CUL4B Gene Mental retardation, X-linked type 15 NGS Genetic Test
Short Name: CUL4B MRX15 NGS Test
Also known as: CUL4B-related intellectual disability, X-linked intellectual disability 15
CUL4B Gene Mental retardation, X-linked type 15 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the CUL4B Gene Mental Retardation, X-linked Type 15 NGS Genetic Test is to diagnose genetic mutations in the CUL4B gene that cause X-linked intellectual disability. This test helps confirm clinical suspicions, differentiates from other genetic disorders, provides information for prognosis and management, and supports genetic counseling for affected individuals and their families.
- Test Code
- 1695
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A genetic counseling session is recommended to discuss the test, draw a pedigree chart of family history, and obtain informed consent. Clinical history of the patient should be reviewed. No fasting is required, and samples should be stored at ambient room temperature.
Method: Venipuncture
Laboratory Analysis
Blood sample is collected via venipuncture from a vein in the arm. For FTA card, a finger-prick blood drop is used. The procedure is quick and minimally invasive.
Report Delivery
The blood sample or FTA card is labeled, stored properly, and transported to the laboratory under appropriate conditions. Post-collection care includes standard bandaging and observation for any adverse effects.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the CUL4B Gene Mental Retardation, X-linked Type 15 NGS Genetic Test is to diagnose genetic mutations in the CUL4B gene that cause X-linked intellectual disability. This test helps confirm clinical suspicions, differentiates from other genetic disorders, provides information for prognosis and management, and supports genetic counseling for affected individuals and their families.
How to Prepare
- Use sterile blood collection tubes or FTA cards
- Label samples accurately with patient details
- Store blood samples at ambient temperature if extracting DNA later
- Avoid hemolysis during collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for diagnosing CUL4B gene mutations causing X-linked intellectual disability, aiding in accurate diagnosis, management, and family counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed samples
- Insufficient sample volume
- Contaminated samples
- Incorrectly labeled samples
- Samples not collected per instructions
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of X-linked mental retardation type 15 due to CUL4B mutation. Genetic counseling and further clinical management recommended.
Negative for pathogenic variant
No detectable mutations in the CUL4B gene. However, clinical symptoms may still be due to other genetic or non-genetic causes.
Variant of uncertain significance (VUS)
A genetic variant was detected but its clinical significance is unknown. Further testing or family studies may be needed.
Inconclusive
Test could not provide a definitive result due to technical issues. Repeat testing or alternative methods may be considered.
Consult a geneticist or neurologist immediately after receiving positive or uncertain results. Also, consult if symptoms persist despite negative results, or for guidance on treatment and family planning.
Limitations
- ⚠May not detect all types of mutations (e.g., large deletions/duplications if not covered by NGS panel)
- ⚠Results require interpretation by a genetic specialist
- ⚠Not all genetic variants have known clinical significance
Risks & Considerations
- ●Minor pain or bruising at blood draw site
- ●Minimal risk of infection
- ●Fainting or dizziness in rare cases
Interfering Factors
- ●Hemolyzed or degraded blood samples
- ●Contamination during sample collection
- ●Insufficient sample volume
- ●Incorrect sample storage conditions
Compare With Similar Tests
| Test | CUL4B Gene Mental retardation, X-linked type 15 NGS Genetic Test | Fragile X Syndrome Genetic Test | Rett Syndrome Genetic Test | General Intellectual Disability Panel | Chromosomal Microarray Analysis |
|---|---|---|---|---|---|
| Comparison | CUL4B Gene Mental retardation, X-linked type 15 NGS Genetic Test |
Frequently Asked Questions
What is the CUL4B Gene Mental Retardation NGS Genetic Test?
What are the symptoms of CUL4B gene mutation?
How is the test performed?
What is the cost of this test in India?
Is home sample collection available?
How long does it take to get results?
Is this test covered by insurance?
Who should consider getting this test?
What is X-linked inheritance?
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