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WISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic Test

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WISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic Test

Short Name: PPAC Genetic Test

Also known as: Progressive Pseudorheumatoid Arthropathy of Childhood, PPAC

WISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC) by detecting mutations in the WISP3 gene using NGS technology, aiding in clinical management and treatment decisions.

Test Code
2354
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Blood draw or FTA Card spotting

Step 2

Laboratory Analysis

A small blood sample or saliva sample will be collected by a trained professional.

Step 3

Report Delivery

Sample will be transported to the lab under appropriate conditions for analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended before testing.
2
During the Test:Sample collection is non-invasive with minimal discomfort.
3
After the Test:Results are available online; follow-up with a healthcare provider is advised.

About This Test

Who Should Get This Test

To diagnose Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC) by detecting mutations in the WISP3 gene using NGS technology, aiding in clinical management and treatment decisions.

How to Prepare

  • Fast for 4-6 hours if required, but generally not necessary
  • Ensure proper labeling of the sample
  • Avoid hemolysis by handling blood carefully

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"As a genetic counselor, I recommend WISP3 gene testing for children with unexplained joint symptoms to confirm PPAC and guide management."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeStandard volume
ContainerVacutainer or FTA Card
Collection MethodBlood draw or FTA Card spotting

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods at -20°C
Sample Rejection Criteria:
  • Insufficient sample volume
  • Contaminated or hemolyzed sample
  • Improper labeling or documentation

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the WISP3 gene. Clinical correlation is essential for diagnosis.
Positive result: Pathogenic variant detected, confirming PPAC diagnosis
Negative result: No pathogenic variant detected, but clinical symptoms may warrant further testing
Variant of uncertain significance (VUS): Requires follow-up and family studies
⚠️ When to Consult a Doctor:

Consult a doctor if test results are positive or if symptoms persist despite negative results for further evaluation and management.

Limitations

  • ⚠May not detect all possible mutations in the WISP3 gene
  • ⚠Interpretation requires correlation with clinical findings and family history
  • ⚠Cannot rule out other genetic disorders with overlapping symptoms

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample degradation
  • ●Contamination during collection or transport

Compare With Similar Tests

TestWISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic TestX-ray ImagingJuvenile Idiopathic Arthritis Panel
ComparisonWISP3 Gene Arthropathy, progressive pseudorheumatoid, of childhood NGS Genetic Test

Frequently Asked Questions

What is WISP3 Gene Arthropathy?
It is a rare genetic disorder causing progressive joint and bone problems in children, also known as Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC).
What causes PPAC?
Mutations in the WISP3 gene, which is involved in joint and bone development.
What are the symptoms of PPAC?
Joint pain, stiffness, swelling, limited mobility, short stature, bone deformities, and scoliosis, typically starting in childhood.
How is PPAC diagnosed?
Through clinical evaluation, imaging tests, and genetic testing like NGS of the WISP3 gene.
What is the cost of the WISP3 genetic test?
The test costs INR 20000 at DNA Labs India.
Is home sample collection available?
Yes, free home collection is available across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks.
What sample is required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card.
Is genetic testing accurate for PPAC?
Yes, NGS provides high accuracy in detecting WISP3 gene mutations.
Does insurance cover this test?
Some insurance plans may cover it; check with your provider for specifics.
What should I do if the test is positive?
Consult a healthcare provider for management options, including physical therapy and orthopedic care.
Are there any risks associated with the test?
Risks are minimal, mainly from blood draw, such as bruising or infection.
What is the inheritance pattern of PPAC?
PPAC is inherited in an autosomal recessive pattern, meaning both parents must carry a mutation in the WISP3 gene for a child to be affected.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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