FISH for X and Y Test
Short Name: FISH X/Y
Also known as: FISH for Sex Chromosomes, X and Y Chromosome FISH, Sex Chromosome Aneuploidy FISH
FISH for X and Y Test test available at DNA Labs India for ₹6,000. Uses Fluorescence In Situ Hybridization (FISH) on Peripheral Blood samples. Results in Results are typically available within 1 week after the sample is received by the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the FISH for X and Y test is to identify abnormalities in the number or structure of the X and Y chromosomes. These abnormalities can lead to a range of clinical conditions, including developmental delays, intellectual disability, infertility, and recurrent miscarriages. Early and accurate diagnosis through FISH testing enables timely medical intervention, appropriate genetic counseling, and informed reproductive planning. The test is also used in prenatal settings to detect fetal sex chromosome abnormalities when indicated by ultrasound findings or maternal serum screening.
- Test Code
- 6278
- CPT Code
- 88271
- ICD Code
- Z31.5
- Price
- ₹6,000
- Sample Type
- Peripheral Blood
- Result Time
- Results are typically available within 1 week after the sample is received by the laboratory.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. Inform your doctor about any medications you are taking, especially anticoagulants or chemotherapy drugs.
Method: Venipuncture
Laboratory Analysis
A blood sample is drawn from a vein in your arm. The procedure is quick and causes minimal discomfort.
Report Delivery
You can resume normal activities immediately. There are no restrictions after the test.
Timeline: Results are typically available within 1 week after the sample is received by the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the FISH for X and Y test is to identify abnormalities in the number or structure of the X and Y chromosomes. These abnormalities can lead to a range of clinical conditions, including developmental delays, intellectual disability, infertility, and recurrent miscarriages. Early and accurate diagnosis through FISH testing enables timely medical intervention, appropriate genetic counseling, and informed reproductive planning. The test is also used in prenatal settings to detect fetal sex chromosome abnormalities when indicated by ultrasound findings or maternal serum screening.
How to Prepare
- No fasting required
- Sample must be collected in an EDTA vacutainer
- Sample should be transported to the laboratory at room temperature within 48 hours
- Do not refrigerate or freeze the sample
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"FISH for X and Y is a rapid and reliable method to detect sex chromosome aneuploidies, which is crucial for early diagnosis and management of conditions like Turner syndrome and Klinefelter syndrome."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Sample received after 48 hours of collection
- Incorrect container (e.g., heparin tube)
- Label mismatch or missing patient information
Understanding Your Results
46,XX
Normal female karyotype
46,XY
Normal male karyotype
45,X
Turner syndrome
47,XXY
Klinefelter syndrome
47,XXX
Triple X syndrome
47,XYY
XYY syndrome
Mosaic pattern (e.g., 45,X/46,XX)
Mosaic Turner syndrome or other mosaicism
If you have received abnormal FISH results, or if you have symptoms suggestive of a sex chromosome abnormality, it is important to consult with a genetic counselor or a specialist in clinical genetics for a comprehensive evaluation and management plan.
Limitations
- ⚠FISH only detects specific abnormalities targeted by the probes; it does not detect all chromosomal abnormalities
- ⚠Low-level mosaicism may not be detected
- ⚠Results should be confirmed by conventional karyotyping or chromosomal microarray if clinically indicated
Risks & Considerations
- ●Minimal risk of bleeding or bruising at the puncture site
- ●Rare risk of infection
- ●Fainting or dizziness during blood draw
Interfering Factors
- ●Maternal cell contamination in prenatal samples
- ●Poor sample quality or insufficient cells
- ●Recent blood transfusion (may affect results)
- ●Bone marrow transplant (may affect results)
Compare With Similar Tests
| Test | FISH for X and Y | ||
|---|---|---|---|
| Comparison | FISH for X and Y |
Frequently Asked Questions
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