Biopsy Electron Microscopy Test
Short Name: Biopsy EM
Also known as: EM Biopsy, Electron Microscopy of Tissue, Ultrastructural Examination
Biopsy Electron Microscopy Test test available at DNA Labs India for ₹12,000. Uses Electron Microscopy (EM) on Tissue samples. Results in Reports are available within 21 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of Biopsy Electron Microscopy is to identify structural abnormalities at the cellular and subcellular level that cannot be detected by routine light microscopy. It is particularly useful in diagnosing conditions such as glomerular diseases, metabolic disorders, certain infections, and tumors. The detailed ultrastructural analysis aids in differentiating between similar-looking lesions, determining the origin of tumors, and assessing the effectiveness of treatments. By providing high-resolution images, electron microscopy enables pathologists to make more accurate diagnoses, which is crucial for selecting the most appropriate therapeutic approach.
- Test Code
- 6059
- CPT Code
- 88348
- ICD Code
- Z00.6
- Price
- ₹12,000
- Sample Type
- Tissue
- Result Time
- Reports are available within 21 days after sample collection.
- Fasting Required
- No
- Method
- Electron Microscopy (EM)
Sample Collection
No special preparation is required. However, a doctor's prescription is necessary. Inform your doctor about any medications you are taking.
Method: Biopsy procedure
Laboratory Analysis
The tissue sample is collected via a biopsy procedure, which may involve local anesthesia. The sample is then placed in a fixative solution (2% Glutaraldehyde) for transport.
Report Delivery
You may resume normal activities immediately after the biopsy. The sample will be sent to the laboratory for processing. Results are typically available within 21 days.
Timeline: Reports are available within 21 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of Biopsy Electron Microscopy is to identify structural abnormalities at the cellular and subcellular level that cannot be detected by routine light microscopy. It is particularly useful in diagnosing conditions such as glomerular diseases, metabolic disorders, certain infections, and tumors. The detailed ultrastructural analysis aids in differentiating between similar-looking lesions, determining the origin of tumors, and assessing the effectiveness of treatments. By providing high-resolution images, electron microscopy enables pathologists to make more accurate diagnoses, which is crucial for selecting the most appropriate therapeutic approach.
How to Prepare
- Tissue sample must be placed in 2% Glutaraldehyde (CIDEX) immediately after collection.
- The sample should be transported to the laboratory at ambient temperature.
- Ensure the sample container is properly labeled with patient details.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Electron microscopy provides critical ultrastructural details that guide precise diagnosis and targeted therapy in complex oncologic and renal cases."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not in appropriate fixative
- Sample leaked or damaged during transport
- Inadequate tissue sample
- Sample not labeled correctly
Understanding Your Results
Normal ultrastructure
No significant cellular abnormalities detected
Mitochondrial abnormalities
May indicate mitochondrial disorders or metabolic diseases
Viral inclusion bodies
Suggests viral infection
Abnormal nuclear morphology
May indicate malignancy or dysplastic changes
Deposits in glomerular basement membrane
Suggests glomerulonephritis or immune complex deposition
If you are experiencing symptoms such as unexplained weight loss, chronic fatigue, or persistent pain, or if your doctor suspects a condition that requires electron microscopy, consult a healthcare professional for further evaluation.
Limitations
- ⚠Requires specialized equipment and expertise
- ⚠Not available at all diagnostic centers
- ⚠May not be conclusive for all conditions
- ⚠Longer turnaround time compared to routine histopathology
Risks & Considerations
- ●Minor bleeding or infection at biopsy site
- ●Allergic reaction to local anesthesia (rare)
Interfering Factors
- ●Improper tissue fixation
- ●Delay in sample processing
- ●Inadequate sample size
- ●Contamination during collection
Compare With Similar Tests
| Test | Biopsy Electron Microscopy | Routine Histopathology | Immunohistochemistry |
|---|---|---|---|
| Comparison | Biopsy Electron Microscopy | Uses light microscopy, lower resolution, faster turnaround, less expensive | Detects specific proteins, complementary to EM, but does not provide ultrastructural details |
Frequently Asked Questions
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