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F2 Gene Factor II deficiency NGS Genetic Test

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F2 Gene Factor II deficiency NGS Genetic Test

Short Name: Factor II Deficiency NGS Test

Also known as: Prothrombin Deficiency Test, F2 Gene Mutation Test, Factor II Genetic Analysis

F2 Gene Factor II deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the F2 gene and associated coagulation genes using NGS technology for accurate diagnosis of Factor II deficiency, enabling tailored clinical management and genetic counseling.

Test Code
1973
Price
₹20,000
Sample Type
Blood, Extracted DNA, or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Inform the healthcare provider about any medications, supplements, or recent medical procedures. Ensure genetic counseling is scheduled prior to testing.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard venipuncture procedure for blood collection; alternatively, a drop of blood on an FTA card may be used.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities unless otherwise advised.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss indications, procedure, and implications. Provide clinical history and family pedigree.
2
During the Test:Blood sample collection via venipuncture or FTA card; minimal discomfort.
3
After the Test:Sample processed in lab; results available in 3-4 weeks. Follow-up counseling recommended.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the F2 gene and associated coagulation genes using NGS technology for accurate diagnosis of Factor II deficiency, enabling tailored clinical management and genetic counseling.

How to Prepare

  • No fasting required unless specified by physician
  • Bring identification and test order forms
  • Ensure proper labeling of samples

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"NGS genetic testing for Factor II deficiency is essential for confirming diagnosis, guiding treatment, and assessing family risk, particularly in cases with bleeding symptoms or thrombosis history."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood sample stable at room temperature for 24 hours
Extracted DNA stable for extended periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrect sample type or insufficient volume
  • Unlabeled or mismatched samples

Understanding Your Results

Results indicate the presence or absence of mutations in the F2 gene associated with Factor II deficiency. Positive findings confirm genetic diagnosis, while negative results suggest no known pathogenic variants, though clinical correlation is essential.
📊

Pathogenic variant detected

Confirms diagnosis of Factor II deficiency; recommend genetic counseling and management

📊

Variant of uncertain significance

Further clinical evaluation and family studies may be needed

📊

No pathogenic variants

Unlikely genetic cause, but symptoms may require additional testing

⚠️ When to Consult a Doctor:

Consult a doctor if you experience persistent bleeding symptoms, have a family history of clotting disorders, or before undergoing surgical procedures to assess bleeding risk.

Limitations

  • ⚠May not detect all possible genetic variants or copy number variations
  • ⚠Requires interpretation by a genetic specialist
  • ⚠Results do not replace clinical evaluation or coagulation function tests

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, soreness, or rare infection
  • ●Psychological impact of genetic results requiring counseling

Interfering Factors

  • ●Sample degradation or contamination
  • ●Inadequate sample volume or quality
  • ●Previous blood transfusions affecting DNA analysis

Compare With Similar Tests

TestF2 Gene Factor II deficiency NGS Genetic TestProthrombin Time (PT) TestFactor II Activity AssaySanger Sequencing
ComparisonF2 Gene Factor II deficiency NGS Genetic Test

Frequently Asked Questions

What is Factor II deficiency?
Factor II deficiency, also known as prothrombin deficiency, is a rare genetic disorder that impairs blood clotting due to mutations in the F2 gene.
How is Factor II deficiency inherited?
It is typically inherited in an autosomal recessive pattern, meaning both parents must carry a mutated gene for the child to develop the condition.
What are the common symptoms of Factor II deficiency?
Symptoms may include easy bruising, prolonged bleeding from cuts, nosebleeds, heavy menstrual bleeding, or bleeding after surgery or dental procedures.
How does the NGS genetic test work?
Next-generation sequencing analyzes the F2 gene and related coagulation genes to identify mutations that cause Factor II deficiency, providing detailed genetic information.
What is the cost of the F2 gene NGS test in India?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available across many cities.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Who should consider this genetic test?
Individuals with a family history of Factor II deficiency, symptoms of abnormal bleeding, or unexplained thrombosis should consider this test.
What does a positive result mean?
A positive result confirms genetic mutations in the F2 gene, indicating Factor II deficiency, and should be interpreted with genetic counseling.
Can this test be done during pregnancy?
Yes, it can be performed during pregnancy for diagnostic or carrier testing, but genetic counseling is advised to discuss implications.
Are there any risks associated with the test?
The test involves a standard blood draw with minimal risks such as bruising or infection. Genetic results may have emotional impacts, so counseling is recommended.
How should I prepare for the test?
No special preparation is needed, but inform your doctor about medications and ensure a genetic counseling session is scheduled before testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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