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FOXP2 Gene Speech-language disorder type 1 NGS Genetic Test

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FOXP2 Gene Speech-language disorder type 1 NGS Genetic Test

Short Name: FOXP2 NGS Test

Also known as: FOXP2 Gene Sequencing, Speech-Language Disorder Genetic Test, FOXP2 Mutation Analysis

FOXP2 Gene Speech-language disorder type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Gene SequencingPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the FOXP2 gene that cause speech-language disorder type 1. It aids in confirming a clinical diagnosis, providing prognostic information, and enabling genetic counseling for affected families. Early molecular diagnosis can guide therapeutic interventions and educational planning.

Test Code
5936
CPT Code
81407
ICD Code
F80.9
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. However, a genetic counseling session is recommended prior to testing to discuss the purpose, risks, and benefits. Please bring any relevant medical records and family history information.

Method: Venipuncture or Finger-prick

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm, or a finger-prick blood spot may be collected on an FTA card. The procedure is quick and minimally invasive.

Step 3

Report Delivery

You may resume normal activities immediately. The sample will be sent to our laboratory for analysis. Results will be available in 3-4 weeks.

Timeline: Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Before the test, you will have a genetic counseling session to discuss the purpose, process, and potential outcomes. No fasting is required.
2
During the Test:A blood sample is collected by a trained phlebotomist. The procedure takes about 5 minutes.
3
After the Test:You can go home immediately. The sample is sent to the lab. You will be notified when results are ready.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the FOXP2 gene that cause speech-language disorder type 1. It aids in confirming a clinical diagnosis, providing prognostic information, and enabling genetic counseling for affected families. Early molecular diagnosis can guide therapeutic interventions and educational planning.

How to Prepare

  • For blood sample: Use EDTA vacutainer, fill to indicated mark, mix gently.
  • For FTA card: Apply one drop of blood onto the designated circle, allow to air dry.
  • Label the sample with patient name, date of birth, and collection date.
  • Transport at ambient temperature (15-30°C) within 24 hours.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early diagnosis of FOXP2-related speech disorder is crucial for timely speech therapy and family counseling. This NGS test provides definitive molecular confirmation."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume2-3 ml blood or 1 drop on FTA card
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or Finger-prick

Sample Stability

Blood in EDTA
Blood in EDTA
FTA card
Extracted DNA
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Sample received after prolonged transit without proper storage
  • Unlabeled or mislabeled sample
  • Sample from patient who received allogeneic bone marrow transplant (unless specified)

Understanding Your Results

The interpretation of FOXP2 gene sequencing results should be performed by a qualified geneticist. Results are reported as positive, negative, or uncertain.
📊

Positive (pathogenic variant detected)

Confirms diagnosis of FOXP2-related speech-language disorder type 1. Genetic counseling and family testing recommended.

📊

Negative (no pathogenic variant detected)

No mutation found in FOXP2 gene. Other genetic or non-genetic causes should be considered.

📊

Variant of uncertain significance (VUS)

A variant was found but its clinical significance is unknown. Further testing of family members may help clarify.

⚠️ When to Consult a Doctor:

Consult a pediatrician or geneticist if your child shows speech delay, difficulty with articulation, or language comprehension issues. Early referral for genetic testing can aid in diagnosis and management.

Limitations

  • ⚠This test detects mutations only in the FOXP2 gene; other genetic causes of speech disorder are not evaluated.
  • ⚠Large deletions/duplications may not be detected by standard NGS; additional testing may be required.
  • ⚠Variants of uncertain significance (VUS) may be reported; further family studies may be needed.
  • ⚠Regulatory regions and deep intronic variants are not analyzed.
  • ⚠Test does not assess non-genetic causes of speech delay.

Risks & Considerations

  • ●Minimal risk of bruising or infection at the blood draw site
  • ●Psychological impact of receiving genetic results
  • ●Potential for uncertain results (VUS)

Interfering Factors

  • ●Contamination of sample with foreign DNA
  • ●Insufficient DNA quantity or quality
  • ●Presence of maternal cell contamination in prenatal samples
  • ●Recent blood transfusion (for blood samples)

Compare With Similar Tests

TestFOXP2 Gene Speech-language disorder type 1 NGS Genetic TestChromosomal Microarray (CMA)Targeted FOXP2 Sanger SequencingWhole Exome Sequencing (WES)
ComparisonFOXP2 Gene Speech-language disorder type 1 NGS Genetic Test

Frequently Asked Questions

What is the FOXP2 gene?
The FOXP2 gene provides instructions for making a protein that regulates the expression of other genes involved in brain development, particularly areas related to speech and language. Mutations in this gene can lead to speech-language disorder type 1.
What is the cost of the FOXP2 gene NGS test in India?
The test costs INR 20,000 at DNA Labs India. This includes genetic counseling and home sample collection at no extra charge.
What sample is required for this test?
A blood sample (2-3 ml in EDTA tube) or a dried blood spot on an FTA card is acceptable. Extracted DNA can also be submitted.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after the sample reaches the laboratory.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Can this test be done on children?
Yes, this test is specifically designed for pediatric patients with speech and language delays.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the FOXP2 gene, confirming the diagnosis of speech-language disorder type 1. Genetic counseling is recommended.
What if the result is negative?
A negative result means no mutation was found in the FOXP2 gene. Other genetic or environmental causes of speech delay should be explored.
Is home sample collection available?
Yes, we offer free home sample collection across major cities in India for online bookings.
Will my insurance cover this test?
Coverage varies by insurance provider. We recommend checking with your insurer. We also offer a discounted price of INR 20,000.
What is the difference between NGS and Sanger sequencing?
NGS can sequence multiple genes simultaneously and is more comprehensive, while Sanger sequencing is targeted to specific regions. NGS is preferred for detecting all possible variants in FOXP2.
Are there any risks associated with the test?
The test is safe with minimal risks like bruising at the blood draw site. Genetic results may have psychological implications, which is why counseling is included.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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