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DARS Gene Hypomyelination with brainstem and spinal cord involvement and leg spasticity NGS Genetic Test

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DARS Gene Hypomyelination with brainstem and spinal cord involvement and leg spasticity NGS Genetic Test

Short Name: DARS HBSL NGS Genetic Test

Also known as: DARS Gene Related Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity, DARS NGS Genetic Test

DARS Gene Hypomyelination with brainstem and spinal cord involvement and leg spasticity NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

This test is intended to detect clinically significant variants in the DARS gene in patients with suspected hypomyelination with brainstem and spinal cord involvement and leg spasticity. It offers a molecular diagnosis to support clinical management, genetic counselling, family screening, and informed reproductive planning.

Test Code
4151
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Fasting is not needed. A genetic counselling session with clinical history and pedigree chart should be completed prior to testing.

Method: Peripheral blood collection or FTA card spot

Step 2

Laboratory Analysis

A small blood sample is drawn or one drop of blood is placed on an FTA card. The procedure is quick and routine.

Step 3

Report Delivery

You can resume normal activities immediately. The sample will be transported to the laboratory for NGS analysis.

Timeline: 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:No fasting required. Schedule a genetic counselling session and discuss symptoms and family history with your doctor.
2
During the Test:A blood sample or FTA card sample will be collected. The process takes only a few minutes.
3
After the Test:No downtime is needed. The report will be shared through online portal, email, or WhatsApp within 3 to 4 weeks.

About This Test

Who Should Get This Test

This test is intended to detect clinically significant variants in the DARS gene in patients with suspected hypomyelination with brainstem and spinal cord involvement and leg spasticity. It offers a molecular diagnosis to support clinical management, genetic counselling, family screening, and informed reproductive planning.

How to Prepare

  • No fasting required.
  • Complete genetic counselling and provide clinical history.
  • Free home sample collection can be arranged for online bookings.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This targeted gene test should ideally be ordered after clinical evaluation and neuroimaging by a neurologist or geneticist. It provides a molecular answer that can help with management and counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per sample type: blood, extracted DNA, or one drop blood on FTA card
ContainerEDTA tube / DNA vial / FTA card
Collection MethodPeripheral blood collection or FTA card spot

Sample Stability

FTA card: stable at ambient room temperature during transport.
Whole blood in EDTA: as per laboratory transport protocol.
Extracted DNA: stored as per laboratory guidelines, typically at -20°C.
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient DNA or sample volume
  • Mislabeled sample
  • Missing clinical details or consent

Understanding Your Results

The result should be interpreted by a clinical geneticist in the context of the patient's clinical presentation, neuroimaging findings, and family history.
📊

Pathogenic variant detected

Molecular confirmation of DARS-related hypomyelination with brainstem and spinal cord involvement and leg spasticity.

📊

Likely pathogenic variant detected

Strongly supports the diagnosis; correlation with clinical and imaging findings is recommended.

📊

Variant of uncertain significance (VUS)

Further family testing and gene-specific studies may be required.

📊

No pathogenic/likely pathogenic variant detected

DARS-related diagnosis is not confirmed; broader genetic testing may be advised.

⚠️ When to Consult a Doctor:

Consult a neurologist or clinical geneticist if you or a family member experience leg spasticity, developmental delay, movement or coordination problems, swallowing difficulty, or visual, hearing, or speech abnormalities.

Limitations

  • ⚠This test targets only the DARS gene and may not detect mutations in other genes associated with similar clinical presentations.
  • ⚠NGS may not detect all types of variants, including large deletions, duplications, or deep intronic changes.
  • ⚠A variant of uncertain significance may require additional family studies and further evaluation.

Risks & Considerations

  • ●Minimal risk from blood collection; possible mild bruising at the puncture site.
  • ●Genetic testing may identify variants of uncertain significance.
  • ●Results may have psychological and family implications; genetic counselling is advised.

Interfering Factors

  • ●Inadequate DNA quantity or quality
  • ●Sample degradation due to improper storage or transport
  • ●Recent blood transfusion within 48 hours before collection
  • ●Sample mix-up or mislabelling

Compare With Similar Tests

TestDARS Gene Hypomyelination with brainstem and spinal cord involvement and leg spasticity NGS Genetic Test
ComparisonDARS Gene Hypomyelination with brainstem and spinal cord involvement and leg spasticity NGS Genetic Test

Frequently Asked Questions

What is DARS Gene Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity?
It is a rare genetic disorder caused by DARS gene mutations that affect myelin formation, leading to spasticity and neurological symptoms.
What does this NGS genetic test check?
It checks for mutations in the DARS gene using next-generation sequencing technology.
How much does the test cost at DNA Labs India?
The test costs Rs 20000.0 and includes genetic counselling and support.
What sample is required for this test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before the test?
No, fasting is not required.
How long will the report take?
The report is generally available in 3 to 4 weeks.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across India.
Who should undergo this test?
Individuals showing leg spasticity, developmental delay, movement or coordination problems, or with a family history of DARS gene-related hypomyelination.
What does a positive test result mean?
A pathogenic or likely pathogenic variant in the DARS gene strongly supports the diagnosis of this condition.
Does this test detect all genetic causes of hypomyelination?
No, this is a targeted test for the DARS gene only; a broader panel may be required if the result is negative.
Is genetic counselling needed before testing?
Yes, a genetic counselling session and clinical history with a pedigree chart are part of the pre-test process.
Will insurance cover this test?
Coverage depends on the plan; government schemes are not pre-authorized, while private insurance may cover part or all based on policy.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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