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DNA Labs India

CLN6 Additional Family Members Test

DNA Labs India | ISO 9001:2015 Certified

CLN6 Additional Family Members Test

Short Name: CLN6 Family

Also known as: CLN6 Carrier Test, CLN6 Family Screening

CLN6 Additional Family Members Test test available at DNA Labs India for ₹14,000. Uses Sanger sequencing, Next-generation sequencing on Blood samples. Results in Results are typically available within 10-14 business days after sample receipt.. Free home collection in 300+ cities across India.

Molecular🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to determine whether additional family members carry the same CLN6 gene mutation identified in the index patient. It helps in carrier detection, presymptomatic diagnosis, and genetic counseling for at-risk relatives.

Test Code
6293
CPT Code
81405
ICD Code
Z13.89
Price
₹14,000
Sample Type
Blood
Result Time
Results are typically available within 10-14 business days after sample receipt.
Fasting Required
No
Method
Sanger sequencing, Next-generation sequencing
Step 1

Sample Collection

No special preparation required. Inform your doctor about any medications or supplements.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.

Step 3

Report Delivery

You may resume normal activities immediately. Apply pressure to the puncture site to prevent bruising.

Timeline: Results are typically available within 10-14 business days after sample receipt.

Patient Instructions

1
Before the Test:No special preparation. Ensure you have the index patient's genetic report for comparison.
2
During the Test:A simple blood draw is performed. The sample is sent to the lab for DNA extraction and sequencing.
3
After the Test:You will receive your report via email/portal. Genetic counseling is recommended to understand the implications.

About This Test

Who Should Get This Test

The purpose of this test is to determine whether additional family members carry the same CLN6 gene mutation identified in the index patient. It helps in carrier detection, presymptomatic diagnosis, and genetic counseling for at-risk relatives.

How to Prepare

  • No fasting required
  • Avoid alcohol for 24 hours prior
  • Stay hydrated
  • Bring previous genetic reports if available

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Testing additional family members for CLN6 is crucial for identifying carriers and providing genetic counseling to prevent recurrence in future pregnancies."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume2-3 mL
ContainerEDTA lavender top tube
Collection MethodVenipuncture

Sample Stability

Blood: 7 days at 2-8°C
Extracted DNA: 1 year at -20°C
Sample Rejection Criteria:
  • Hemolyzed sample
  • Clotted sample
  • Incorrect labeling
  • Sample received after 7 days without proper storage

Understanding Your Results

The test result will indicate whether a pathogenic variant in the CLN6 gene is present. A positive result confirms carrier or affected status, while a negative result reduces but does not eliminate the possibility of other genetic causes.
📊

Positive (heterozygous)

Carrier of CLN6 mutation; no disease symptoms expected but risk of passing to offspring.

📊

Positive (homozygous or compound heterozygous)

Affected with CLN6; clinical correlation required.

📊

Negative

No mutation detected in the CLN6 gene; residual risk remains for other NCL types.

⚠️ When to Consult a Doctor:

Consult a geneticist or neurologist if you have a family history of CLN6, if you are planning a pregnancy, or if you experience symptoms such as vision loss, seizures, or developmental regression.

Limitations

  • ⚠This test only analyzes the CLN6 gene; other NCL genes are not covered.
  • ⚠Variant of uncertain significance (VUS) may require further analysis.
  • ⚠Does not predict severity or age of onset.
  • ⚠Not intended for prenatal diagnosis without prior counseling.

Risks & Considerations

  • ●Minimal risk of bruising or infection at the puncture site
  • ●Psychological impact of learning carrier status
  • ●Potential for uncertain results (VUS)

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Recent blood transfusion (within 2 weeks)
  • ●Bone marrow transplantation
  • ●Mosaic mutations may be missed

Compare With Similar Tests

TestCLN6 Additional Family MembersCLN6 Single Gene TestNCL Panel (Multiple Genes)Whole Exome Sequencing
ComparisonCLN6 Additional Family Members

Frequently Asked Questions

What is CLN6 disease?
CLN6 disease is a rare inherited neurological disorder caused by mutations in the CLN6 gene, leading to progressive brain damage, vision loss, and seizures.
Who should get this test?
Any family member (parents, siblings, children) of a person diagnosed with CLN6 should consider testing to determine carrier status.
What is the cost of the test?
The test costs INR 14000, which includes home sample collection and genetic counseling.
Is fasting required?
No, fasting is not required for this test.
How is the sample collected?
A blood sample is collected from a vein in your arm. We offer free home collection across India.
How long does it take to get results?
Results are typically available within 10-14 business days after the sample reaches the lab.
What does a positive result mean?
A positive result means you carry a mutation in the CLN6 gene. If you have two mutations, you may be affected; if one, you are a carrier.
Can this test be done during pregnancy?
Yes, but prenatal testing requires additional procedures and should be discussed with a genetic counselor.
Is the test covered by insurance?
Most insurance plans do not cover genetic testing for family members; please check with your provider.
Are there any risks?
The blood draw carries minimal risks such as slight bruising or infection, which are rare.
What is the difference between this test and the single gene test?
This test is specifically for additional family members and is priced lower than the initial diagnostic test for the index patient.
Do I need a doctor's prescription?
While not mandatory, we recommend consulting a geneticist to ensure appropriate testing and interpretation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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