DNM1 Gene Early infantile epileptic encephalopathy type 31 NGS Genetic Test
Short Name: DNM1 EIEE31 NGS Test
Also known as: DNM1 Gene Mutation Testing, EIEE31 Genetic Test, DNM1-Related Epileptic Encephalopathy NGS Panel
DNM1 Gene Early infantile epileptic encephalopathy type 31 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in The reporting time for the DNM1 Gene EIEE31 NGS Genetic Test is typically 3 to 4 weeks from the date the sample is received at the laboratory. The report will be sent via email/WhatsApp and can also be downloaded from the patient portal.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To detect pathogenic mutations in the DNM1 gene associated with Early Infantile Epileptic Encephalopathy Type 31 (EIEE31). This test helps confirm a clinical diagnosis, guide therapeutic decisions, and provide accurate recurrence-risk counseling for families.
- Test Code
- 4027
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- The reporting time for the DNM1 Gene EIEE31 NGS Genetic Test is typically 3 to 4 weeks from the date the sample is received at the laboratory. The report will be sent via email/WhatsApp and can also be downloaded from the patient portal.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting or preparation is required. A detailed clinical history and pedigree chart are essential before genetic testing. We recommend a genetic counseling session prior to blood collection to discuss the purpose, scope, and implications of the test.
Method: Peripheral blood draw, dried blood spot on FTA card, or extracted DNA submission
Laboratory Analysis
A small amount of blood (1-3 ml) will be collected from the patient (or as per sample type). For infants, a dried blood spot on FTA card may be used. The procedure is quick and minimally invasive.
Report Delivery
There are no activity restrictions following sample collection. The sample should be transported to the laboratory within the specified stability timeframe.
Timeline: The reporting time for the DNM1 Gene EIEE31 NGS Genetic Test is typically 3 to 4 weeks from the date the sample is received at the laboratory. The report will be sent via email/WhatsApp and can also be downloaded from the patient portal.
Patient Instructions
About This Test
Who Should Get This Test
To detect pathogenic mutations in the DNM1 gene associated with Early Infantile Epileptic Encephalopathy Type 31 (EIEE31). This test helps confirm a clinical diagnosis, guide therapeutic decisions, and provide accurate recurrence-risk counseling for families.
How to Prepare
- Ensure the patient is correctly identified with name and date of birth on the sample label.
- For blood collection, use an EDTA vacutainer and mix gently to avoid clotting.
- If using FTA card, apply one drop of blood onto the card and air dry completely.
- If submitting extracted DNA, ensure it is stored properly and shipped in a DNA stabilization buffer.
- Complete the test requisition form with clinical history, indications, and pedigree details.
- The sample should be shipped to the laboratory at ambient temperature (or refrigerated for blood).
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early diagnosis of genetic epilepsies like EIEE31 allows for targeted management, family counseling, and informed reproductive decisions. I recommend genetic testing for infants presenting with refractory seizures and developmental delay."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Sample without proper labeling or requisition form
- Incorrect anticoagulant (e.g., heparin) for DNA extraction
- Sample exposed to extreme temperatures
- Insufficient DNA quantity or quality
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of DNM1-related Early Infantile Epileptic Encephalopathy Type 31. Medical management and genetic counseling are recommended.
Variant of uncertain significance (VUS) detected
The variant may or may not be disease-causing. Further testing of family members and functional studies may help clarify.
No pathogenic variant detected
No DNM1 mutation was identified. Other genetic causes of EIEE should be considered. Whole exome sequencing or a multi-gene epilepsy panel may be recommended.
If your child has early-onset seizures, developmental delay, or features suggestive of an epileptic encephalopathy, or if you have a family history of EIEE31, consult a pediatric neurologist or geneticist. Early genetic testing can significantly improve clinical management and family planning.
Limitations
- ⚠This test does not detect large exonic deletions or duplications, deep intronic variants, or structural chromosome rearrangements.
- ⚠Variants of uncertain clinical significance may be reported and may require segregation analysis.
- ⚠Not designed to detect mitochondrial mutations or repeat expansions.
- ⚠A negative result does not completely rule out EIEE31 caused by variants in other genes or non-coding regulatory regions.
Risks & Considerations
- ●Minimal risk of bruising, bleeding, or infection at the blood collection site
- ●Faintness or dizziness during blood draw (rare)
- ●Psychological implications of receiving an unexpected genetic result
Interfering Factors
- ●Maternal cell contamination in the blood sample
- ●Low DNA yield or degraded DNA
- ●PCR inhibitors in the sample
- ●Incomplete coverage of certain GC-rich regions in the DNM1 gene
- ●Recent blood transfusion (for DNA from blood)
Compare With Similar Tests
| Test | DNM1 Gene Early infantile epileptic encephalopathy type 31 NGS Genetic Test | DNM1 Gene Single-Gene NGS Test | Early Infantile Epileptic Encephalopathy Multi-Gene Panel | Whole Exome Sequencing (WES) |
|---|---|---|---|---|
| Comparison | DNM1 Gene Early infantile epileptic encephalopathy type 31 NGS Genetic Test |
Frequently Asked Questions
What is DNM1 Gene Early Infantile Epileptic Encephalopathy Type 31 (EIEE31)?
What is the cost of the DNM1 gene NGS genetic test?
How is the DNM1 gene NGS test performed?
Does the test require fasting?
How long will the test reports take?
Which sample types are accepted for this test?
Who is a candidate for this genetic test?
What does a positive result mean?
What does a negative result mean?
Is home sample collection available for this test?
Are there any risks associated with the test?
Can this test detect all types of mutations in the DNM1 gene?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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