FLRT1 Gene SPG68, FLRT1 related NGS Genetic Test
Short Name: FLRT1 Gene SPG68 Test
Also known as: FLRT1 Mutation Analysis, SPG68 Genetic Test, Hereditary Spastic Paraplegia Type 68 Test, FLRT1 NGS Sequencing Test, Fibronectin Leucine-Rich Transmembrane Protein 1 Gene Test
FLRT1 Gene SPG68, FLRT1 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are delivered via the DNA Labs India online portal, email, and WhatsApp. Urgent processing may be available upon request at additional cost.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the FLRT1 Gene SPG68 NGS Genetic Test is to confirm or rule out a molecular diagnosis of Hereditary Spastic Paraplegia Type 68 (SPG68) in individuals exhibiting clinical features of progressive lower limb spasticity and weakness. This test enables precise identification of pathogenic or likely pathogenic variants in the FLRT1 gene, facilitating accurate diagnosis, differential diagnosis from other forms of hereditary spastic paraplegia (SPG), informed genetic counselling for affected families, carrier screening for at-risk family members, and guidance for clinical management and potential therapeutic strategies.
- Test Code
- 1829
- CPT Code
- 81479
- ICD Code
- G11.4
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One Drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are delivered via the DNA Labs India online portal, email, and WhatsApp. Urgent processing may be available upon request at additional cost.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A genetic counselling session is recommended before sample collection. The counsellor will draw a pedigree chart of family members affected with SPG68 or related neurological disorders. Provide complete clinical history of the patient including symptom onset, progression, and family history. No fasting is required. Inform the laboratory about any recent blood transfusions.
Method: Venipuncture or Finger-prick (FTA Card)
Laboratory Analysis
A trained phlebotomist will collect 3-5 mL of venous blood in an EDTA (lavender top) vacutainer tube. Alternatively, one drop of blood can be spotted on an FTA card. The sample is collected under sterile conditions and labeled with the patient's details. Home sample collection is available at no additional charge for online bookings.
Report Delivery
The blood sample is transported to the laboratory under ambient room temperature conditions. DNA is extracted from the sample and prepared for next-generation sequencing. Results are typically available within 3 to 4 weeks. The clinical report, along with raw data files (FASTQ and VCF), will be shared via the online portal, email, or WhatsApp.
Timeline: Results are typically available within 3 to 4 weeks from the date of sample receipt at the laboratory. Reports are delivered via the DNA Labs India online portal, email, and WhatsApp. Urgent processing may be available upon request at additional cost.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the FLRT1 Gene SPG68 NGS Genetic Test is to confirm or rule out a molecular diagnosis of Hereditary Spastic Paraplegia Type 68 (SPG68) in individuals exhibiting clinical features of progressive lower limb spasticity and weakness. This test enables precise identification of pathogenic or likely pathogenic variants in the FLRT1 gene, facilitating accurate diagnosis, differential diagnosis from other forms of hereditary spastic paraplegia (SPG), informed genetic counselling for affected families, carrier screening for at-risk family members, and guidance for clinical management and potential therapeutic strategies.
How to Prepare
- Collect 3-5 mL of venous blood in an EDTA (lavender top) vacutainer under aseptic conditions
- Alternatively, spot one drop of blood on an FTA card and allow it to dry completely
- Label the sample clearly with patient name, date of birth, sample date, and unique ID
- Transport the sample at ambient room temperature; do not freeze
- Ensure the sample reaches the laboratory within 48 hours of collection
- Avoid hemolysis by using appropriate needle gauge and gentle mixing after collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Hereditary Spastic Paraplegia Type 68 caused by FLRT1 mutations is a rare but clinically significant cause of progressive lower limb spasticity. Accurate molecular diagnosis through NGS-based genetic testing is essential to differentiate SPG68 from other forms of hereditary spastic paraplegia and to guide appropriate clinical management. I recommend this test for any patient presenting with progressive spastic paraparesis of unknown etiology, especially when there is a positive family history suggestive of autosomal recessive inheritance. Early genetic diagnosis enables timely genetic counselling, physiotherapy planning, and screening of at-risk family members."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume (less than 2 mL whole blood)
- Improperly labeled or unlabeled sample
- Sample collected in incorrect tube type (non-EDTA)
- Sample older than stability period at time of receipt
- Severely degraded DNA with insufficient quality metrics
Understanding Your Results
Pathogenic or Likely Pathogenic Variant Detected
Confirms molecular diagnosis of SPG68 (Hereditary Spastic Paraplegia Type 68). Genetic counselling is recommended for the patient and family members. Carrier testing for parents and at-risk relatives should be considered.
No Pathogenic Variant Detected
SPG68 is unlikely but not definitively excluded. Clinical correlation is essential. Consider expanded hereditary spastic paraplegia gene panel testing or whole exome sequencing if clinical suspicion remains high.
Variant of Uncertain Significance (VUS) Identified
The detected variant cannot be definitively classified as pathogenic or benign at this time. Clinical correlation, segregation analysis in the family, and periodic re-evaluation as new data emerge are recommended.
Benign or Likely Benign Variant Detected
The detected variant is considered a normal genetic variation and is not associated with SPG68. No clinical action is required for this finding.
Consult a neurologist or clinical geneticist if you or your child experience progressive difficulty walking, lower limb stiffness or spasticity, unsteady gait, foot drop, or urinary symptoms suggestive of hereditary spastic paraplegia. Early consultation is particularly important if there is a family history of similar neurological symptoms. If your genetic test result is positive, contains a VUS, or if you need help understanding your report, schedule a genetic counselling session to discuss implications for treatment, family planning, and screening of at-risk relatives.
Limitations
- ⚠This test specifically targets the FLRT1 gene; other genetic causes of hereditary spastic paraplegia will not be detected by this single-gene test
- ⚠Novel or rare variants of uncertain significance (VUS) may be identified that cannot be definitively classified at the time of testing
- ⚠Deep intronic variants, regulatory region mutations, and mitochondrial DNA variants are not reliably detected
- ⚠This test does not detect trinucleotide repeat expansions or balanced chromosomal rearrangements
- ⚠Results must always be interpreted in conjunction with clinical findings and family history by a qualified healthcare professional
Risks & Considerations
- ●Minimal physical risk – minor bruising or discomfort at the venipuncture site
- ●Potential psychological impact of receiving a genetic diagnosis or VUS result
- ●Possible implications for family members who may be carriers or at risk
- ●Emotional stress related to genetic testing outcomes; genetic counselling is recommended before and after testing
Interfering Factors
- ●Degraded or low-quality DNA may affect sequencing accuracy and coverage
- ●Contamination during sample collection or processing may produce erroneous results
- ●Recent blood transfusion (within 30 days) may interfere with DNA analysis
- ●Presence of inhibitors in the sample may reduce PCR amplification efficiency
Compare With Similar Tests
| Test | FLRT1 Gene SPG68, FLRT1 related NGS Genetic Test | FLRT1 Gene SPG68 NGS Genetic Test | Hereditary Spastic Paraplegia (HSP) Gene Panel | Whole Exome Sequencing (WES) |
|---|---|---|---|---|
| Comparison | FLRT1 Gene SPG68, FLRT1 related NGS Genetic Test |
Frequently Asked Questions
What is the FLRT1 Gene SPG68 NGS Genetic Test?
What is SPG68 and how does it affect the body?
What sample is required for this genetic test?
How long does it take to get the results?
What is the cost of the FLRT1 Gene SPG68 NGS Genetic Test?
Is home sample collection available for this test?
What are the symptoms of SPG68 that warrant this test?
How is SPG68 inherited?
What happens if a pathogenic mutation is found in my FLRT1 gene?
Can this test be performed on children?
What files and reports are provided with this test?
Is genetic counselling included with this test?
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