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CST3 Gene Cerebral Amyloid Angiopathy NGS Genetic Test

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CST3 Gene Cerebral Amyloid Angiopathy NGS Genetic Test

Short Name: CST3 Gene CAA NGS Test

Also known as: CST3 Gene Cerebral Amyloid Angiopathy Genetic Test, CST3 Mutation Analysis for CAA

CST3 Gene Cerebral Amyloid Angiopathy NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the CST3 gene that increase the risk of developing cerebral amyloid angiopathy, aiding in diagnosis, genetic counselling, and family planning for at-risk individuals.

Test Code
1545
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Provide detailed clinical history and family pedigree for accurate genetic counselling.

Method: Venipuncture for blood samples or use of FTA card for one drop blood

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture or use an FTA card for one drop blood, following sterile procedures.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Store the sample at room temperature as per instructions.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Consult with a healthcare provider to discuss the need for genetic testing, provide a detailed family history, and understand the implications of results.
2
During the Test:The test involves a simple blood draw or use of an FTA card, typically completed within minutes with minimal discomfort.
3
After the Test:Results will be available in 3 to 4 weeks. Follow up with a genetic counsellor or neurologist for interpretation and next steps.

About This Test

Who Should Get This Test

To identify mutations in the CST3 gene that increase the risk of developing cerebral amyloid angiopathy, aiding in diagnosis, genetic counselling, and family planning for at-risk individuals.

How to Prepare

  • Use sterile equipment and aseptic techniques
  • Label samples correctly with patient details
  • Transport blood or DNA samples at ambient room temperature
  • Ensure proper documentation of clinical history and consent

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CST3 mutations can aid in early detection and management of cerebral amyloid angiopathy, particularly for individuals with a family history or symptoms suggesting neurological disorders."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA tube or FTA card
Collection MethodVenipuncture for blood samples or use of FTA card for one drop blood

Sample Stability

Blood samples: stable for up to 48 hours at room temperature
Extracted DNA: stable for longer periods when stored appropriately
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improper labeling or missing documentation
  • Samples contaminated or not transported as required

Understanding Your Results

Test results indicate the presence or absence of pathogenic mutations in the CST3 gene, which are linked to cerebral amyloid angiopathy risk.
📊

Negative

No pathogenic CST3 mutation detected, suggesting a lower genetic risk for cerebral amyloid angiopathy. Clinical evaluation is still recommended if symptoms persist.

📊

Positive

Pathogenic CST3 mutation detected, indicating an increased genetic risk for cerebral amyloid angiopathy. Further clinical evaluation, monitoring, and genetic counselling are advised.

⚠️ When to Consult a Doctor:

Consult a healthcare professional if experiencing symptoms like severe headaches, confusion, memory loss, or stroke-like symptoms, or if genetic test results show positive mutations for CST3 gene.

Limitations

  • ⚠May not detect all possible mutations in the CST3 gene
  • ⚠Results require clinical correlation with symptoms and family history
  • ⚠Genetic testing cannot predict the onset or severity of CAA with certainty

Risks & Considerations

  • ●Minor bruising or pain at the blood collection site
  • ●Rare risk of infection or hematoma
  • ●Emotional impact of genetic results, requiring counselling support

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Technical errors during sequencing or analysis
  • ●Patient's recent blood transfusions or DNA-altering treatments

Frequently Asked Questions

What is the CST3 Gene Cerebral Amyloid Angiopathy NGS Genetic Test?
It is a Next-Generation Sequencing test that detects mutations in the CST3 gene associated with cerebral amyloid angiopathy, a neurological disorder involving amyloid buildup in brain blood vessels.
Who should consider taking this genetic test?
Individuals with a family history of cerebral amyloid angiopathy, symptoms like recurrent headaches or cognitive decline, or those undergoing genetic counselling for neurological disorders.
What does the test detect?
The test identifies pathogenic mutations in the CST3 gene that may increase the risk of developing cerebral amyloid angiopathy.
How is the test performed?
A blood sample is collected via venipuncture or a drop of blood on an FTA card, and DNA is analyzed using Next-Generation Sequencing technology.
What is the cost of the test in India?
The cost is INR 20,000, which includes sample collection, analysis, and reporting, with free home collection available in many cities.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across numerous cities in India.
How long does it take to get the results?
Results are typically delivered within 3 to 4 weeks after sample collection.
What do the results mean?
A negative result indicates no pathogenic mutation detected, while a positive result suggests a genetic risk for cerebral amyloid angiopathy, requiring further clinical evaluation.
Are there any risks associated with the test?
The test involves minimal risks, such as minor bruising from blood draw, but genetic results may have emotional implications, so genetic counselling is recommended.
Can the test be used for family planning?
Yes, it can inform genetic counselling for family planning by assessing hereditary risk of cerebral amyloid angiopathy.
What is cerebral amyloid angiopathy?
Cerebral amyloid angiopathy is a condition where amyloid protein deposits in brain blood vessels, potentially leading to bleeding, stroke, and neurological symptoms.
How accurate is the NGS genetic test?
NGS technology provides high accuracy in detecting gene mutations, but results should be interpreted in conjunction with clinical findings and family history.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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