COL15A1 Gene Early Onset Glaucoma, Phenotype Modifier of, COL15A1 Related NGS Genetic Test
Short Name: COL15A1 NGS Genetic Test
Also known as: COL15A1 Gene Test, Early Onset Glaucoma Genetic Test, Phenotype Modifier COL15A1 Test, Glaucoma NGS Test
COL15A1 Gene Early Onset Glaucoma, Phenotype Modifier of, COL15A1 Related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To identify pathogenic mutations in the COL15A1 gene that may modify the phenotype of early onset glaucoma, aiding in risk assessment, genetic counseling, and personalized treatment planning.
- Test Code
- 1481
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3-4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No specific preparation is required. Ensure proper identification and documentation of patient details. A genetic counseling session is recommended to discuss family history and draw a pedigree chart.
Method: Blood/Saliva Collection
Laboratory Analysis
Blood sample is collected via venipuncture by a trained phlebotomist. Alternatively, saliva or blood on FTA card can be used based on protocol.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Store the sample as per guidelines and transport to the laboratory promptly.
Timeline: 3-4 weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify pathogenic mutations in the COL15A1 gene that may modify the phenotype of early onset glaucoma, aiding in risk assessment, genetic counseling, and personalized treatment planning.
How to Prepare
- Use sterile equipment and follow aseptic techniques.
- Label samples accurately with patient information.
- For blood on FTA card, ensure proper spotting and drying.
- Maintain sample at ambient temperature during transport unless specified otherwise.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for COL15A1 mutations can aid in risk stratification and personalized management of early onset glaucoma, potentially preventing vision loss."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or lipemic blood samples
- Insufficient sample volume
- Incorrect labeling or documentation
- Sample contamination or degradation
Understanding Your Results
Positive for pathogenic COL15A1 variants
Increased risk of early onset glaucoma modification. Recommend ophthalmological monitoring, lifestyle modifications, and genetic counseling.
Negative for pathogenic variants
No detected mutations in COL15A1. However, glaucoma risk may still exist due to other genetic or environmental factors. Continue regular eye check-ups.
Variant of uncertain significance (VUS)
Genetic variant found with unclear clinical impact. Further research or family studies may be needed. Consult with a genetic specialist.
If you experience symptoms like blurred vision, eye pain, or halos around lights, or if you have a family history of early onset glaucoma. Also, consult after receiving test results for personalized management.
Limitations
- ⚠This test may not detect all genetic variants due to technical limitations of NGS.
- ⚠Results require clinical correlation and are not solely diagnostic for glaucoma.
- ⚠Genetic variants of uncertain significance may be identified, necessitating further analysis.
Risks & Considerations
- ●Minimal physical risks from blood draw, such as bruising or infection.
- ●Potential emotional impact from genetic results, including anxiety or stress.
- ●Risk of misinterpretation without proper genetic counseling.
Interfering Factors
- ●Sample contamination during collection or transport
- ●Improper storage conditions affecting DNA integrity
- ●Presence of inhibitors in the sample affecting NGS sequencing
Frequently Asked Questions
What is the COL15A1 Gene Early Onset Glaucoma Genetic Test?
Who should consider this test?
What sample types are accepted?
How long does it take to get results?
What is the cost of the test?
Is the test painful?
What does a positive result mean?
Can this test diagnose glaucoma?
Is genetic counseling provided?
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Is home sample collection available?
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₹5,100Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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