Des-Gamma Carboxy Prothrombin (DCP)/PIVKA II Serum Test
Short Name: DCP/PIVKA II Test
Also known as: DCP Test, PIVKA II Test, Prothrombin Induced by Vitamin K Absence II Test
Des-Gamma Carboxy Prothrombin (DCP)/PIVKA II Serum Test test available at DNA Labs India for ₹5,000. Uses Chemiluminescent Microparticle Immunoassay on Serum samples. Results in Reports are typically available the same day if samples are received by 9 am.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To aid in the early detection, diagnosis, and monitoring of hepatocellular carcinoma (liver cancer), especially in high-risk populations, by measuring serum levels of DCP/PIVKA II.
- Test Code
- 483
- Price
- ₹5,000
- Sample Type
- Serum
- Result Time
- Reports are typically available the same day if samples are received by 9 am.
- Fasting Required
- No
- Method
- Chemiluminescent Microparticle Immunoassay
Sample Collection
Provide a brief clinical history, including symptoms, medical conditions, and medications. No specific fasting is required, but inform the lab about any vitamin K supplements or anticoagulant use.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw a blood sample from a vein in your arm using standard venipuncture technique.
Report Delivery
Apply pressure to the puncture site with a bandage to minimize bruising. Resume normal activities unless advised otherwise.
Timeline: Reports are typically available the same day if samples are received by 9 am.
Patient Instructions
About This Test
Who Should Get This Test
To aid in the early detection, diagnosis, and monitoring of hepatocellular carcinoma (liver cancer), especially in high-risk populations, by measuring serum levels of DCP/PIVKA II.
How to Prepare
- Provide brief clinical history with sample
- Collect 2 mL blood in an SST tube
- Ship sample refrigerated or frozen
- Ensure proper labeling and documentation
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is a valuable biomarker for hepatocellular carcinoma, particularly useful in high-risk patients with chronic liver disease, aiding in early detection and monitoring."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume (less than 0.5 mL)
- Improperly stored or hemolyzed sample
- Missing clinical history or identification
Understanding Your Results
Normal range; no significant elevation detected
Status: Normal
Range: <40 mAU/mL
Borderline elevation; may require further investigation or monitoring
Status: Borderline
Range: 40-100 mAU/mL
Significantly elevated; suggestive of hepatocellular carcinoma or advanced liver disease; immediate clinical correlation needed
Status: High
Range: >100 mAU/mL
If you have symptoms of liver cancer (e.g., jaundice, abdominal pain, weight loss), a family history of liver cancer, chronic liver disease, or if your test results are abnormal or borderline, consult an oncologist or hepatologist promptly.
Limitations
- ⚠Not a standalone diagnostic test; must be used with imaging and clinical evaluation
- ⚠Elevated levels can occur in non-cancerous conditions like hepatitis or cirrhosis
- ⚠Sensitivity may vary in early-stage cancer
- ⚠Results should be interpreted by a qualified healthcare professional
Risks & Considerations
- ●Minor bruising or soreness at the blood draw site
- ●Rare risk of infection or fainting
- ●No significant risks associated with the test itself
Interfering Factors
- ●Vitamin K antagonist therapy (e.g., warfarin)
- ●Vitamin K deficiency
- ●Severe liver dysfunction affecting coagulation
- ●Recent use of certain antibiotics that alter gut flora
Compare With Similar Tests
| Test | Des-Gamma Carboxy Prothrombin (DCP)/PIVKA II Serum Test | Alpha-Fetoprotein (AFP) Test | Liver Function Tests (LFTs) | Hepatitis B/C Testing | CT/MRI Liver Scan | Liver Biopsy |
|---|---|---|---|---|---|---|
| Comparison | Des-Gamma Carboxy Prothrombin (DCP)/PIVKA II Serum Test |
Frequently Asked Questions
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