Chimerism Split Cell Analysis - T Cell (CD3) Test
Short Name: T Cell CD3 Chimerism Test
Also known as: Chimerism Split Cell Analysis, T Cell CD3 Test, Post-Transplant Chimerism Test
Chimerism Split Cell Analysis - T Cell (CD3) Test test available at DNA Labs India for ₹10,500. Uses Polymerase Chain Reaction (PCR), Short Tandem Repeat (STR) Analysis, Fragment Analysis on Whole blood or Bone marrow samples. Results in Report available in 7 working days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To monitor the success of bone marrow or stem cell transplantation by determining the percentage of donor-derived T cells (CD3 positive) in the recipient's blood or bone marrow, aiding in the assessment of engraftment, graft rejection, and immune reconstitution.
- Test Code
- 296
- Price
- ₹10,500
- Sample Type
- Whole blood or Bone marrow
- Result Time
- Report available in 7 working days after sample receipt.
- Fasting Required
- No
- Method
- Polymerase Chain Reaction (PCR), Short Tandem Repeat (STR) Analysis, Fragment Analysis
Sample Collection
Indicate the date of bone marrow transplant on the test requisition form. No special preparation is required otherwise.
Method: Venipuncture for whole blood; Bone marrow aspiration for bone marrow sample
Laboratory Analysis
For whole blood, standard venipuncture procedure is performed. For bone marrow, aspiration from the posterior iliac crest is done under local anesthesia.
Report Delivery
Ship the sample refrigerated immediately. Do not freeze the sample.
Timeline: Report available in 7 working days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To monitor the success of bone marrow or stem cell transplantation by determining the percentage of donor-derived T cells (CD3 positive) in the recipient's blood or bone marrow, aiding in the assessment of engraftment, graft rejection, and immune reconstitution.
How to Prepare
- Indicate Date of Bone Marrow Transplant on the form
- Collect 4 ml (2 ml min.) whole blood or bone marrow in 1 Lavender Top (EDTA) tube
- Ship refrigerated
- DO NOT FREEZE the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for monitoring engraftment and detecting graft rejection in stem cell transplant recipients."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Frozen sample
- Incorrect tube type (non-EDTA)
- Insufficient sample volume
- Missing transplant date information
Understanding Your Results
Consult your hematologist or transplant physician if chimerism levels are low, or if you experience symptoms like fever, recurrent infections, bleeding, or signs of graft-versus-host disease post-transplant.
Limitations
- ⚠Does not distinguish between different T cell subsets
- ⚠Results may be affected by recent blood transfusions
- ⚠Requires accurate date of transplant for proper interpretation
- ⚠Cannot detect all types of chimerism (e.g., microchimerism)
Risks & Considerations
- ●Minimal risk from blood draw: bruising, pain, or infection at the puncture site
- ●For bone marrow aspiration: localized pain, bleeding, or infection, which are generally rare
Interfering Factors
- ●Recent blood transfusion
- ●Sample contamination
- ●Improper storage of sample
- ●Recent chemotherapy or immunosuppression
Compare With Similar Tests
| Test | Chimerism Split Cell Analysis - T Cell (CD3) Test | Chimerism Analysis - Myeloid (CD33) | Chimerism Analysis - Whole Blood | HLA Typing |
|---|---|---|---|---|
| Comparison | Chimerism Split Cell Analysis - T Cell (CD3) Test |
Frequently Asked Questions
What is the Chimerism Split Cell Analysis - T Cell (CD3) Test?
Why is this test recommended after a bone marrow transplant?
How is the sample collected for this test?
What does the test measure specifically?
What is considered a normal result for chimerism?
How long does it take to receive the test results?
Is the test covered by health insurance in India?
Are there any risks associated with the test?
Do I need to fast before the test?
How should I prepare for the test?
What does it mean if my chimerism levels are low?
How frequently should this test be done after a transplant?
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