DCX Gene Lissencephaly/Subcortical laminal heteropia, X-linked NGS Genetic Test
Short Name: DCX Gene NGS Genetic Test
Also known as: DCX Gene Sequencing, X-linked lissencephaly genetic test, Subcortical laminal heteropia NGS test
DCX Gene Lissencephaly/Subcortical laminal heteropia, X-linked NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports will be shared within 3 to 4 weeks of the sample reaching the lab. You will receive an email/SMS notification when the report is available.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To detect mutations in the DCX gene for the diagnosis of X-linked lissencephaly and subcortical band heterotopia, to confirm clinical or MRI findings, for carrier detection in at-risk females, and to provide accurate recurrence-risk information for affected families.
- Test Code
- 4214
- CPT Code
- 81479
- ICD Code
- Q04.8
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports will be shared within 3 to 4 weeks of the sample reaching the lab. You will receive an email/SMS notification when the report is available.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required for this genetic test. You may eat and drink normally. Please inform your doctor about any medications, prior genetic tests, or if you have had a bone marrow transplant (as it could affect the DNA result).
Method: Venipuncture or Fingerstick (for FTA card)
Laboratory Analysis
A trained phlebotomist will collect a blood sample from a vein in your arm. For FTA card sampling, a small finger prick will be performed and a drop of blood placed on the card. The procedure takes only a few minutes.
Report Delivery
You can resume your normal activities immediately. A small bruise may appear at the venipuncture site but will resolve on its own. No specific post-test care is needed for FTA card collection.
Timeline: Reports will be shared within 3 to 4 weeks of the sample reaching the lab. You will receive an email/SMS notification when the report is available.
Patient Instructions
About This Test
Who Should Get This Test
To detect mutations in the DCX gene for the diagnosis of X-linked lissencephaly and subcortical band heterotopia, to confirm clinical or MRI findings, for carrier detection in at-risk females, and to provide accurate recurrence-risk information for affected families.
How to Prepare
- Carry a valid government-issued photo ID for verification
- If you have had a prior genetic test, please bring the previous report for correlation
- For FTA card collection, ensure the blood spot is completely dry and free from contamination before sealing
- Avoid sharing the patient's identity information on the sample container
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"As a neurologist, I strongly recommend genetic testing for individuals with unexplained epilepsy, intellectual disability, or imaging findings suggestive of lissencephaly or subcortical band heterotopia. This NGS test for the DCX gene provides definitive diagnosis and supports informed family planning and genetic counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Incorrectly labeled or unlabeled samples
- Samples received without consent form or physician referral
- Samples contaminated or not stored appropriately
Understanding Your Results
Pathogenic variant detected
Confirms the diagnosis in symptomatic individuals; identifies carriers in asymptomatic female relatives.
Likely pathogenic variant detected
Highly likely causative; clinical correlation and family segregation studies are recommended.
Variant of uncertain significance (VUS)
Insufficient evidence to determine causality. Additional familial testing or functional studies may be needed.
No pathogenic variant detected
No evidence of a DCX gene mutation. Consider testing other genes or comprehensive lissencephaly panels.
Consult a neurologist or clinical geneticist if you or your child have unexplained seizures, intellectual disability, delayed developmental milestones, or brain MRI findings such as lissencephaly or subcortical band heterotopia. A referral for genetic counseling is recommended before and after testing.
Limitations
- ⚠NGS may not detect large genomic rearrangements, repeat expansion disorders, or mutations deep in non-coding regions unless specifically analyzed
- ⚠Variants of uncertain significance (VUS) may be reported and require further investigation
- ⚠This test only analyses the DCX gene; other genes associated with lissencephaly are not covered by this specific panel
Risks & Considerations
- ●Minor pain or bruising at the venipuncture site
- ●Very low risk of infection at the puncture site
- ●No significant long-term health risks from having a blood draw
Interfering Factors
- ●Presence of maternal DNA contamination (if fetal sample used)
- ●Low DNA quality or quantity
- ●Mosaic mutations may be under-detected
- ●Incorrect sample labeling or documentation
Compare With Similar Tests
| Test | DCX Gene Lissencephaly/Subcortical laminal heteropia, X-linked NGS Genetic Test | Targeted DCX Mutation Analysis | Lissencephaly Comprehensive Panel | Chromosomal Microarray (CMA) |
|---|---|---|---|---|
| Comparison | DCX Gene Lissencephaly/Subcortical laminal heteropia, X-linked NGS Genetic Test |
Frequently Asked Questions
What is the DCX gene and why is it important?
Who should consider taking this DCX gene NGS test?
How is the test performed?
What does a positive result mean?
What does a negative result mean?
Is fasting required before the test?
How long will it take to receive my reports?
Can females undergo this test?
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