanyasi

Dr Vasudeva Rao Pandurangi Sanyasi

Consultant Neurologist · Reg: AMC4983

Last reviewed: September 7, 2026

Overview

The purpose of this NGS test is to identify a pathogenic variant in the ATL3 gene that may explain symptoms in patients with suspected hereditary sensory neuropathy type 1F. This helps in confirming the clinical diagnosis, determining familial risk, and guiding follow-up care.

Test Code
4431
CPT Code
N/A
ICD Code
N/A
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks after sample submission.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

A genetic counselling session must be completed prior to testing to review the patient's clinical history, draw a family pedigree, and document informed consent. Fasting is not required.

Method: Venipuncture / Dried blood spot (FTA card)

Step 2

Laboratory Analysis

A blood sample is drawn from a vein, or a single blood spot is collected onto an FTA card using a finger-prick. The sample is labelled and prepared for transport.

Step 3

Report Delivery

No specific after-sample care restrictions are required. The sample is couriered to DNA Labs India's laboratory for NGS analysis.

Timeline: 3 to 4 weeks after sample submission.

Patient Instructions

1
Before the Test:Before scheduling the test, the patient should undergo genetic counselling and provide relevant clinical history. No special diet, fasting, or medication changes are needed.
2
During the Test:During the test, a blood sample is collected and sent to the laboratory. The patient may experience minor discomfort at the collection site.
3
After the Test:After sample collection, the patient may resume normal daily activities. Results will be shared in 3 to 4 weeks; a post-test genetic counselling session is recommended.

About This Test

Who Should Get This Test

The purpose of this NGS test is to identify a pathogenic variant in the ATL3 gene that may explain symptoms in patients with suspected hereditary sensory neuropathy type 1F. This helps in confirming the clinical diagnosis, determining familial risk, and guiding follow-up care.

How to Prepare

  • A genetic counselling session should be completed before sample submission.
  • Blood sample must be collected in an EDTA vacutainer or as a dried blood spot on an FTA card.
  • Label the sample clearly with patient name, date, and unique laboratory ID.
  • Please carry the test request form and the genetic counselling referral to the collection center.
  • For home sample collection, confirm the free service at the time of online booking.

Doctor's Notes

Reviewed by — MBBS, MD (Neurology) · Reg. No. AMC4983

"Early molecular confirmation in hereditary sensory neuropathy helps explain the patient's symptoms and enables accurate family counselling. Genetic test results should always be correlated with clinical findings and family history, especially when a novel or uncertain variant is identified."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required by laboratory
ContainerEDTA vacutainer / FTA card / DNA vial
Collection MethodVenipuncture / Dried blood spot (FTA card)

Sample Stability

Whole blood (EDTA)
Extracted DNA
FTA card (dried blood spot)
Sample Rejection Criteria:
  • Mislabeled or unlabeled sample
  • Clotted or heavily haemolysed blood
  • Inadequate DNA quantity after extraction
  • Expired collection tube
  • Sample received after the maximum stability period

Understanding Your Results

The interpretation of genetic data must be performed by a clinical geneticist, neurologist or trained specialist. When a variant is identified, it is classified using internationally accepted ACMG/AMP guidelines. The final report includes clinical correlation and follow-up suggestions.
📊

No causative sequence variant was identified in the ATL3 gene. Other genetic or non-genetic causes may need to be considered.

Recommendation: Correlate with clinical examination and consider a broader neuropathy gene panel if clinical suspicion remains high.

📊

The variant is consistent with a diagnosis of ATL3-related hereditary sensory neuropathy in the appropriate clinical context.

Recommendation: Familial segregation testing and genetic counselling are recommended.

📊

A DNA change was found that is not currently classified as pathogenic or benign.

Recommendation: Further family studies and clinical correlation may help clarify the significance of the variant.

⚠️ When to Consult a Doctor:

Consult a neurologist if you notice progressive loss of sensation, muscle weakness, repeated foot injuries, burning pain, poor balance, or difficulty walking. A clinical geneticist should be consulted after any genetic test result to understand its implications and plan further management.

Limitations

  • ⚠This test is targeted to the ATL3 gene only and does not rule out other hereditary neuropathies.
  • ⚠Large genomic deletions, duplications or structural variants may be missed unless specific copy-number analysis is performed.
  • ⚠A variant of uncertain significance may require additional family studies to determine its clinical relevance.
  • ⚠A negative result does not exclude a genetic cause for the neuropathy.

Risks & Considerations

  • ●Slight pain or bruising at the blood collection site
  • ●Lightheadedness during blood draw
  • ●Very low risk of infection or bleeding
  • ●Psychological impact of receiving genetic results

Interfering Factors

  • ●Insufficient quantity or poor quality of extracted DNA
  • ●Sample degradation during transport
  • ●PCR inhibitors in the sample
  • ●Variants located outside the analysed genomic regions
  • ●Large deletions or structural rearrangements may not be detected by standard NGS

Compare With Similar Tests

TestATL3 Gene Neuropathy, hereditary sensory, type 1F NGS Genetic TestATL3 Targeted NGS Test (This Test)Hereditary Sensory Neuropathy Comprehensive NGS PanelWhole Exome Sequencing (WES)ATL3 Sanger Sequencing
ComparisonATL3 Gene Neuropathy, hereditary sensory, type 1F NGS Genetic Test

Frequently Asked Questions

What is ATL3 gene neuropathy hereditary sensory type 1F NGS genetic test?
It is a targeted next-generation sequencing test that analyzes the ATL3 gene for sequence variants linked to hereditary sensory neuropathy type 1F. It is performed on blood, extracted DNA or an FTA card sample and helps confirm a clinical suspicion of ATL3-related neuropathic disease.
What is the cost of the ATL3 HSN1F NGS genetic test?
The test is available from DNA Labs India at a special discounted price of Rs 20,000 across India.
Is fasting required before the test?
No, fasting is not required before giving the blood sample for this test.
What sample do I need to provide?
The sample can be blood in an EDTA tube, extracted DNA, or one drop of blood collected on an FTA card.
When will I get my report?
The report is usually delivered within 3 to 4 weeks after the sample reaches the laboratory.
What does hereditary sensory neuropathy type 1F mean?
It is a rare genetic disorder associated with mutations in the ATL3 gene, affecting the peripheral nerves and causing progressive loss of sensation and other neurological symptoms.
Is genetic counselling necessary before the test?
Yes, a genetic counselling session is recommended before testing to document clinical history, draw a family pedigree, and understand the implications of the genetic result.
Can this test detect all hereditary neuropathies?
No, this test is specific to the ATL3 gene. A comprehensive neuropathy gene panel or whole exome sequencing may be suggested if the clinical picture is broad or the diagnosis is unclear.
What does a negative result mean?
A negative result means no pathogenic variant was found in the ATL3 gene. However, a genetic cause has not been completely ruled out, and other genes or conditions may need to be considered.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in many cities across India. Please check availability at the time of booking.
How is the ATL3 gene analysed in this test?
DNA is extracted from the sample and the ATL3 gene is enriched and sequenced using Next-Generation Sequencing. The sequencing data is then analysed for mutations, deletions or variants that may cause hereditary sensory neuropathy type 1F.
How should I interpret the result of this test?
Genetic test results should be interpreted by a clinical geneticist, neurologist or genetic counsellor in the context of your symptoms, family history, and clinical examination. Do not interpret the result in isolation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.