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Immunohistochemistry 34-Beta E12 / HMW-CK Test

DNA Labs India | ISO 9001:2015 Certified

Immunohistochemistry 34-Beta E12 / HMW-CK Test

Short Name: 34-Beta E12 / HMW-CK IHC Test

Also known as: High Molecular Weight Cytokeratin Test, 34BE12 IHC

Immunohistochemistry 34-Beta E12 / HMW-CK Test test available at DNA Labs India for ₹3,500. Uses Immunohistochemistry on Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded tissue block samples. Results in Reports available within 5-7 days.. Free home collection in 300+ cities across India.

Immunohistochemistry🏠 Home Collection

🩺 Medically Reviewed By

Overview

To detect the presence of high molecular weight cytokeratins in tissues for cancer diagnosis, particularly useful in differentiating benign and malignant prostatic lesions.

Test Code
909
Price
₹3,500
Sample Type
Tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded tissue block
Result Time
Reports available within 5-7 days.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Provide a copy of the Histopathology Report, site of biopsy, and clinical history.

Method: Tissue biopsy collection

Step 2

Laboratory Analysis

Tissue sample collected via biopsy by a healthcare professional.

Step 3

Report Delivery

Sample preserved in formalin and sent to the laboratory.

Timeline: Reports available within 5-7 days.

Patient Instructions

1
Before the Test:Provide clinical history and previous reports.
2
During the Test:Tissue sample is processed and stained for immunohistochemical analysis.
3
After the Test:Results are reviewed by a pathologist and reported.

About This Test

Who Should Get This Test

To detect the presence of high molecular weight cytokeratins in tissues for cancer diagnosis, particularly useful in differentiating benign and malignant prostatic lesions.

How to Prepare

  • Submit tumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded tissue block
  • Provide a copy of the Histopathology Report
  • Specify site of biopsy and clinical history

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is crucial for confirming prostate cancer by detecting basal cell loss, aiding in accurate diagnosis and treatment planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor tissue in 10% Formal-saline or Formalin fixed paraffin embedded tissue block
Sample VolumeAs per tissue block
Container10% Formal-saline or Formalin fixed paraffin embedded tissue block
Collection MethodTissue biopsy collection

Sample Stability

Stable at room temperature when properly fixed
Sample Rejection Criteria:
  • Inadequate fixation
  • Insufficient tissue
  • Missing clinical information

Understanding Your Results

Results indicate the presence or absence of high molecular weight cytokeratins, helping to distinguish between benign and malignant conditions.
Positive staining: Suggestive of benign prostatic glands or normal tissue
Loss of staining: Indicative of prostate cancer, as basal cells are absent
Interpretation should correlate with histopathology and clinical findings
⚠️ When to Consult a Doctor:

If symptoms persist or if abnormal results are obtained, consult an oncologist or pathologist for further evaluation.

Limitations

  • Not specific for all cancer types
  • Requires adequate tissue sample
  • Interpretation dependent on pathologist expertise

Risks & Considerations

  • Standard biopsy risks such as infection or bleeding
  • No direct risks from the test itself

Interfering Factors

  • Poor tissue fixation
  • Inadequate tissue sample
  • Technical errors in staining

Frequently Asked Questions

What is the Immunohistochemistry 34-Beta E12 / HMW-CK test?
It is a diagnostic test that uses antibodies to detect high molecular weight cytokeratins in tissue samples, primarily for cancer diagnosis.
Why is this test performed?
To help diagnose and differentiate cancers, especially prostate cancer, by identifying basal cell loss in tissues.
What is the cost of the test?
The test costs INR 3500 at DNA Labs India, with free home sample collection available across India.
What sample is required for the test?
A tumor tissue sample fixed in formalin or as a paraffin-embedded block, along with histopathology report and clinical history.
How is the test performed?
The tissue sample is processed, stained with antibodies, and examined under a microscope by a pathologist.
What cancers can this test diagnose?
It is commonly used for prostate cancer and may assist in diagnosing breast, lung, bladder, colon, and stomach cancers.
How long does it take to get results?
Results are typically available within 5 to 7 days after sample receipt.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What are the risks associated with the test?
Risks are primarily related to the biopsy procedure, such as infection or bleeding; the test itself has no direct risks.
How should I prepare for the test?
Provide a copy of the histopathology report, site of biopsy, and clinical history as pre-test information.
What does a positive or negative result mean?
Positive staining may indicate benign tissue, while loss of staining suggests malignancy; interpretation should be done by a pathologist.
Is this test covered by insurance?
Coverage depends on the insurance scheme; it is not universally covered, so check with your provider.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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