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DNA Labs India

Cryoglobulins Panel Test

DNA Labs India | ISO 9001:2015 Certified

Cryoglobulins Panel Test

Short Name: Cryoglobulins Panel

Also known as: Cryoglobulin Panel, Cryoglobulinemia Panel, Cryoglobulins Immunofixation

Cryoglobulins Panel Test test available at DNA Labs India for ₹8,000. Uses Immunofixation Electrophoresis on Serum samples. Results in Sample daily by 9 am; report in 5 days.. Free home collection in 300+ cities across India.

Physician🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect and classify cryoglobulins in serum, aiding evaluation of cryoglobulinemia, vasculitis, and complement disorders.

Test Code
3458
Price
₹8,000
Sample Type
Serum
Result Time
Sample daily by 9 am; report in 5 days.
Fasting Required
No
Method
Immunofixation Electrophoresis
Step 1

Sample Collection

No special preparation required.

Method: Venipuncture using prewarmed syringe and needle at 37°C

Step 2

Laboratory Analysis

Blood is collected in a prewarmed Red Top (No Additive) tube using a prewarmed syringe and needle at 37°C. The sample should be kept warm until serum separation.

Step 3

Report Delivery

Allow the sample to clot at 37°C; centrifuge preferably at 37°C; separate serum and transport at room temperature. Do not freeze. Do not use SST gel barrier tubes.

Timeline: Sample daily by 9 am; report in 5 days.

Patient Instructions

1
Before the Test:No special preparation required. Inform the collection team if you have difficulty with venipuncture or bleeding.
2
During the Test:A small blood sample is drawn using a prewarmed syringe and needle. Keep the sample warm and avoid cooling before processing.
3
After the Test:Allow the sample to clot at 37°C and separate serum at room temperature. You may resume normal activities after collection.

About This Test

Who Should Get This Test

To detect and classify cryoglobulins in serum, aiding evaluation of cryoglobulinemia, vasculitis, and complement disorders.

How to Prepare

  • No special preparation required.
  • Collect blood in a prewarmed Red Top (No Additive) tube.
  • Use a prewarmed syringe and needle at 37°C.
  • Allow to clot and centrifuge preferably at 37°C.
  • Separate serum and transport at room temperature.
  • Do not freeze. Do not use SST gel barrier tubes.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Cryoglobulin testing requires strict temperature control. Prewarmed collection tubes and avoidance of SST/freezing are essential to prevent false-negative results."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume3 mL (1.5 mL min.)
ContainerPrewarmed Red Top (No Additive) tube
Collection MethodVenipuncture using prewarmed syringe and needle at 37°C

Sample Stability

Room Temperature: 72 hrs
Refrigerator: NA
Frozen: NA
Sample Rejection Criteria:
  • SST gel barrier tube received
  • Frozen sample
  • Sample not maintained at 37°C before serum separation
  • Insufficient sample volume (<1.5 mL)

Understanding Your Results

A negative cryoglobulins panel means no significant cryoprecipitate was detected under controlled warm collection. A positive result indicates the presence of cryoglobulins, and immunofixation helps classify them as monoclonal, polyclonal, or mixed. Results should be interpreted by the referring specialist in the context of symptoms and additional workup.
Negative: No cryoglobulins detected.
Positive with monoclonal cryoglobulins: May be associated with lymphoproliferative disorders.
Positive with mixed or polyclonal cryoglobulins: May be associated with infections, autoimmune diseases, or chronic inflammation.
Discuss all positive results with a specialist for further evaluation.
⚠️ When to Consult a Doctor:

Consult your doctor if you have joint pain, skin rash, numbness, weakness, abdominal pain, or unexplained renal symptoms, or if your cryoglobulins panel is positive.

Limitations

  • ⚠Requires strict temperature control; improper collection may affect accuracy.
  • ⚠A positive result is not disease-specific and requires correlation with clinical findings and other tests.
  • ⚠Immunofixation identifies the immunoglobulin type but not the underlying cause.

Risks & Considerations

  • ●Mild pain or bruising at the venipuncture site
  • ●Rarely, dizziness or lightheadedness during blood draw
  • ●Infection at puncture site is extremely rare

Interfering Factors

  • ●Use of SST gel barrier tubes may interfere with cryoglobulin precipitation.
  • ●Cooling of the sample during collection, clotting, or transport can cause false-negative results.
  • ●Freezing the sample is not acceptable; it may destroy or mask cryoglobulin complexes.

Compare With Similar Tests

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Frequently Asked Questions

What is a Cryoglobulins Panel Test?
It is a blood test that detects abnormal proteins called cryoglobulins in the blood using immunofixation electrophoresis, mainly for suspected cryoglobulinemia or vasculitis.
What symptoms suggest needing this test?
Symptoms may include joint pain and stiffness, purplish skin rash or livedo reticularis, numbness or tingling in hands and feet, weakness, fatigue, abdominal pain, and renal failure.
Do I need to fast before the test?
No special preparation or fasting is required before the Cryoglobulins Panel Test.
How is the sample collected?
Blood is collected in a prewarmed Red Top (No Additive) tube using a prewarmed syringe and needle at 37°C. SST gel barrier tubes and freezing must be avoided.
What method is used for testing?
The test uses Immunofixation Electrophoresis to detect and classify cryoglobulins.
What is the price of the test?
The test costs Rs 8000 at DNA Labs India, with free home sample collection for online bookings across India.
When are reports available?
Samples are accepted daily by 9 am, and reports are typically available within 5 days.
What does a positive test mean?
A positive result means cryoglobulins were detected. Your doctor may order additional tests to determine the underlying cause.
What sample stability is required?
The sample is stable at room temperature for 72 hours. Do not refrigerate or freeze the sample.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings for the Cryoglobulins Panel Test.
Which doctor should I consult?
Consult your doctor if cryoglobulinemia is suspected. Depending on symptoms, an allergist/immunologist or rheumatologist may be involved in care.
Is insurance coverage available?
Coverage depends on the scheme. PMJAY, CGHS, ECHS, ESIC, and private insurance should be checked for specific coverage.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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