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DCX Gene Lissencephaly, X-linked type 1 NGS Genetic Test

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DCX Gene Lissencephaly, X-linked type 1 NGS Genetic Test

Short Name: DCX Lissencephaly NGS Test

Also known as: X-linked lissencephaly type 1, DCX-related lissencephaly

DCX Gene Lissencephaly, X-linked type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose DCX Gene Lissencephaly, X-linked type 1 by identifying mutations in the DCX gene using next-generation sequencing technology, enabling accurate clinical management and genetic counseling.

Test Code
2751
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling recommended to discuss implications and obtain informed consent.

Method: Venipuncture for blood, FTA card collection

Step 2

Laboratory Analysis

Standard blood draw via venipuncture or FTA card collection following aseptic techniques.

Step 3

Report Delivery

Sample is labeled, stored appropriately, and sent to the laboratory for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test purpose, implications, and obtain informed consent.
2
During the Test:Sample collection via blood draw or FTA card, processed in the laboratory using NGS technology.
3
After the Test:Report generation within 3-4 weeks, followed by consultation to discuss results and next steps.

About This Test

Who Should Get This Test

To diagnose DCX Gene Lissencephaly, X-linked type 1 by identifying mutations in the DCX gene using next-generation sequencing technology, enabling accurate clinical management and genetic counseling.

How to Prepare

  • Ensure proper labeling of samples with patient details
  • Follow aseptic techniques to avoid contamination
  • Use correct sample containers as specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early diagnosis through NGS testing is crucial for managing symptoms, providing genetic counseling, and informing family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeVaries based on sample type
ContainerEDTA tube for blood, FTA card for one drop blood
Collection MethodVenipuncture for blood, FTA card collection

Sample Stability

Blood: 2-8°C for up to 48 hours
FTA card: Stable at room temperature for extended periods
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the DCX gene, aiding in the diagnosis of X-linked lissencephaly type 1.
Positive: Pathogenic mutation detected, confirming diagnosis of DCX Gene Lissencephaly.
Negative: No pathogenic variants found; clinical correlation and further testing may be needed.
Variant of Uncertain Significance (VUS): Mutation detected but clinical significance unclear; genetic counseling recommended.
⚠️ When to Consult a Doctor:

If symptoms such as developmental delay, seizures, or neurological abnormalities are present, or if there is a family history of lissencephaly, consult a geneticist or pediatric neurologist promptly.

Limitations

  • ⚠May not detect all types of mutations, such as large deletions or duplications not covered by NGS
  • ⚠Results require clinical correlation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Genetic implications for family members may require counseling

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Improper sample handling

Compare With Similar Tests

TestDCX Gene Lissencephaly, X-linked type 1 NGS Genetic Test
ComparisonDCX Gene Lissencephaly, X-linked type 1 NGS Genetic Test

Frequently Asked Questions

What is DCX Gene Lissencephaly, X-linked type 1?
It is a rare genetic disorder affecting brain development, caused by mutations in the DCX gene, leading to a smooth brain surface and neurological symptoms.
What are the common symptoms?
Symptoms include developmental delay, intellectual disability, seizures, microcephaly, abnormal muscle tone, coordination issues, and visual or hearing impairments.
How is this disorder diagnosed?
Diagnosis involves clinical evaluation, brain imaging (e.g., MRI showing lissencephaly), and genetic testing to confirm DCX gene mutations.
What is the NGS Genetic Test?
Next-generation sequencing (NGS) is a advanced genetic testing technology that accurately detects mutations in the DCX gene for diagnosis.
What is the cost of the test in India?
The test costs approximately INR 20000 at DNA Labs India, with potential discounts for online bookings.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted sample types.
Is fasting required for the test?
No, fasting is not required for this genetic test.
Who should consider this test?
Individuals with symptoms of developmental delay, seizures, or family history of X-linked lissencephaly, especially pediatric patients.
What are the treatment options?
There is no cure, but management includes seizure control, physical therapy, and supportive care; genetic counseling is recommended.
How accurate is the NGS test?
NGS is highly accurate for detecting DCX gene mutations, but results should be interpreted in clinical context by a geneticist.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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