DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test
Short Name: DLG3 MRX90 NGS Test
Also known as: DLG3 NGS Test, MRX90 Genetic Test, SAP102 gene sequencing, X-linked intellectual disability type 90 test
DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in The report is delivered online, by email or WhatsApp in approximately 3 to 4 weeks after the laboratory receives the sample.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect disease-causing sequence variants in the DLG3 gene in individuals suspected to have X-linked mental retardation type 90. Establishing a molecular diagnosis can help confirm the clinical suspicion, define the recurrence risk for the family, and guide management and surveillance.
- Test Code
- 4285
- ICD Code
- F79
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- The report is delivered online, by email or WhatsApp in approximately 3 to 4 weeks after the laboratory receives the sample.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger sequencing for variant confirmation
Sample Collection
No fasting required. A genetic counselling session is recommended to draw a pedigree chart of affected family members before the test.
Method: Blood collection by venepuncture or FTA card spotting
Laboratory Analysis
A blood sample is collected by venepuncture, or a few drops of blood are placed on an FTA card, depending on the ordered method.
Report Delivery
No special precautions are needed. The sample should be transported to the laboratory at room temperature.
Timeline: The report is delivered online, by email or WhatsApp in approximately 3 to 4 weeks after the laboratory receives the sample.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect disease-causing sequence variants in the DLG3 gene in individuals suspected to have X-linked mental retardation type 90. Establishing a molecular diagnosis can help confirm the clinical suspicion, define the recurrence risk for the family, and guide management and surveillance.
How to Prepare
- No fasting or special preparation is needed
- Blood sample should be collected in an EDTA vacutainer or spotted on an FTA card as provided
- The sample should be labelled with the patient's name, date of birth and collection time
- The sample should be sent to the laboratory at ambient temperature
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"A targeted DLG3 NGS test is particularly useful in families with an X-linked pattern of intellectual disability. A positive result provides a clear molecular diagnosis and allows accurate genetic counselling of at-risk relatives."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed or clotted blood sample
- Incorrectly labelled sample
- Broken container or leaked sample
- Sample received after prolonged transit without appropriate transport medium
Understanding Your Results
Pathogenic variant detected
Confirms DLG3-related X-linked mental retardation type 90 in a symptomatic individual or identifies carrier status in a female after counselling.
Likely pathogenic variant detected
Likely causative and may be considered consistent with the diagnosis in the appropriate clinical context.
No pathogenic variant detected
No clinically reportable DLG3 mutation was found; a genetic cause in another gene cannot be excluded.
Variant of uncertain significance (VUS)
A DNA change was found, but its effect on health is not yet known; further studies are needed.
You should consult your referring doctor or a clinical geneticist to discuss the test result, especially if it is positive, if a VUS is found, or if the result is negative but clinical suspicion remains strong.
Limitations
- ⚠This test is limited to variants in the DLG3 gene and will not detect mutations in other genes
- ⚠NGS may not detect large deletions, duplications, repeat expansions or methylation changes
- ⚠A variant of uncertain significance (VUS) may require additional family segregation studies
- ⚠A negative result does not exclude a genetic or non-genetic cause of intellectual disability
Risks & Considerations
- ●Minor pain or bruising at the needle site
- ●Lightheadedness or dizziness during blood collection
- ●Very small risk of infection at the puncture site
Interfering Factors
- ●Recent allogeneic bone marrow transplant can confound genetic testing results
- ●Sample contamination or DNA degradation can cause analysis failure
- ●Mosaic variants may be present below the detection limit of NGS
Compare With Similar Tests
| Test | DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test | Chromosomal Microarray (CMA) | X-Linked Intellectual Disability Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the DLG3 gene mental retardation type 90 NGS genetic test in India?
What does the DLG3 NGS genetic test detect?
Who should get this test?
What is X-linked mental retardation type 90?
What type of sample is needed?
Is fasting required for this genetic test?
How long does the report take?
Can this test detect all genetic causes of intellectual disability?
What does a negative DLG3 result mean?
Is genetic counselling included with the test?
Will insurance cover the cost of this test?
What should I do after I receive the report?
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