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F12 Gene Factor XII deficiency NGS Genetic Test

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F12 Gene Factor XII deficiency NGS Genetic Test

Short Name: Factor XII Deficiency NGS Test

Also known as: Hageman Factor Deficiency, Factor XII Deficiency

F12 Gene Factor XII deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose Factor XII deficiency by identifying mutations in the F12 gene using next-generation sequencing technology, aiding in clinical decision-making and genetic counseling.

Test Code
2589
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Inform the healthcare provider about any medications, medical history, or family history of bleeding disorders.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm using a needle. For FTA card collection, a drop of blood is applied to the card.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball to stop bleeding. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:No fasting required. Provide detailed clinical history and a pedigree chart of family members affected with bleeding disorders during genetic counseling.
2
During the Test:Sample collection typically takes 10-15 minutes. The procedure is minimally invasive with low risk.
3
After the Test:Results will be available in 3-4 weeks. Follow up with your healthcare provider to discuss results and next steps.

About This Test

Who Should Get This Test

To diagnose Factor XII deficiency by identifying mutations in the F12 gene using next-generation sequencing technology, aiding in clinical decision-making and genetic counseling.

How to Prepare

  • Ensure proper patient identification and labeling of samples
  • Use sterile collection equipment to avoid contamination
  • For blood samples, collect in EDTA tubes; for FTA cards, follow specific instructions
  • Transport samples at ambient room temperature as specified

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This genetic test is essential for identifying hereditary bleeding disorders and can guide personalized treatment plans, especially in cases with family history or unexplained symptoms."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples: stable for up to 48 hours at room temperature
Extracted DNA: stable for longer periods if stored at appropriate temperatures
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the F12 gene. A positive result confirms Factor XII deficiency, while a negative result suggests no detectable mutations, but clinical correlation is advised.
📊

Positive for pathogenic variant

Confirms diagnosis of Factor XII deficiency. Genetic counseling and personalized treatment planning are recommended to manage bleeding risks.

📊

Negative for pathogenic variant

No mutations detected in the F12 gene. Clinical evaluation should continue if symptoms persist, as other factors may be involved.

📊

Variant of uncertain significance (VUS)

Further testing, family studies, or functional assays may be required to determine clinical significance.

⚠️ When to Consult a Doctor:

Consult a doctor if you have a family history of bleeding disorders, experience unexplained bleeding episodes, or have symptoms of thrombosis such as swelling, pain, or shortness of breath.

Limitations

  • ⚠May not detect all types of genetic mutations, such as large deletions or intronic variants
  • ⚠Results should be interpreted in conjunction with clinical findings and family history
  • ⚠Genetic counseling is recommended for understanding implications

Risks & Considerations

  • ●Minimal risks from blood draw: bruising, slight pain, or rare infection at the puncture site
  • ●Fainting or dizziness in some individuals

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Recent blood transfusion may affect results

Frequently Asked Questions

What is the F12 Gene Factor XII Deficiency NGS Genetic Test?
This test uses next-generation sequencing to analyze the F12 gene for mutations that cause Factor XII deficiency, a rare inherited bleeding disorder.
Why is this test recommended?
It is recommended for individuals with a family history of bleeding disorders, unexplained bleeding symptoms, or to confirm diagnosis after abnormal clotting tests.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to detect mutations in the F12 gene.
What is the cost of the test?
The cost is INR 20000, which includes home sample collection in many cities across India.
Is home sample collection available?
Yes, free home sample collection is available for online bookings in numerous cities, including Mumbai, Delhi, Bangalore, and others.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What do the results mean?
A positive result indicates a mutation in the F12 gene, confirming Factor XII deficiency. A negative result means no mutations were detected, but clinical correlation is advised.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising or infection, which are rare.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, but genetic counseling is recommended for pediatric cases.
Is genetic counseling provided?
Yes, a genetic counseling session is recommended before the test to draw a family pedigree and discuss implications.
What should I do if the test is positive?
Consult a healthcare provider for personalized management, which may include avoiding certain medications, precautions during surgery, or monitoring for thrombosis.
How accurate is the NGS genetic test?
NGS technology offers high accuracy and specificity for detecting mutations in the F12 gene, making it a reliable diagnostic tool.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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