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BEAN1 Gene Spinocerebellar ataxia type 31, autosomal dominant NGS Genetic Test

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BEAN1 Gene Spinocerebellar ataxia type 31, autosomal dominant NGS Genetic Test

Short Name: SCA31 NGS Test

Also known as: Spinocerebellar Ataxia Type 31, SCA31

BEAN1 Gene Spinocerebellar ataxia type 31, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the BEAN1 Gene NGS Genetic Test is to detect mutations in the BEAN1 gene for confirming a diagnosis of Spinocerebellar Ataxia Type 31 (SCA31). It helps in identifying affected individuals, guiding treatment strategies, and providing genetic counselling for family members at risk.

Test Code
1841
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history of the patient and undergo a genetic counselling session to draw a pedigree chart of family members affected with SCA31.

Method: Venipuncture

Step 2

Laboratory Analysis

Sample collected via venipuncture or alternative methods as specified (blood, extracted DNA, or FTA card).

Step 3

Report Delivery

Store sample at ambient room temperature and transport to the lab promptly. No specific post-collection care required.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling and clinical history review are required before sample collection.
2
During the Test:NGS sequencing of the BEAN1 gene is performed on the provided sample.
3
After the Test:Results are reviewed by a geneticist, and a clinical report is generated with interpretations.

About This Test

Who Should Get This Test

The purpose of the BEAN1 Gene NGS Genetic Test is to detect mutations in the BEAN1 gene for confirming a diagnosis of Spinocerebellar Ataxia Type 31 (SCA31). It helps in identifying affected individuals, guiding treatment strategies, and providing genetic counselling for family members at risk.

How to Prepare

  • Ensure sample is collected by a trained phlebotomist
  • Use appropriate containers for blood or FTA cards
  • Label samples correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early genetic diagnosis of SCA31 is essential for informed management and family counseling. Individuals with a family history or symptoms should consider genetic testing after consultation."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples: stable at room temperature for up to 48 hours
Extracted DNA: stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Incorrect labeling or insufficient sample volume
  • Expired or contaminated FTA cards

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the BEAN1 gene. A positive result confirms SCA31, while a negative result does not entirely rule out the condition if symptoms persist.
Positive for BEAN1 mutation: Confirms diagnosis of SCA31; genetic counselling recommended for family
Negative for BEAN1 mutation: SCA31 unlikely based on this test; consider other differential diagnoses
Variant of uncertain significance: Requires further clinical evaluation and family studies
⚠️ When to Consult a Doctor:

Consult a neurologist or genetic specialist immediately after receiving positive results for management planning. Seek advice if symptoms persist despite negative results.

Limitations

  • ⚠May not detect all possible BEAN1 gene variants
  • ⚠Results require interpretation by a genetic specialist
  • ⚠Does not predict disease severity or progression

Risks & Considerations

  • ●Psychological impact of positive diagnosis
  • ●Potential for incidental findings
  • ●Emotional stress for family members

Interfering Factors

  • ●Contaminated or degraded DNA samples
  • ●Insufficient sample volume
  • ●Technical errors in NGS sequencing

Compare With Similar Tests

TestBEAN1 Gene Spinocerebellar ataxia type 31, autosomal dominant NGS Genetic TestSCA1 NGS Genetic TestSCA2 NGS Genetic TestSCA3 NGS Genetic Test
ComparisonBEAN1 Gene Spinocerebellar ataxia type 31, autosomal dominant NGS Genetic Test

Frequently Asked Questions

What is Spinocerebellar Ataxia Type 31 (SCA31)?
SCA31 is a rare genetic disorder caused by mutations in the BEAN1 gene, leading to progressive cerebellar ataxia with symptoms like unsteady gait, tremors, and speech difficulties.
How is SCA31 inherited?
SCA31 follows an autosomal dominant inheritance pattern, meaning a single mutated copy of the BEAN1 gene from one parent can cause the condition.
What are the common symptoms of SCA31?
Symptoms include unsteady gait, balance problems, tremors, difficulty with speech and swallowing, and loss of muscle coordination, often appearing in adulthood.
How is SCA31 diagnosed?
Diagnosis involves clinical evaluation and genetic testing, such as the NGS Genetic Test, to detect BEAN1 gene mutations.
What does the NGS Genetic Test for SCA31 involve?
The test uses Next-Generation Sequencing to analyze the BEAN1 gene for mutations from a blood or DNA sample.
What is the cost of the BEAN1 Gene NGS Test in India?
The test costs INR 20,000, with free home sample collection available across many cities.
Is genetic testing for SCA31 covered by insurance?
Often, genetic testing is covered by health insurance plans; it is advisable to check with your provider for specific coverage details.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What should I do before getting tested?
Undergo genetic counselling to understand the test implications and provide a detailed family history.
Can the test detect all SCA31 mutations?
The NGS test is highly sensitive but may not detect all possible variants; interpretation by a geneticist is essential.
What are the risks of genetic testing?
Risks include psychological stress from positive results and potential incidental findings; counselling is recommended.
How can I book this test?
Book online through DNA Labs India for free home sample collection or visit a walk-in center. Contact for more details.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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