Factor II Mutation Screening (F2 - G20210A) Test
Short Name: Factor II Mutation Screening
Also known as: F2-G20210A Mutation Screening, Prothrombin Mutation Test, Factor II Gene Test
Factor II Mutation Screening (F2 - G20210A) Test test available at DNA Labs India for ₹6,000. Uses End Point PCR, Restriction Fragment Length Polymorphism (RFLP) on Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of Factor II Mutation Screening is to detect the F2-G20210A mutation to assess an individual's genetic predisposition to venous thromboembolism, aiding in diagnosis, risk stratification, and management of clotting disorders.
- Test Code
- 2999
- Price
- ₹6,000
- Sample Type
- Peripheral blood
- Result Time
- 3-4 days
- Fasting Required
- No
- Method
- End Point PCR, Restriction Fragment Length Polymorphism (RFLP)
Sample Collection
No specific preparation is required. Ensure a doctor's prescription is available if needed for insurance or legal purposes.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw a small blood sample from a vein in your arm using a sterile needle and EDTA vacutainer.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless advised otherwise.
Timeline: 3-4 days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of Factor II Mutation Screening is to detect the F2-G20210A mutation to assess an individual's genetic predisposition to venous thromboembolism, aiding in diagnosis, risk stratification, and management of clotting disorders.
How to Prepare
- Bring a valid doctor's prescription if applicable.
- Wear loose clothing to allow easy access to the arm.
- Inform the phlebotomist of any bleeding disorders or medications.
- Stay hydrated before the test to facilitate blood draw.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for individuals with a personal or family history of unexplained blood clots, recurrent pregnancy loss, or before high-risk surgeries to guide preventive care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample hemolyzed or clotted
- Insufficient sample volume
- Incorrect container or labeling
- Sample older than stability period
Understanding Your Results
Normal (No mutation detected)
No F2-G20210A mutation found. Standard clotting risk applies, but other factors should be considered.
Heterozygous (One copy of mutation)
Carries one copy of the mutation, increasing clotting risk moderately. Lifestyle modifications and monitoring may be recommended.
Homozygous (Two copies of mutation)
Carries two copies of the mutation, significantly elevating clotting risk. Medical intervention, such as anticoagulant therapy, is often advised.
Consult a doctor if you have a positive result, experience symptoms like swelling, pain, or shortness of breath, or have a family history of blood clots. Discuss preventive measures and treatment options.
Limitations
- ⚠This test only detects the F2-G20210A mutation and not other genetic variants associated with thrombophilia.
- ⚠A negative result does not completely rule out genetic risk for blood clots, as other factors may be involved.
- ⚠Results should be interpreted in conjunction with clinical history and other laboratory tests.
- ⚠The test may not be informative for individuals with mosaicism or rare genetic variations.
Risks & Considerations
- ●Minor bruising or pain at the puncture site
- ●Rare risk of infection or excessive bleeding
- ●Fainting or dizziness in sensitive individuals
Interfering Factors
- ●Sample contamination during collection or processing
- ●Degraded DNA due to improper storage or handling
- ●Recent blood transfusions may affect DNA analysis
- ●Technical errors in PCR amplification
Frequently Asked Questions
What is Factor II Mutation Screening?
Why is this test recommended?
How is the test performed?
What do the results mean?
Is fasting required for this test?
How long does it take to get results?
What are the risks of the test?
Can this test be done at home?
Is the test covered by insurance?
What should I do if the test is positive?
How accurate is the Factor II Mutation Screening test?
Where can I get this test done?
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