FAS Gene Autoimmune lymphoproliferative syndrome type 1A NGS Genetic Test
Short Name: ALPS Type 1A NGS Test
Also known as: ALPS Type 1A Genetic Test, FAS Mutation Analysis, Autoimmune Lymphoproliferative Syndrome Test
FAS Gene Autoimmune lymphoproliferative syndrome type 1A NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm a diagnosis of Autoimmune Lymphoproliferative Syndrome Type 1A by identifying mutations in the FAS gene. It aids in differential diagnosis, genetic counseling, and management planning for patients with suspected ALPS.
- Test Code
- 2371
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No specific preparation required. Provide clinical history and family pedigree during genetic counseling session.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist or using an FTA card for home collection. Ensure proper handling to avoid contamination.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store sample at ambient room temperature as per instructions provided.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm a diagnosis of Autoimmune Lymphoproliferative Syndrome Type 1A by identifying mutations in the FAS gene. It aids in differential diagnosis, genetic counseling, and management planning for patients with suspected ALPS.
How to Prepare
- Ensure proper identification of the patient and labeling of samples.
- Use aseptic technique for blood draw to prevent infection.
- For FTA card, apply one drop of blood and let it dry completely before packaging.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for ALPS type 1A is crucial for early diagnosis and management, especially in families with a history of autoimmune disorders or unexplained lymphoproliferation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Insufficient sample volume
- Incorrect labeling or mismatched patient information
- Contaminated or improperly stored sample
Understanding Your Results
Pathogenic variant identified, confirming ALPS type 1A. Clinical management and genetic counseling recommended.
No pathogenic variant detected; consider other genetic or clinical causes if symptoms persist.
Further testing, family studies, or clinical evaluation may be required for clarification.
Consult a geneticist or immunologist if test results are positive or uncertain, or if symptoms persist despite negative results. Early intervention can improve outcomes.
Limitations
- ⚠This test only analyzes the FAS gene and may not detect mutations in other genes associated with ALPS.
- ⚠Variants of uncertain significance (VUS) may be identified, requiring further investigation.
- ⚠Does not assess for somatic mutations in non-germline tissues.
Risks & Considerations
- ●Minimal risk associated with blood draw, such as bruising, soreness, or infection.
- ●Genetic testing may have psychological implications; genetic counseling is recommended to address concerns.
Interfering Factors
- ●Sample contamination
- ●Degraded DNA
- ●Incorrect sample type or collection method
Compare With Similar Tests
| Test | FAS Gene Autoimmune lymphoproliferative syndrome type 1A NGS Genetic Test | Flow Cytometry for ALPS | Sanger Sequencing for FAS Gene | Clinical Evaluation Only |
|---|---|---|---|---|
| Comparison | FAS Gene Autoimmune lymphoproliferative syndrome type 1A NGS Genetic Test | Detects biomarkers like double-negative T cells, but does not provide genetic confirmation for specific mutations. | Sanger sequencing is targeted and may miss some variants; NGS offers comprehensive analysis of the entire gene. | Clinical assessment alone may not distinguish ALPS from other lymphoproliferative disorders; genetic testing is definitive. |
Frequently Asked Questions
What is ALPS type 1A?
How is the FAS gene test performed?
What are the symptoms of ALPS type 1A?
How much does the test cost?
Is home sample collection available?
How long does it take to get results?
What if the test result is positive?
Can this test be done for children?
Is genetic counseling required?
What is the difference between ALPS type 1A and other types?
How accurate is the NGS test?
Are there any risks to genetic testing?
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