Skip to main content
DNA Labs India

CHGB Gene Amyotrophic Lateral Sclerosis Risk Factor NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CHGB Gene Amyotrophic Lateral Sclerosis Risk Factor NGS Genetic Test

Short Name: CHGB ALS Risk Factor NGS Test

Also known as: CHGB Gene Mutation Test, Chromogranin B Gene ALS Risk Test, ALS Risk Factor Genetic Test, CHGB NGS Sequencing

CHGB Gene Amyotrophic Lateral Sclerosis Risk Factor NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks after sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to evaluate the CHGB gene for sequence variants that may be associated with an increased risk of amyotrophic lateral sclerosis. It is intended to support clinicians in risk assessment and family counselling when used alongside established ALS genetic tests.

Test Code
3875
CPT Code
N/A
ICD Code
G12.21
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks after sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

A genetic counselling session is recommended to explain the purpose, limitations, and possible outcomes of the test. A three-generation pedigree should be drawn to document family members affected by ALS or neurological disorders.

Method: Peripheral blood draw or FTA card blood spot

Step 2

Laboratory Analysis

A trained professional will collect a small amount of blood in an EDTA tube. If FTA card sampling is used, one drop of blood is applied to the card and allowed to dry.

Step 3

Report Delivery

There are no restrictions after sample collection. You can resume normal activities while the sample is transported to the laboratory for DNA extraction and NGS analysis.

Timeline: 3 to 4 weeks after sample reaches the laboratory.

Patient Instructions

1
Before the Test:Before the test, a genetic counselling session is recommended to assess family history, explain the limitations, and decide whether targeted CHGB testing is clinically appropriate.
2
During the Test:The test involves only a simple blood collection or FTA card sample; no special preparation is required.
3
After the Test:After sample submission, the laboratory processes the sample and prepares a detailed NGS-based report. You will be notified when the report is ready.

About This Test

Who Should Get This Test

The purpose of this test is to evaluate the CHGB gene for sequence variants that may be associated with an increased risk of amyotrophic lateral sclerosis. It is intended to support clinicians in risk assessment and family counselling when used alongside established ALS genetic tests.

How to Prepare

  • No fasting is required
  • Inform the lab if you have any bleeding disorders or are on anticoagulants
  • FTA card must be labelled and air-dried before packaging
  • Sample should be transported to the laboratory within the recommended time

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"CHGB gene results must never be used in isolation. A neurologist will correlate them with neurological examination, EMG/NCS findings, and family history. The presence of a CHGB variant does not establish an ALS diagnosis, and its absence does not rule out ALS or genetic susceptibility."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory requirement
ContainerEDTA vacutainer / sterile DNA tube / FTA card
Collection MethodPeripheral blood draw or FTA card blood spot

Sample Stability

Whole blood in EDTA: 48 hours at 2-8°C
FTA card: stable for several weeks at room temperature
Extracted DNA: short-term at 2-8°C, long-term at -20°C
Avoid repeated freeze-thaw cycles
Sample Rejection Criteria:
  • Clotted or haemolysed blood sample
  • Insufficient sample volume
  • Improperly labelled sample
  • Contaminated or improperly dried FTA card
  • Sample received after prolonged storage outside recommended conditions

Understanding Your Results

The result should be interpreted in the context of the patient’s full neurological evaluation, family history, and other relevant laboratory findings.
📊

No clinically significant CHGB variant was detected. This does not exclude ALS risk, as other genetic, environmental, and non-genetic factors may be involved.

📊

The clinical significance of the variant is currently unknown. Additional family segregation studies, functional evidence, and updated variant databases may be needed.

📊

A risk-associated variant has been identified. For CHGB, the evidence supporting ALS risk is not firmly established. A clinical geneticist and neurologist should discuss the implications and possible next steps.

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist if you have symptoms suggestive of ALS, a family history of ALS, or if your result shows a variant of uncertain significance.

Limitations

  • ⚠CHGB is not a major confirmed ALS gene; only limited research evidence exists
  • ⚠This test is not a substitute for a comprehensive ALS genetic panel
  • ⚠Absence of a CHGB variant does not exclude ALS or non-genetic causes
  • ⚠Variant interpretation may change over time as new scientific evidence emerges
  • ⚠This test does not detect large copy number changes or repeat expansions in other genes

Risks & Considerations

  • ●Minimal pain or bruising at the blood collection site
  • ●Psychological stress related to potential risk information
  • ●Variant of uncertain significance may cause anxiety
  • ●Privacy or confidentiality concerns related to genetic information

Interfering Factors

  • ●Presence of other ALS-associated genetic variants may confound interpretation
  • ●Low DNA quality or quantity can affect sequencing accuracy
  • ●Variants in deeply intronic or regulatory regions not covered by this targeted test
  • ●Low-level somatic mosaicism may not be detected
  • ●Sample contamination during FTA card handling

Compare With Similar Tests

TestCHGB Gene Amyotrophic Lateral Sclerosis Risk Factor NGS Genetic Test
ComparisonCHGB Gene Amyotrophic Lateral Sclerosis Risk Factor NGS Genetic Test

Frequently Asked Questions

What is the CHGB gene ALS risk factor NGS genetic test?
It is a targeted next-generation sequencing test that analyses the CHGB gene for sequence variants that may contribute to ALS risk. It is not a diagnostic test for ALS.
Is CHGB a confirmed ALS gene?
No, CHGB is not yet a confirmed or major ALS gene. Some studies have suggested it may play a modifying role, but the evidence is limited. Established ALS genes should be tested first unless otherwise advised.
What is the cost of this genetic test at DNA Labs India?
The test costs Rs 20,000, including free home sample collection in eligible cities.
What sample is required for the CHGB gene NGS test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required for this test?
No, fasting is not required.
How long does it take to receive results?
The report is generally ready in 3 to 4 weeks.
Can this test diagnose ALS?
No. This test cannot confirm ALS and should not be used alone to diagnose or predict ALS.
Who should consider taking this test?
It may be considered by people with a family history of ALS or by individuals with ALS who have negative results in established ALS genes, after proper genetic counselling.
What does a positive result mean?
A pathogenic or likely pathogenic variant in CHGB may indicate increased risk; however, because CHGB's link to ALS is not well established, the clinical implications must be explained by a clinical geneticist or neurologist.
Does this test cover all ALS-related genes?
No. This test only analyses the CHGB gene. Other genes like SOD1, C9orf72, TARDBP and FUS are not included.
Is home sample collection available for this test?
Yes, free home sample collection is available for online bookings at DNA Labs India across many cities in India.
Will I get genetic counselling with this test?
A pre-test genetic counselling session to draw a family pedigree is recommended, and post-test counselling is advised if clinically indicated.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.