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SERPING1 Gene Angioedema, hereditary NGS Genetic Test

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SERPING1 Gene Angioedema, hereditary NGS Genetic Test

Short Name: SERPING1 Gene Angioedema Test

Also known as: Hereditary Angioedema NGS Test, SERPING1 Mutation Test, HAE Genetic Test

SERPING1 Gene Angioedema, hereditary NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS) Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the SERPING1 Gene Angioedema NGS Genetic Test is to detect mutations in the SERPING1 gene that cause hereditary angioedema (HAE). This test aids in confirming diagnosis, differentiating HAE from other types of angioedema, guiding treatment decisions, and enabling family screening for at-risk individuals.

Test Code
2546
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation such as fasting is required. Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Venipuncture for blood sample or DNA extraction from cheek swab

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture, or a cheek swab for DNA extraction. For FTA card, a single drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Store samples as instructed for stability.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:No fasting required. Provide clinical history and undergo genetic counseling to assess family history and symptoms.
2
During the Test:Sample collection via blood draw or cheek swab. The procedure is minimally invasive and takes a few minutes.
3
After the Test:Apply pressure to the collection site. Results will be available in 3 to 4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of the SERPING1 Gene Angioedema NGS Genetic Test is to detect mutations in the SERPING1 gene that cause hereditary angioedema (HAE). This test aids in confirming diagnosis, differentiating HAE from other types of angioedema, guiding treatment decisions, and enabling family screening for at-risk individuals.

How to Prepare

  • Ensure the patient has provided detailed clinical history of angioedema symptoms.
  • Complete a genetic counseling session to document family history and draw a pedigree chart.
  • Use sterile equipment for blood collection or DNA swabbing.
  • Label samples correctly with patient details and test information.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for SERPING1 mutations is crucial for diagnosing hereditary angioedema and guiding personalized treatment plans to manage symptoms and prevent life-threatening episodes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture for blood sample or DNA extraction from cheek swab

Sample Stability

Blood samples: Stable at room temperature for up to 48 hours.
Extracted DNA: Stable at -20°C for long-term storage.
FTA Card: Stable at room temperature for several weeks.
Sample Rejection Criteria:
  • Samples that are hemolyzed, clotted, or improperly labeled.
  • Insufficient sample volume or degraded DNA.
  • Samples without accompanying clinical history or consent.

Understanding Your Results

Results from the SERPING1 Gene Angioedema NGS Genetic Test indicate the presence or absence of pathogenic mutations in the SERPING1 gene. Interpretation should be done by a qualified geneticist or healthcare provider in correlation with clinical findings.
Mutation Detected: Consistent with a diagnosis of hereditary angioedema (HAE) due to SERPING1 deficiency. This confirms genetic etiology and guides treatment.
No Mutation Detected: Reduces the likelihood of SERPING1-related HAE, but does not exclude other forms of angioedema. Further clinical evaluation may be needed.
Variant of Uncertain Significance (VUS): A genetic change with unknown clinical significance. Repeat testing or family studies may be recommended.
⚠️ When to Consult a Doctor:

Consult a doctor or genetic counselor if you experience recurrent angioedema symptoms, have a family history of HAE, or if test results indicate a mutation or uncertain variant. Immediate medical attention is needed for severe swelling affecting breathing.

Limitations

  • ⚠This test only detects mutations in the SERPING1 gene and may not identify other genetic causes of angioedema.
  • ⚠Results require interpretation by a genetic counselor or healthcare provider in the context of clinical symptoms.
  • ⚠False negatives are possible if mutations are in regions not covered by the test.

Risks & Considerations

  • ●Minor bruising or discomfort at the blood collection site.
  • ●Rare risk of infection or fainting during venipuncture.
  • ●Psychological impact of genetic results; counseling is recommended.

Frequently Asked Questions

What is SERPING1 gene angioedema?
SERPING1 gene angioedema is a form of hereditary angioedema (HAE) caused by mutations in the SERPING1 gene, leading to deficiency of C1 inhibitor protein and recurrent episodes of severe swelling.
What are the symptoms of SERPING1 gene angioedema?
Symptoms include sudden swelling in the face, hands, feet, or genitals, abdominal pain, nausea, vomiting, difficulty breathing, and hoarseness, which can be life-threatening if the airway is affected.
How is SERPING1 gene angioedema diagnosed?
Diagnosis involves genetic testing using NGS to detect mutations in the SERPING1 gene, along with clinical evaluation and family history assessment.
What is the cost of the SERPING1 Gene Angioedema NGS Genetic Test in India?
The test costs INR 20000 at DNA Labs India, which includes home sample collection across India.
What sample is required for this test?
The test can be performed using a blood sample, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What does a positive result mean?
A positive result indicates a mutation in the SERPING1 gene, confirming hereditary angioedema and guiding treatment and management strategies.
What if no mutation is detected?
If no mutation is detected, it reduces the likelihood of SERPING1-related HAE, but other causes of angioedema should be investigated with further tests.
Is genetic counseling recommended?
Yes, genetic counseling is recommended before and after testing to understand results, assess family risk, and plan management.
Can this test be used for family screening?
Yes, if a mutation is identified, family members can be tested to determine their risk and enable early intervention.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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