CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia NGS Genetic Test
Short Name: CCT5 NGS Genetic Test
Also known as: CCT5 Gene Mutation Analysis, Hereditary Sensory Neuropathy with Spastic Paraplegia Genetic Test, CCT5 Sequencing, CCT5 Gene Panel
CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The final report is delivered within 3 to 4 weeks from the date of sample receipt. The laboratory may take additional time if repeated testing or variant confirmation is required.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the CCT5 gene NGS genetic test is to detect pathogenic variants in the CCT5 gene associated with hereditary sensory neuropathy with spastic paraplegia. It serves to confirm a clinical diagnosis, differentiate it from other inherited neuropathies, guide genetic counselling, and inform family members about their recurrence risk. This test is not intended for prenatal diagnosis or predictive testing in asymptomatic minors unless clinically indicated.
- Test Code
- 4426
- ICD Code
- G60.8
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The final report is delivered within 3 to 4 weeks from the date of sample receipt. The laboratory may take additional time if repeated testing or variant confirmation is required.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
Clinical History of Patient who is going for CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia Disease.
Method: Venipuncture or FTA card spot
Laboratory Analysis
No special precautions are required. Blood sample collection is a routine procedure. If using FTA card, a single drop of blood is applied to the card and allowed to dry.
Report Delivery
The sample is securely transported to the laboratory. Results will be shared after 3 to 4 weeks along with a detailed interpretation report.
Timeline: The final report is delivered within 3 to 4 weeks from the date of sample receipt. The laboratory may take additional time if repeated testing or variant confirmation is required.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the CCT5 gene NGS genetic test is to detect pathogenic variants in the CCT5 gene associated with hereditary sensory neuropathy with spastic paraplegia. It serves to confirm a clinical diagnosis, differentiate it from other inherited neuropathies, guide genetic counselling, and inform family members about their recurrence risk. This test is not intended for prenatal diagnosis or predictive testing in asymptomatic minors unless clinically indicated.
How to Prepare
- No fasting is required.
- Use an EDTA vacutainer for blood sample.
- If using FTA card, place a single drop of blood in the marked circle and let it air dry for at least 1 hour.
- Label the sample with patient name and date of collection.
- Avoid hemolysis and clot formation.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing plays a crucial role in confirming the diagnosis of hereditary neuropathies and enabling accurate recurrence risk counselling for families."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Incorrectly labeled sample
- Sample collected in non-EDTA tube
- Sample exposed to extreme temperatures
- Insufficient quantity of blood or inadequate DNA yield
Understanding Your Results
Pathogenic variant detected
The patient has a confirmed genetic cause for CCT5 gene neuropathy. Genetic counselling is recommended.
Variant of uncertain significance (VUS)
A genetic variant was found, but its pathogenicity is unknown. Additional family studies may be required.
No pathogenic variant detected
No disease-causing change was identified in the CCT5 gene. Alternative diagnoses should be considered.
If you are experiencing symptoms such as sensory loss, spasticity, or difficulty walking, or if you have a family history of hereditary sensory neuropathy or spastic paraplegia, consult a neurologist or geneticist to discuss the suitability of this genetic test.
Limitations
- ⚠This test only analyzes the CCT5 gene and cannot rule out variants in other genes associated with similar phenotypes.
- ⚠It may not detect all types of mutations, such as large structural rearrangements not identified by standard NGS.
- ⚠Results should be interpreted in the context of clinical findings and family history.
- ⚠Variant classification may be revised as new scientific evidence emerges.
Risks & Considerations
- ●No major physical risks associated with blood sampling.
- ●Possible mild bruising or discomfort at the venipuncture site.
- ●Psychological implications of discovering a genetic condition in the family.
Interfering Factors
- ●Contamination of the sample with DNA from other sources
- ●Very low DNA quantity or quality
- ●Presence of maternal cell contamination in fetal samples (not applicable for this test)
- ●Sequence variants in regions not covered by the assay
Compare With Similar Tests
| Test | CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia NGS Genetic Test | CCT5 Gene NGS Test | Hereditary Neuropathy Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | CCT5 Gene Neuropathy, hereditary sensory, with spastic paraplegia NGS Genetic Test |
Frequently Asked Questions
What is the cost of the CCT5 gene neuropathy NGS genetic test in India?
What sample is required for this test?
Do I need to fast before the blood sample is taken?
How long does it take to get the results?
What does the CCT5 gene test detect?
Is this test suitable for affected children?
Can this test be done on a sample from someone outside India?
What does a negative test result mean?
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Will the test affect my health insurance?
Is genetic counselling included in the test price?
Which cities in India offer free home sample collection?
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