FISH - Prenatal Screening Panel Chromosomes 13, 18, 21, X & Y Test
Short Name: FISH Prenatal Panel
Also known as: FISH Prenatal Screening Panel, FISH for Chromosomes 13, 18, 21, X, Y
FISH - Prenatal Screening Panel Chromosomes 13, 18, 21, X & Y Test test available at DNA Labs India for ₹12,051. Uses Fluorescence In Situ Hybridization (FISH) on Amniotic fluid samples. Results in Report available within 4 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
To be used as a prenatal screen, in conjunction with full chromosome analysis, to detect aneuploidy such as Trisomy 21, 13, 18, Monosomy X, etc.
- Test Code
- 602
- Price
- ₹12,051
- Sample Type
- Amniotic fluid
- Result Time
- Report available within 4 days after sample receipt.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
Sample must be taken after 15 weeks of gestation. Duly filled Prenatal Genetic Testing Consent Form (Form 18) and Chromosome & FISH Analysis Requisition Form (Form 17) are mandatory.
Method: Amniocentesis
Laboratory Analysis
Amniocentesis procedure performed by a healthcare professional under ultrasound guidance to collect amniotic fluid sample.
Report Delivery
Monitor for any complications such as cramping or leakage. Follow healthcare provider instructions for post-procedure care.
Timeline: Report available within 4 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To be used as a prenatal screen, in conjunction with full chromosome analysis, to detect aneuploidy such as Trisomy 21, 13, 18, Monosomy X, etc.
How to Prepare
- Collect sample after 15 weeks gestation
- Use a sterile screw capped container for amniotic fluid
- Ship at 18-22°C, do not freeze
- Ensure consent and requisition forms are completed and accompany the sample
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This test is crucial for early detection of chromosomal abnormalities in pregnancy, aiding in informed decision-making for expectant parents."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected before 15 weeks gestation
- Inadequate sample volume (less than 7 mL)
- Improper container or storage conditions
- Missing consent or requisition forms
Understanding Your Results
Normal
No aneuploidy detected for chromosomes 13, 18, 21, X, Y. Fetus likely has normal chromosome count for these regions.
Abnormal - Trisomy 21
Three copies of chromosome 21 detected, indicating Down syndrome. Consult genetic counselor for further evaluation.
Abnormal - Trisomy 18
Three copies of chromosome 18 detected, indicating Edwards syndrome. Seek medical advice for management options.
Abnormal - Trisomy 13
Three copies of chromosome 13 detected, indicating Patau syndrome. Discuss implications with healthcare provider.
Abnormal - Sex chromosome aneuploidy
Abnormalities in X or Y chromosomes, such as Monosomy X (Turner syndrome) or XXY (Klinefelter syndrome). Genetic counseling recommended.
Consult a doctor or genetic counselor if results are abnormal, if there is a family history of genetic disorders, or if you have concerns about your pregnancy or test outcomes.
Limitations
- ⚠Screening test, not diagnostic for all chromosomal abnormalities
- ⚠Limited to detection of aneuploidy for specific chromosomes (13, 18, 21, X, Y)
- ⚠May not detect structural chromosomal rearrangements or mosaicism
- ⚠Requires confirmatory testing such as karyotyping for definitive diagnosis
Risks & Considerations
- ●Risk of miscarriage (small percentage)
- ●Infection at the collection site
- ●Premature labor or amniotic fluid leakage
- ●Discomfort or cramping post-procedure
Interfering Factors
- ●Sample contamination or degradation
- ●Incorrect gestational age for sample collection
- ●Technical errors in FISH hybridization
- ●Presence of maternal cell contamination
Compare With Similar Tests
| Test | FISH - Prenatal Screening Panel Chromosomes 13, 18, 21, X & Y Test | ||||
|---|---|---|---|---|---|
| Comparison | FISH - Prenatal Screening Panel Chromosomes 13, 18, 21, X & Y Test | NIPT analyzes cell-free fetal DNA from maternal blood and is less invasive, but FISH provides rapid results for specific chromosomes. | FISH is often performed on amniotic fluid samples, but full karyotyping may be needed for comprehensive analysis. | CVS is performed earlier in pregnancy but carries higher risk; FISH can be applied to CVS samples as well. | Karyotyping provides a full chromosome analysis but takes longer; FISH offers quicker screening for specific aneuploidies. |
Frequently Asked Questions
What is the FISH Prenatal Screening Panel?
When is this test recommended during pregnancy?
How is the sample collected for this test?
What chromosomal abnormalities can this test detect?
Is the FISH test safe for the mother and fetus?
What is the cost of the FISH Prenatal Screening Panel at DNA Labs India?
How long does it take to get the test results?
What do normal test results mean?
What should I do if the test results are abnormal?
Can I get home sample collection for this test?
Is this test covered by insurance schemes like PMJAY or CGHS?
Are there any fasting requirements before the test?
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