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DNA Labs India

FIG4 Gene Amyotrophic Lateral Sclerosis Type 11 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

FIG4 Gene Amyotrophic Lateral Sclerosis Type 11 NGS Genetic Test

Short Name: FIG4 Gene ALS11 NGS

Also known as: FIG4 Gene Mutation Analysis, ALS11 Genetic Test

FIG4 Gene Amyotrophic Lateral Sclerosis Type 11 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered in 3 to 4 weeks after the sample is received by the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAdults (20-50 years)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect pathogenic variants in the FIG4 gene associated with Amyotrophic Lateral Sclerosis Type 11. It aids in confirming a clinical diagnosis, assessing prognosis, and providing familial risk information.

Test Code
3876
ICD Code
G12.2
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are delivered in 3 to 4 weeks after the sample is received by the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history and pedigree chart required. A genetic counseling session is recommended before testing.

Method: Venipuncture or FTA card spot

Step 2

Laboratory Analysis

Blood sample is collected using sterile procedure; no fasting required.

Step 3

Report Delivery

No special precautions needed. You can resume daily activities.

Timeline: Reports are delivered in 3 to 4 weeks after the sample is received by the laboratory.

Patient Instructions

1
Before the Test:No special preparation is required. Carry all relevant clinical documents and a prescription from your neurologist or genetic counsellor.
2
During the Test:A small blood sample is drawn. For FTA card collection, a drop of blood is placed on a card and allowed to dry.
3
After the Test:You can leave immediately after sample collection. There are no restrictions on daily activities.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect pathogenic variants in the FIG4 gene associated with Amyotrophic Lateral Sclerosis Type 11. It aids in confirming a clinical diagnosis, assessing prognosis, and providing familial risk information.

How to Prepare

  • No fasting is required.
  • Please carry your identity proof and prescription.
  • If you are on medications, the doctor may advise to continue.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"ALS is a complex neurological condition; genetic counseling for families is essential. This test helps in identifying the genetic cause."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or FTA card spot

Sample Stability

Room temperature: 2-4 hours for blood
Refrigerated: 48-72 hours
FTA card: Stable for months at room temperature
Sample Rejection Criteria:
  • Hemolyzed blood sample
  • Incorrectly labeled sample
  • Insufficient quantity

Understanding Your Results

The results of this NGS genetic test are interpreted in the context of your clinical history and family pedigree. A positive result indicates the presence of a pathogenic variant in the FIG4 gene associated with ALS type 11.
Positive: Pathogenic variant detected – confirms a genetic diagnosis of ALS type 11. Family members should be offered predictive testing with genetic counseling.
Negative: No pathogenic variant in FIG4 gene found – does not rule out ALS if clinical symptoms are strongly suggestive; other genetic causes may be considered.
Variant of Uncertain Significance (VUS): A variant was identified but clinical significance is unknown. Additional family testing or segregation analysis may be needed.
⚠️ When to Consult a Doctor:

If you have symptoms of ALS or have a family member affected with ALS, speak with a neurologist or medical geneticist to discuss genetic testing.

Limitations

  • ⚠This test does not detect large deletions/duplications or intronic variants beyond splice sites.
  • ⚠A negative result does not exclude the possibility of ALS due to mutations in other genes.
  • ⚠Variants of uncertain significance may be reported; family studies may be required.

Risks & Considerations

  • ●Minimal risk of bleeding or bruising at the puncture site
  • ●Rare chance of infection, as with any blood draw

Interfering Factors

  • ●Low DNA quality or quantity
  • ●Sample mix-up or contamination
  • ●Presence of homologous pseudogenes

Compare With Similar Tests

TestFIG4 Gene Amyotrophic Lateral Sclerosis Type 11 NGS Genetic TestSOD1 Gene ALS NGS TestC9orf72 Gene ALS NGS Test
ComparisonFIG4 Gene Amyotrophic Lateral Sclerosis Type 11 NGS Genetic Test

Frequently Asked Questions

What is the FIG4 gene?
The FIG4 gene provides instructions for making an enzyme called phosphatidylinositol 3,5-bisphosphate 5-phosphatase, which is important for the proper formation and function of lysosomes and endosomes. Mutations in this gene can cause ALS type 11.
What is amyotrophic lateral sclerosis type 11?
ALS type 11 is a rare inherited form of ALS caused by mutations in the FIG4 gene. It is characterized by progressive muscle weakness, spasticity, and muscle wasting, typically beginning in adulthood.
Who should undergo this test?
Individuals with symptoms suggestive of ALS and a family history of the disease, as well as those with an identified FIG4 mutation in their family, are candidates for this test.
How is the test performed?
The test is performed using a blood sample, extracted DNA, or a drop of blood on an FTA card. Next Generation Sequencing (NGS) is used to analyze the FIG4 gene for mutations.
What does a positive result mean?
A positive result means a pathogenic variant in the FIG4 gene was detected, confirming the genetic diagnosis of ALS type 11. It also has implications for family members.
What does a negative result mean?
A negative result means no pathogenic variant was detected in the FIG4 gene. However, this does not rule out ALS because mutations in other genes may be responsible.
How long does it take to get results?
The turnaround time is 3 to 4 weeks.
Is fasting required for this test?
No, fasting is not required. Blood samples can be taken at any time.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available in many cities.
Can symptoms of ALS type 11 be treated?
There is currently no cure, but early diagnosis can help manage symptoms, provide supportive care, and allow for genetic counseling of family members.
Will my insurance cover this test?
This test is generally not covered by government insurance schemes; however, some private health insurance plans may provide partial coverage. Please check with your insurer.
How can I book this test?
You can book online on our website, or contact our call center for assistance. Home sample collection is available across major cities in India.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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