COX15 Gene Leigh syndrome NGS Genetic Test
Short Name: COX15 NGS Genetic Test
Also known as: COX15 Gene Leigh Syndrome NGS Genetic Test, COX15 Mutation Analysis, COX15-Related Leigh Syndrome NGS Test
COX15 Gene Leigh syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify disease-causing pathogenic variants in the COX15 gene using next-generation sequencing. This supports a molecular diagnosis of COX15-related Leigh syndrome, helps guide clinical management, and provides information for genetic counselling and family planning.
- Test Code
- 4166
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
A genetic counselling session and clinical history review are recommended before testing. Please bring any relevant imaging, metabolic reports, and family history details. No fasting is required.
Method: Venipuncture or FTA card blood spot
Laboratory Analysis
A small blood sample will be collected from a vein, or a few drops of blood may be collected on an FTA card. The procedure is quick and routine.
Report Delivery
No special precautions are required after sample collection. You can resume normal activities immediately after the sample is taken.
Timeline: Reports are generally available within 3 to 4 weeks after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify disease-causing pathogenic variants in the COX15 gene using next-generation sequencing. This supports a molecular diagnosis of COX15-related Leigh syndrome, helps guide clinical management, and provides information for genetic counselling and family planning.
How to Prepare
- Submit the completed genetic counselling and consent documents.
- Provide accurate clinical and family history details at the time of booking.
- Label the blood sample or FTA card clearly with the patient's name and unique ID.
- Ensure extracted DNA, if provided, is labelled with the source and date of extraction.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"COX15-related Leigh syndrome is a complex mitochondrial disorder. Genetic counselling is essential to interpret the result in the context of the family history and clinical presentation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
- Clotted or haemolysed blood sample may be rejected.
- Insufficient sample quantity may require a repeat collection.
- Mislabelled samples or samples without matching requisition forms may not be processed.
- Expired or contaminated FTA cards may be rejected.
Understanding Your Results
Consult a neurologist or genetics specialist if you or a child has unexplained developmental regression, hypotonia, seizures, visual or hearing loss, or a confirmed family history of Leigh syndrome.
Limitations
- ⚠This NGS test is designed to evaluate variants in the COX15 gene; it does not comprehensively evaluate all other nuclear mitochondrial genes or mitochondrial DNA.
- ⚠Certain variant types such as large structural rearrangements or deep intronic variants may not be detected by this assay.
- ⚠A negative result does not exclude Leigh syndrome caused by variants in other genes.
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the blood collection site.
- ●Rare possibility of infection at the venepuncture site.
- ●No direct medical risk is associated with the genetic analysis itself.
Interfering Factors
- ●No dietary or fasting interference is known for this DNA-based test.
- ●Poor DNA quality or insufficient sample quantity may affect test success.
- ●Mislabelled samples or inappropriate sample containers may require repeat collection.
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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