CALR Gene Schizophrenia, CALR related NGS Genetic Test
Short Name: CALR Schizophrenia NGS
Also known as: Calreticulin Gene Schizophrenia Test, CALR NGS Genetic Test, CALR Mutation Analysis for Schizophrenia Risk
CALR Gene Schizophrenia, CALR related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect sequence variants in the CALR gene that have been reported in association with schizophrenia susceptibility. It helps clinicians evaluate a possible inherited component in individuals with a clinical or family history of schizophrenia. The test should be used together with psychiatric assessment, neurological evaluation, and genetic counseling.
- Test Code
- 4494
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. The treating physician will document the clinical history and arrange a genetic counseling session to draw a three-generation pedigree before sample collection.
Method: Venipuncture or FTA card blood spot
Laboratory Analysis
A peripheral blood sample is collected by a trained phlebotomist. Alternatively, extracted DNA or one drop of blood on an FTA card can be submitted as per laboratory instructions.
Report Delivery
You can resume normal activities immediately after sample collection. The report will be delivered within 3 to 4 weeks after the laboratory receives the sample.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect sequence variants in the CALR gene that have been reported in association with schizophrenia susceptibility. It helps clinicians evaluate a possible inherited component in individuals with a clinical or family history of schizophrenia. The test should be used together with psychiatric assessment, neurological evaluation, and genetic counseling.
How to Prepare
- No fasting required.
- Complete clinical history and pedigree chart must be submitted with the test.
- EDTA whole blood is preferred for blood collection.
- For FTA card sample, one drop of blood is sufficient.
- The sample must be labeled with patient name, date of birth, and collection date.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"CALR gene sequencing may inform risk assessment, but a diagnosis of schizophrenia should always be made by a psychiatrist or neurologist using validated clinical criteria."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Unlabelled or mislabelled sample
- Hemolyzed or clotted blood sample
- Sample received without completed clinical history or pedigree
- Expired or incorrect collection tube
Understanding Your Results
The individual carries a CALR variant that has been associated with increased schizophrenia risk. Results should be integrated with clinical findings and family history. Genetic counseling is strongly recommended.
The variant is highly probable to be disease-associated. Additional family segregation studies may help clarify its role.
Clinical significance is currently unknown. Testing first-degree relatives may help determine whether the variant segregates with the condition.
A negative result reduces the likelihood of a CALR-mediated schizophrenia risk but does not exclude schizophrenia or other genetic causes.
Consult a psychiatrist or neurologist if you or a family member experience hallucinations, delusions, social withdrawal, or a noticeable decline in daily functioning. A positive genetic result also warrants consultation for personalized risk assessment and counseling.
Limitations
- ⚠This test analyses only the CALR gene; other genes involved in schizophrenia are not covered.
- ⚠Large genomic rearrangements and deep intronic variants may not be detected by standard NGS.
- ⚠A negative result does not exclude schizophrenia or a genetic cause.
- ⚠A positive result does not confirm the diagnosis of schizophrenia.
- ⚠Variants of uncertain significance may be reported and may require additional family testing.
Risks & Considerations
- ●Mild bruising or discomfort at the venipuncture site
- ●Psychological anxiety from uncertain genetic results
- ●Possible incidental findings unrelated to the reason for testing
Interfering Factors
- ●Poor DNA quality or quantity may reduce sequencing accuracy.
- ●Contamination from another person's DNA can lead to incorrect results.
- ●Incomplete or inaccurate clinical and family history may affect interpretation.
- ●Somatic CALR variants associated with haematological disorders should not be interpreted as germline schizophrenia-risk variants.
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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