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DEPDC5 Gene Epilepsy, familial focal with variable foci NGS Genetic Test

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DEPDC5 Gene Epilepsy, familial focal with variable foci NGS Genetic Test

Short Name: DEPDC5 FFEVF NGS Test

Also known as: DEPDC5 gene sequencing, DEPDC5 mutation analysis, FFEVF NGS genetic test

DEPDC5 Gene Epilepsy, familial focal with variable foci NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Samples are processed after they are received at the lab. Reports are delivered within 3 to 4 weeks.. Free home collection in 300+ cities across India.

NGS Genetic TestAll age groups🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to identify clinically significant sequence variants in the DEPDC5 gene associated with familial focal epilepsy with variable foci. The result helps confirm the genetic basis of a patient's epilepsy, supports treatment decisions, and enables predictive and reproductive counselling for at-risk family members.

Test Code
4072
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Samples are processed after they are received at the lab. Reports are delivered within 3 to 4 weeks.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. A neurologist or clinical geneticist should confirm the need for genetic testing. A genetic counselling session is recommended to record family history, draw a pedigree chart, and obtain informed consent before blood collection.

Method: Peripheral venous blood collection or finger prick for FTA card

Step 2

Laboratory Analysis

During the test, a health care professional may collect whole blood by venipuncture or a drop of blood from a finger prick onto an FTA card. The collection takes only a few minutes.

Step 3

Report Delivery

After collection, the sample is sent to the genetic laboratory for NGS analysis. The patient can resume normal daily activities immediately. Reports are issued in 3 to 4 weeks and should be discussed with the referring doctor and clinical geneticist.

Timeline: Samples are processed after they are received at the lab. Reports are delivered within 3 to 4 weeks.

Patient Instructions

1
Before the Test:No fasting is required. A neurologist or clinical geneticist will confirm the need for genetic testing. A counselling session should be completed to record family history and draw a pedigree, and informed consent is taken before blood collection.
2
During the Test:During the test, a health care professional may collect whole blood by venipuncture or a drop of blood from a finger prick onto an FTA card. The collection takes only a few minutes.
3
After the Test:After collection, the sample is sent to the genetic laboratory for NGS analysis. The patient can resume normal daily activities immediately. Reports are issued in 3 to 4 weeks and should be discussed with the referring doctor and clinical geneticist.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to identify clinically significant sequence variants in the DEPDC5 gene associated with familial focal epilepsy with variable foci. The result helps confirm the genetic basis of a patient's epilepsy, supports treatment decisions, and enables predictive and reproductive counselling for at-risk family members.

How to Prepare

  • Before the test, a genetic counselling session is recommended to draw a pedigree chart and discuss the implications of the test.
  • No fasting is required.
  • Sample can be collected as whole blood in an EDTA tube, extracted DNA, or one drop of blood on an FTA card.
  • Ensure the sample is labelled with the patient's name and unique identification number.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This genetic test should be ordered only after clinical assessment and appropriate counselling. In a woman with epilepsy, pre-conception and prenatal counselling is also important to review genetic implications and antiepileptic drug safety."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs instructed in the DNA Labs India collection kit
ContainerEDTA tube / FTA card / DNA tube
Collection MethodPeripheral venous blood collection or finger prick for FTA card

Sample Stability

Whole blood in EDTA should reach the laboratory within 24 to 48 hours of collection.
FTA blood spots are stable at ambient temperature for several days.
Extracted DNA is stable for several weeks under appropriate storage conditions.
Sample Rejection Criteria:
  • Insufficient sample quantity
  • Clotted blood in EDTA tube
  • Haemolysed sample
  • Samples without proper patient identification or consent
  • FTA card that is wet, contaminated, or not dried properly

Understanding Your Results

This test should be interpreted by a clinical geneticist in the context of the patient's full clinical picture, family history, and pedigree.
Pathogenic or likely pathogenic variant detected: Confirms the genetic diagnosis of DEPDC5-related FFEVF and allows targeted testing of relatives.
Variant of uncertain significance (VUS) detected: Does not confirm or exclude the diagnosis; additional segregation or functional studies may be needed.
No pathogenic variant detected: Indicates that no DEPDC5 disease-associated variant was identified in this test; non-genetic causes or variants in other epilepsy genes may still be possible.
⚠️ When to Consult a Doctor:

Consult a neurologist if you have recurrent focal seizures, childhood-onset epilepsy of unknown cause, or a family history of focal epilepsy. A clinical geneticist or an obstetrician-gynaecologist should be involved before and after this test for genetic counselling and reproductive planning.

Limitations

  • ⚠This test is focused on the DEPDC5 gene only and is not a comprehensive epilepsy panel.
  • ⚠Large deletions or duplications may not be reliably detected by this NGS sequencing test.
  • ⚠A negative result does not exclude all genetic or non-genetic causes of epilepsy.
  • ⚠A detected variant may require family segregation studies before a final diagnosis is confirmed.

Risks & Considerations

  • ●Rare: small risk of bruising, bleeding, or infection at the venipuncture site
  • ●Psychological impact of an unexpected genetic finding
  • ●No medical risk from FTA card fingerstick beyond minor discomfort

Interfering Factors

  • ●Poor DNA quality or quantity
  • ●Sample mix-up or mislabelling
  • ●NGS coverage gaps in some genomic regions
  • ●Variant of uncertain significance requiring further family testing
  • ●Contamination of blood or FTA card during collection

Compare With Similar Tests

TestDEPDC5 Gene Epilepsy, familial focal with variable foci NGS Genetic Test
ComparisonDEPDC5 Gene Epilepsy, familial focal with variable foci NGS Genetic Test

Frequently Asked Questions

What is the DEPDC5 gene epilepsy NGS genetic test?
It is a next-generation sequencing test that analyses the DEPDC5 gene to identify disease-causing variants linked to familial focal epilepsy with variable foci (FFEVF).
What is familial focal epilepsy with variable foci?
FFEVF is an inherited epilepsy syndrome in which different members of the same family may have focal seizures arising from different areas of the brain.
What symptoms are associated with DEPDC5 gene-related epilepsy?
Symptoms can include focal or generalised convulsive seizures, loss of awareness, unusual movements, headache, dizziness, nausea, anxiety, or depression. The severity and pattern differ between affected individuals.
Who should consider this DEPDC5 NGS test?
Patients with recurrent focal epilepsy of suspected genetic cause, a family history of epilepsy with variable seizure foci, or a known DEPDC5 variant in the family may consider this test after evaluation by a neurologist.
What sample types are accepted?
The test can be done on whole blood (EDTA tube), extracted DNA, or one drop of blood on an FTA card.
Is fasting required for this test?
No. Fasting is not required for the DEPDC5 gene NGS genetic test.
What is the cost of the DEPDC5 gene FFEVF NGS test in India?
The test price at DNA Labs India is Rs 20000.0, and a special discounted price of INR 20000 is offered for online bookings.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across multiple cities in India, including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, Pune, and others.
How long will the reports take?
Reports are usually ready in 3 to 4 weeks from the time the sample reaches DNA Labs India.
What does a positive result mean?
A positive result means a pathogenic or likely pathogenic variant in DEPDC5 was detected. This helps confirm the genetic diagnosis and allows testing of at-risk family members.
What does a negative result mean?
A negative result means no clinically significant variant was found in the DEPDC5 gene. It does not exclude all genetic or non-genetic causes of epilepsy.
Why is genetic counselling important before this test?
Genetic counselling before the test helps record family history, draw a pedigree, explain the possible outcomes, and obtain informed consent. After the result, counselling is needed to discuss implications for the patient and relatives.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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