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FLNB Gene Atelosteogenesis type 3 NGS Genetic Test

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FLNB Gene Atelosteogenesis type 3 NGS Genetic Test

Short Name: FLNB AO3 NGS Test

Also known as: AO3, Atelosteogenesis Type 3

FLNB Gene Atelosteogenesis type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the FLNB Gene Atelosteogenesis Type 3 NGS Genetic Test is to confirm the diagnosis of Atelosteogenesis Type 3 by identifying pathogenic mutations in the FLNB gene, enabling accurate medical management and genetic counselling for affected individuals and families.

Test Code
2355
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history review and genetic counselling session to draw a pedigree chart of family members.

Method: Blood Draw or FTA Card

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or use of FTA card for DNA preservation.

Step 3

Report Delivery

Sample is labeled, transported under ambient conditions, and sent to the laboratory for NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counselling and assessment of clinical history.
2
During the Test:Blood sample collection for DNA extraction and NGS sequencing.
3
After the Test:Results are analyzed by geneticists and reported via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

The purpose of the FLNB Gene Atelosteogenesis Type 3 NGS Genetic Test is to confirm the diagnosis of Atelosteogenesis Type 3 by identifying pathogenic mutations in the FLNB gene, enabling accurate medical management and genetic counselling for affected individuals and families.

How to Prepare

  • Provide detailed clinical history of the patient
  • Undergo genetic counselling before sample collection
  • Collect blood sample or DNA extract using sterile techniques

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood Draw or FTA Card
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed sample
  • Improper labeling or storage

Understanding Your Results

Results from the FLNB Gene Atelosteogenesis Type 3 NGS Genetic Test indicate the presence or absence of mutations in the FLNB gene. Interpretation should be done by a qualified geneticist in conjunction with clinical findings.
📊

Pathogenic variant detected

Confirms diagnosis of Atelosteogenesis Type 3; genetic counselling recommended.

📊

No pathogenic variant detected

AO3 unlikely due to FLNB mutations; consider other genetic disorders.

📊

Variant of uncertain significance

Further clinical correlation and family testing advised.

⚠️ When to Consult a Doctor:

Consult a doctor if symptoms of AO3 are present, such as skeletal abnormalities or breathing issues, or if there is a family history of genetic bone disorders.

Limitations

  • ⚠Detects only known mutations in the FLNB gene
  • ⚠May not identify all genetic variants or mutations in other genes
  • ⚠Requires genetic counselling for result interpretation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Potential psychological impact of genetic results

Interfering Factors

  • ●Sample degradation
  • ●Contamination during collection or processing
  • ●Insufficient DNA quantity

Frequently Asked Questions

What is Atelosteogenesis Type 3 (AO3)?
AO3 is a rare genetic disorder affecting bone development, characterized by short limbs, small chest, and curved spine, caused by FLNB gene mutations.
What causes Atelosteogenesis Type 3?
AO3 is caused by mutations in the FLNB gene, which encodes filamin B, a protein crucial for bone structure.
What is the FLNB gene?
The FLNB gene provides instructions for making filamin B, a protein that helps shape and support bones and other tissues.
How is the FLNB Gene NGS Genetic Test performed?
The test uses next-generation sequencing to analyze DNA from blood samples for mutations in the FLNB gene.
What is the cost of the FLNB Gene Atelosteogenesis Type 3 NGS Genetic Test?
The test costs INR 20,000 in India, including home sample collection.
What is the turnaround time for test results?
Results are typically available within 3 to 4 weeks.
Is home sample collection available for this test?
Yes, free home sample collection is offered for online bookings across India.
How accurate is the NGS Genetic Test for AO3?
The test is highly accurate for detecting known mutations in the FLNB gene, but genetic counselling is recommended for interpretation.
Can the test detect all mutations in the FLNB gene?
The test targets known pathogenic mutations, but may not detect all variants or mutations in other genes.
What should I do if the test result is positive?
Consult a geneticist for medical management and genetic counselling to understand implications and treatment options.
Is genetic counselling recommended before the test?
Yes, genetic counselling is advised to discuss test implications, family history, and potential outcomes.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, with potential emotional impact from results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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