FLNA Gene Heterotopia, periventricular, ED variant NGS Genetic Test
Short Name: FLNA Gene NGS Test
Also known as: FLNA Gene NGS Test, Periventricular Heterotopia Genetic Test, BPNH Gene Test, FLNA-Related Disorder Sequencing
FLNA Gene Heterotopia, periventricular, ED variant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from receipt of sample at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of this FLNA gene NGS test is to detect disease-causing pathogenic variants in FLNA in individuals with suspected periventricular heterotopia or FLNA-related neurological disorder. It supports a confirmed genetic diagnosis, defines reproductive risk, and assists clinicians in personalised management of seizures and developmental issues.
- Test Code
- 4119
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from receipt of sample at the laboratory.
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
No special preparation is required. Fasting is not needed. A pre-test genetic counselling session must be completed; please bring relevant clinical records, prior imaging reports, and any previous genetic test results.
Method: Venipuncture / FTA card spot
Laboratory Analysis
A trained phlebotomist will collect a venous blood sample into an EDTA tube. For FTA card collection, a single drop of blood is spotted onto the card and air-dried.
Report Delivery
You can resume regular activities immediately. The sample will be transported to the laboratory for NGS analysis.
Timeline: 3 to 4 weeks from receipt of sample at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this FLNA gene NGS test is to detect disease-causing pathogenic variants in FLNA in individuals with suspected periventricular heterotopia or FLNA-related neurological disorder. It supports a confirmed genetic diagnosis, defines reproductive risk, and assists clinicians in personalised management of seizures and developmental issues.
How to Prepare
- Fasting is not required.
- Complete the genetic counselling session before sample collection.
- Inform the lab about current medications and any previous genetic tests.
- For FTA card, allow the blood spot to dry completely and avoid contamination.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"When periventricular nodular heterotopia is suspected on imaging, FLNA gene analysis is essential. A confirmed molecular diagnosis enables tailored epilepsy management, developmental support, and accurate recurrence-risk counselling for the family."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Frozen whole blood causing hemolysis
- Severely hemolyzed or clotted sample
- Improperly labeled sample
- Sample without counselling or requisition form
Understanding Your Results
No disease-causing mutation was identified in FLNA using this targeted NGS test.
The finding is consistent with FLNA-related periventricular heterotopia and confirms the molecular diagnosis.
Additional family testing and further studies may help clarify the clinical significance of this variant.
The benign variant does not explain the clinical presentation.
If the test identifies a pathogenic variant, consult a clinical geneticist and neurologist for management. If symptoms such as seizures, developmental regression, or neurological deficits appear, seek medical help without delay.
Limitations
- ⚠Targeted NGS of FLNA may not detect large structural rearrangements, deep intronic variants, or repeat expansions.
- ⚠Low-level somatic mosaicism may not be detected.
- ⚠Variants of uncertain significance may require familial segregation studies.
- ⚠A negative result does not exclude all genetic causes; broader testing such as a gene panel or whole exome sequencing may be needed if clinical suspicion remains high.
Risks & Considerations
- ●Mild pain, bruising, or dizziness at the blood collection site
- ●Very small risk of infection
- ●No radiation exposure or fasting-related risk
Interfering Factors
- ●Low DNA quality or quantity
- ●Hemolyzed or clotted blood sample
- ●Maternal cell contamination in prenatal or umbilical cord samples
- ●Pseudogene-related sequence homology
- ●Large deletions or duplications not detected by standard targeted NGS
Compare With Similar Tests
| Test | FLNA Gene Heterotopia, periventricular, ED variant NGS Genetic Test | FLNA Targeted NGS | Epilepsy / Seizure NGS Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | FLNA Gene Heterotopia, periventricular, ED variant NGS Genetic Test |
Frequently Asked Questions
What is FLNA gene heterotopia?
What is the cost of FLNA gene heterotopia NGS genetic test?
What sample is needed for this test?
Is home sample collection available?
How soon will I get the report?
Can this test detect all mutations in the FLNA gene?
Why is a genetic counselling session required before the test?
Why are raw data files like FASTQ and VCF important?
Does this test require fasting?
Who should undergo this FLNA gene test?
Can a negative result rule out FLNA-related disease?
Is this test covered by health insurance?
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