Biopsy Breast (Modified Radical Mastectomy+ER+PR) Test
Short Name: Breast Biopsy MRM+ER/PR
Also known as: Breast Biopsy with ER/PR, MRM Biopsy ER PR, Modified Radical Mastectomy Biopsy
Biopsy Breast (Modified Radical Mastectomy+ER+PR) Test test available at DNA Labs India for ₹6,750. Uses Histopathology, Immunohistochemistry (IHC) for ER/PR on Tissue (Breast biopsy specimen) samples. Results in Reports are typically available within 6 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm the presence of breast cancer, evaluate the histological characteristics of the tumor, and determine the expression of estrogen and progesterone receptors. This information is essential for staging, prognosis, and selecting appropriate targeted therapies. ER/PR positive tumors are likely to respond to endocrine therapy, while negative tumors may require alternative treatments. The test also helps in assessing the completeness of surgical resection and guiding adjuvant therapy decisions.
- Test Code
- 6060
- CPT Code
- 88305, 88360
- ICD Code
- C50.9
- Price
- ₹6,750
- Sample Type
- Tissue (Breast biopsy specimen)
- Result Time
- Reports are typically available within 6 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Histopathology, Immunohistochemistry (IHC) for ER/PR
Sample Collection
No special preparation required. A doctor's prescription is necessary. Inform your doctor about any medications or supplements you are taking.
Method: Surgical biopsy / Excision
Laboratory Analysis
The biopsy procedure is performed by a surgeon. Tissue sample is collected and placed in a container with 10% neutral buffered formalin.
Report Delivery
The sample is sent to the laboratory for processing. You may experience mild discomfort at the biopsy site; follow your doctor's post-operative instructions.
Timeline: Reports are typically available within 6 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm the presence of breast cancer, evaluate the histological characteristics of the tumor, and determine the expression of estrogen and progesterone receptors. This information is essential for staging, prognosis, and selecting appropriate targeted therapies. ER/PR positive tumors are likely to respond to endocrine therapy, while negative tumors may require alternative treatments. The test also helps in assessing the completeness of surgical resection and guiding adjuvant therapy decisions.
How to Prepare
- Tissue must be placed in 10% Neutral Buffered Formalin immediately after collection
- Use a sterile, leak-proof container
- Label the container with patient details and site of biopsy
- Transport at ambient temperature to the laboratory within 24 hours
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"ER/PR testing is essential for guiding hormonal therapy in breast cancer. Accurate histopathology ensures optimal treatment decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not in formalin
- Inadequate tissue volume
- Sample leaked or unlabeled
- Sample received after prolonged delay without proper preservation
Understanding Your Results
ER Positive, PR Positive
Tumor likely to respond to hormonal therapy (e.g., tamoxifen, aromatase inhibitors).
ER Positive, PR Negative
Partial response to hormonal therapy possible; other factors considered.
ER Negative, PR Negative
Hormonal therapy unlikely to be effective; chemotherapy may be considered.
Malignant cells present
Confirms breast cancer; further grading and staging required.
No malignant cells detected
No cancer identified in the sample; clinical correlation advised.
Consult your oncologist if you experience any breast symptoms or if you have been advised this test. Discuss your results with your doctor to understand the implications for your treatment plan.
Limitations
- ⚠Test is performed on tissue sample; false negatives possible if sample is not representative
- ⚠ER/PR status may change over time or after treatment
- ⚠Interpretation is subjective and depends on pathologist expertise
- ⚠Not a screening test; requires clinical correlation
Risks & Considerations
- ●Bleeding or hematoma at biopsy site
- ●Infection
- ●Pain or discomfort
- ●Scarring
- ●Rare risk of pneumothorax (if biopsy near chest wall)
Interfering Factors
- ●Improper tissue fixation may affect IHC results
- ●Decalcification of tissue can alter antigenicity
- ●Delayed processing may lead to tissue degradation
- ●Prior chemotherapy or radiation may affect receptor expression
Compare With Similar Tests
| Test | Biopsy Breast (Modified Radical Mastectomy+ER+PR) | Core Needle Biopsy | Fine Needle Aspiration (FNA) | Excisional Biopsy |
|---|---|---|---|---|
| Comparison | Biopsy Breast (Modified Radical Mastectomy+ER+PR) |
Frequently Asked Questions
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