Chimerism Pre-Engraftment Donor & Recipient Test
Short Name: Chimerism Pre-Engraftment Test
Also known as: Chimerism Analysis, HSCT Engraftment Test, Donor-Recipient Chimerism Test
Chimerism Pre-Engraftment Donor & Recipient Test test available at DNA Labs India for ₹13,000. Uses PCR, STR / Fragment analysis on Whole blood from Donor and Recipient samples. Results in 10-12 days from sample collection. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the Chimerism Pre-Engraftment Donor & Recipient Test is to determine the level of engraftment between donor and recipient cells after allogeneic hematopoietic stem cell transplantation (HSCT). It aids in detecting symptoms such as rejection of donor cells, failure of engraftment, and relapse of the underlying disease, enabling early intervention to improve transplant success.
- Test Code
- 292
- Price
- ₹13,000
- Sample Type
- Whole blood from Donor and Recipient
- Result Time
- 10-12 days from sample collection
- Fasting Required
- No
- Method
- PCR, STR / Fragment analysis
Sample Collection
No special preparation required
Method: Venipuncture
Laboratory Analysis
Standard venipuncture procedure; collect 4 ml whole blood in EDTA tubes from both donor and recipient
Report Delivery
Apply pressure to puncture site; label tubes appropriately as Donor and Recipient
Timeline: 10-12 days from sample collection
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Chimerism Pre-Engraftment Donor & Recipient Test is to determine the level of engraftment between donor and recipient cells after allogeneic hematopoietic stem cell transplantation (HSCT). It aids in detecting symptoms such as rejection of donor cells, failure of engraftment, and relapse of the underlying disease, enabling early intervention to improve transplant success.
How to Prepare
- Label tubes clearly as Donor and Recipient
- Store samples at refrigerated temperature (2-8°C)
- Do not freeze samples
- Ship within 72 hours of collection
- Use appropriate packaging to prevent leakage
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for monitoring engraftment post-HSCT to ensure treatment success and early detection of complications such as graft rejection or relapse."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed samples
- Incorrect or missing labeling
- Insufficient sample volume
- Samples stored at room temperature for prolonged periods
- Frozen samples
Understanding Your Results
High donor chimerism (>95%)
Indicates successful engraftment; monitor for stability
Mixed chimerism (5-95%)
May require close monitoring or intervention depending on clinical context
Low donor chimerism (<5%)
Suggests graft rejection or failure; consult hematologist immediately
Consult your doctor if results show low donor chimerism, signs of graft rejection, disease relapse, or if you experience symptoms like fever, fatigue, or infection post-transplant.
Limitations
- ⚠Cannot detect all types of chimerism, such as cryptic chimerism
- ⚠Depends on informative genetic markers between donor and recipient
- ⚠May require repeat testing for accurate monitoring
- ⚠Does not provide information on cell function or viability
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or discomfort at puncture site
- ●Rare risk of infection or hematoma
Interfering Factors
- ●Hemolyzed blood samples
- ●Improper sample storage or handling
- ●Recent blood transfusions may affect results
- ●Contamination during sample collection
Compare With Similar Tests
| Test | Chimerism Pre-Engraftment Donor & Recipient Test | |||
|---|---|---|---|---|
| Comparison | Chimerism Pre-Engraftment Donor & Recipient Test | Flow cytometry measures cell surface markers; PCR-based chimerism is more sensitive for genetic differences | HLA typing is for donor matching pre-transplant; chimerism testing monitors post-transplant engraftment | Biopsy provides tissue-level analysis; chimerism test is less invasive using blood samples |
Frequently Asked Questions
What is the Chimerism Pre-Engraftment Donor & Recipient Test?
Why is this test performed after HSCT?
How is the chimerism test conducted?
What sample is required for this test?
What does a high donor chimerism percentage indicate?
What does a low donor chimerism percentage mean?
How long does it take to get results?
Is fasting required for this test?
Can this test be done at home?
What is the cost of the chimerism test?
How accurate is the chimerism pre-engraftment test?
Who should perform this test?
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