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CASP10 Gene Autoimmune lymphoproliferative syndrome type 2A NGS Genetic Test

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CASP10 Gene Autoimmune lymphoproliferative syndrome type 2A NGS Genetic Test

Short Name: CASP10 Gene ALPS Type 2A NGS Test

Also known as: Autoimmune Lymphoproliferative Syndrome Type 2A, ALPS Type 2A

CASP10 Gene Autoimmune lymphoproliferative syndrome type 2A NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations in the CASP10 gene for definitive diagnosis of autoimmune lymphoproliferative syndrome type 2A, aiding in personalized treatment and management.

Test Code
2372
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session to discuss test implications, clinical history review, and informed consent.

Method: Blood draw or FTA Card

Step 2

Laboratory Analysis

Blood sample drawn by a trained phlebotomist or use of FTA card with one drop of blood.

Step 3

Report Delivery

Sample labeled correctly and sent to the lab for NGS analysis; results reviewed by a geneticist.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consultation with a genetic counselor, review of clinical and family history, and informed consent.
2
During the Test:Blood sample collection via venipuncture or FTA card.
3
After the Test:Results analyzed and reported by the lab; follow-up with a healthcare provider for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the CASP10 gene for definitive diagnosis of autoimmune lymphoproliferative syndrome type 2A, aiding in personalized treatment and management.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Follow standard blood draw procedures
  • For FTA card, apply one drop of blood and air dry

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or FTA Card

Sample Stability

Blood sample stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or contaminated sample
  • Incorrect labeling or missing information

Understanding Your Results

Genetic testing for CASP10 gene mutations can confirm a diagnosis of ALPS type 2A. Results should be correlated with clinical symptoms and family history.
📊

Confirms diagnosis of ALPS type 2A; recommend genetic counseling and personalized treatment plan.

📊

ALPS type 2A is unlikely based on this gene; consider other genetic causes or clinical reevaluation.

⚠️ When to Consult a Doctor:

If you experience symptoms of ALPS such as enlarged lymph nodes, autoimmune issues, or recurrent infections, or if there is a family history of similar conditions.

Limitations

  • ⚠May not detect all genetic variants or mutations in other genes
  • ⚠Results require interpretation by a qualified geneticist
  • ⚠Does not replace comprehensive clinical evaluation

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Potential psychological impact of genetic results
  • ●Possible need for further testing

Interfering Factors

  • ●Poor sample quality or DNA degradation
  • ●Contamination during sample collection
  • ●Inadequate clinical history provided

Compare With Similar Tests

TestCASP10 Gene Autoimmune lymphoproliferative syndrome type 2A NGS Genetic TestALPS Panel (Multiple Genes)FAS Gene Test
ComparisonCASP10 Gene Autoimmune lymphoproliferative syndrome type 2A NGS Genetic Test

Frequently Asked Questions

What is the CASP10 Gene Autoimmune Lymphoproliferative Syndrome Type 2A NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to identify mutations in the CASP10 gene, which is associated with ALPS type 2A, a rare immune disorder.
Who should consider this test?
Individuals with symptoms of ALPS, such as enlarged lymph nodes or autoimmune disorders, or those with a family history of ALPS type 2A.
How is the test performed?
A blood sample or DNA extract is analyzed using NGS technology to sequence the CASP10 gene and detect mutations.
What are the symptoms of ALPS type 2A?
Common symptoms include enlarged lymph nodes, liver, spleen, autoimmune hemolytic anemia, thrombocytopenia, neutropenia, recurrent infections, and increased lymphoma risk.
What is the cost of the test?
The test costs INR 20,000, which includes home sample collection and genetic counseling.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for this test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the CASP10 gene, confirming diagnosis of ALPS type 2A, which guides personalized treatment.
What if the test is negative?
A negative result makes ALPS type 2A unlikely based on this gene; other causes may be explored with further testing.
Is genetic counseling included?
Yes, a genetic counseling session is part of the service to discuss test implications and family history.
Can this test be used for prenatal diagnosis?
This test is primarily for diagnostic purposes; prenatal testing should be discussed with a genetic counselor.
Is the test covered by insurance?
Coverage depends on insurance policies; it is not typically covered under government schemes, but check with your provider.
What follow-up is recommended after a positive result?
After a positive result, regular monitoring by a healthcare provider, genetic counseling for family members, and possibly starting treatment to manage symptoms and prevent complications are recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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