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CLIC2 Gene Mental retardation, X-linked type 32 NGS Genetic Test

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CLIC2 Gene Mental retardation, X-linked type 32 NGS Genetic Test

Short Name: CLIC2 Gene MRX32 NGS Test

Also known as: CLIC2 gene mental retardation, MRX32, X-linked intellectual disability type 32, CLIC2 gene mutation analysis

CLIC2 Gene Mental retardation, X-linked type 32 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are available in 3 to 4 weeks from the date the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestMale (primarily); female carrier testing availablePediatric, Adolescent, Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this CLIC2 gene mental retardation, X-linked type 32 NGS genetic test is to identify pathogenic or likely pathogenic variants in the CLIC2 gene that can confirm a clinical diagnosis, guide medical and behavioral management, and provide accurate recurrence-risk information to the family.

Test Code
4278
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are available in 3 to 4 weeks from the date the sample reaches the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation or fasting is required. A pre-test genetic counseling session is recommended to draw a pedigree chart, explain inheritance pattern, and obtain informed consent.

Method: Venipuncture for blood sample; FTA card spot; or submit extracted DNA

Step 2

Laboratory Analysis

A blood sample is collected by venipuncture into an EDTA tube. For FTA card collection, a few drops of blood are applied to the card. Extracted DNA samples should be submitted in a sterile tube with proper labeling.

Step 3

Report Delivery

There is no downtime. The patient can resume normal activities immediately. The sample will be transported to the laboratory at room temperature.

Timeline: Reports are available in 3 to 4 weeks from the date the sample reaches the laboratory.

Patient Instructions

1
Before the Test:A genetic counseling session is required to discuss the clinical features, X-linked inheritance pattern, and possible results of CLIC2 gene testing.
2
During the Test:The test involves submitting a blood or FTA card sample. The laboratory then performs DNA extraction, target enrichment, next-generation sequencing and bioinformatics analysis.
3
After the Test:After sample submission, the laboratory generates a written report in 3 to 4 weeks. The result must be discussed with the referring physician or genetic counselor.

About This Test

Who Should Get This Test

The purpose of this CLIC2 gene mental retardation, X-linked type 32 NGS genetic test is to identify pathogenic or likely pathogenic variants in the CLIC2 gene that can confirm a clinical diagnosis, guide medical and behavioral management, and provide accurate recurrence-risk information to the family.

How to Prepare

  • Please carry the lab requisition form mentioning clinical history.
  • A genetic counseling session must be completed before sample collection.
  • No fasting is required.
  • All samples must be labeled with patient name and unique ID.
  • In case of FTA card, allow the blood spots to air dry completely.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"If the child has unexplained intellectual disability with behavioral problems, seizures or dysmorphic features, genetic testing should be considered early. A CLIC2 NGS test can give a clear diagnosis and help parents understand recurrence risk in the family."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA blood tube / FTA card / Sterile DNA collection tube
Collection MethodVenipuncture for blood sample; FTA card spot; or submit extracted DNA
Sample Rejection Criteria:
  • Unlabeled or mislabeled sample
  • Hemolyzed, clotted or degraded blood specimen
  • Incomplete clinical history or missing consent
  • FTA card with insufficient blood spots

Understanding Your Results

The interpretation should be performed by a clinical geneticist in the context of the patient's clinical presentation and family history.
📊

Clinical action: Confirms the diagnosis of CLIC2-related X-linked type 32 mental retardation. Genetic counseling, family testing and medical follow-up are recommended.

📊

Clinical action: No CLIC2-related mutation was found. A broader genetic evaluation including intellectual disability NGS panels or chromosomal microarray should be considered.

📊

Clinical action: The variant cannot yet be classified as harmful or benign. Family segregation studies and additional clinical correlation are needed.

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist if the child has unexplained intellectual disability, global developmental delay, seizures, behavioral problems, or a family history of X-linked intellectual disability. Also seek genetic counseling if a positive or VUS result is received.

Limitations

  • ⚠This NGS test is limited to the CLIC2 gene and its clinically relevant splice-site regions.
  • ⚠Large deletions, duplications or structural rearrangements involving CLIC2 may not be detected by this sequencing test.
  • ⚠A negative test does not rule out other genetic or non-genetic causes of intellectual disability.
  • ⚠A variant of uncertain significance requires additional segregation studies and clinical correlation.

Risks & Considerations

  • ●Minimal risk of slight pain, bruising, or bleeding at the blood collection site
  • ●Rare vasovagal reaction during venipuncture
  • ●Risk of needle injury is minimized by trained phlebotomists

Interfering Factors

  • ●Degraded or contaminated DNA sample
  • ●Maternal cell contamination in neonatal blood samples
  • ●Incorrect or incomplete family history
  • ●Failure to complete pretest genetic counseling session

Compare With Similar Tests

TestCLIC2 Gene Mental retardation, X-linked type 32 NGS Genetic Test
ComparisonCLIC2 Gene Mental retardation, X-linked type 32 NGS Genetic Test

Frequently Asked Questions

What is the CLIC2 gene mental retardation X-linked type 32 NGS genetic test?
It is a targeted next-generation sequencing test that analyzes the CLIC2 gene for disease-causing variants associated with X-linked type 32 mental retardation and related neurodevelopmental symptoms.
What are the common symptoms of CLIC2-related mental retardation?
Common symptoms include intellectual disability, delayed development, behavioral problems, seizures, speech and language delay, low muscle tone, abnormal facial features, abnormal head size, hyperactivity and aggressive behavior.
How is CLIC2 gene mental retardation diagnosed?
Clinical examination and family history raise suspicion. Confirmatory diagnosis requires genetic testing using NGS or targeted sequencing to identify a pathogenic variant in the CLIC2 gene.
What is the cost of this CLIC2 gene NGS test in India?
The cost is around Rs 20000.0 at DNA Labs India. Free home sample collection is included for online bookings across many cities in India.
What type of sample is required?
The test can be performed on blood, extracted DNA, or one drop of blood on an FTA card. The sample must be properly labeled and accompanied by clinical history.
Is fasting required before the test?
No, fasting is not required for the CLIC2 gene NGS genetic test.
Do I need genetic counseling before this test?
Yes. Pre-test genetic counseling is recommended to draw a pedigree chart and discuss the X-linked inheritance pattern, benefits, risks and limitations of this genetic test.
How long does the test report take?
The laboratory report is usually provided in 3 to 4 weeks after the sample reaches the laboratory.
What does a positive result mean?
A positive result means a pathogenic or likely pathogenic variant was found in the CLIC2 gene, confirming the diagnosis of X-linked type 32 mental retardation.
What does a negative result mean?
A negative result means no pathogenic/likely pathogenic variant was detected in the CLIC2 gene. However, other genetic causes of intellectual disability should still be considered.
What is a variant of uncertain significance (VUS)?
A VUS is a genetic change whose association with the disease is not yet clearly known. Further testing of affected and unaffected family members can help clarify its significance.
Will insurance cover this genetic test?
Insurance coverage depends on the individual policy and scheme. Government schemes such as PMJAY, CGHS, ECHS and ESIC may not cover this test routinely; please confirm before booking.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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